My general research interest is the pathogenesis of enteric bacterial pathogens. My particular current interest is understanding the pathogenesis of enterohemorrhagic E. coli (EHEC). EHEC produces two toxins, Shiga toxin 1 and Shiga toxin 2. My laboratory has studied the basic structure of these toxins and is continuing to study their role in disease and the effects of immune therapy directed against the toxins may have in ameliorating the disease.