Cummings School of Veterinary Medicine at Tufts University
Xingmin Sun

Research Assistant Professor
Assistant Professor (Second appointment)
Clinical and Translational Science Institute, Tufts University

Campus Phone:
508-887-4252

Fax:
508-839-7911

Education

  • PhD - University of Kiel, Germany - 2002
  • MSc - Nanjing Agricultural University, China - 1994
  • BSc - Nanjing Agricultural University, China - 1991

The roles of host and pathogen factors and the innate immune response in the pathogenesis of Clostridium difficile infection

Author(s):Sun, X. | Hirota, S.A.
Publication year: 2015
Journal / Book title: Molecular Immunology

Beneficial effect of oral tigecycline treatment on clostridium difficile infection in gnotobiotic piglets

Author(s):Kim, H.B. | Zhang, Q. | Sun, X. | Beamer, G. | Wang, Y. | Tziporia, S.
Publication year: 2014
Journal / Book title: Antimicrobial Agents and Chemotherapy

Polyphenolic extract from Rosa rugosa tea inhibits bacterial quorum sensing and biofilm formation

Author(s):Zhang, J. | Rui, X. | Wang, L. | Guan, Y. | Sun, X. | Dong, M.
Publication year: 2014
Journal / Book title: Food Control

Lactobacillus plantarum 70810 from Chinese paocai as a potential source of β-galactosidase for prebiotic galactooligosaccharides synthesis

Author(s):Zhang, H. | Li, W. | Rui, X. | Sun, X. | Dong, M.
Publication year: 2013
Journal / Book title: European Food Research and Technology

A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection

Author(s):Wang, H. | Sun, X. | Zhang, Y. | Li, S. | Chen, K. | Shi, L. | Nie, W. | Kumar, R. | Tzipori, S. | Wang, J. | Savidge, T. | Feng, H.
Publication year: 2012
Journal / Book title: Infection and Immunity

Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models

Author(s):Steele, J. | Chen, K. | Sun, X. | Zhang, Y. | Wang, H. | Tzipori, S. | Feng, H.
Publication year: 2012
Journal / Book title: Journal of Infectious Diseases

Optimization of cryopreservation procedures for porcine endothelial progenitor cells

Author(s):Wu, J. | Lu, Z. | Nie, M. | Zhou, H. | Sun, X. | Xue, X. | Bi, J. | Fang, G.
Publication year: 2012
Journal / Book title: Journal of Bioscience and Bioengineering

Mouse relapse model of Clostridium difficile infection

Author(s):Sun, X. | Wang, H. | Zhang, Y. | Chen, K. | Davis, B. | Feng, H.
Publication year: 2011
Journal / Book title: Infection and Immunity

The Enterotoxicity of Clostridium difficile Toxins

Author(s):Sun, X. | Savidge, T. | Feng, H.
Publication year: 2010
Journal / Book title: Toxins

An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins

Author(s):He, X. | Wang, J. | Steele, J. | Sun, X. | Nie, W. | Tzipori, S. | Feng, H.
Publication year: 2009
Journal / Book title: Journal of Microbiological Methods

Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-α by macrophages

Author(s):Sun, X. | He, X. | Tzipori, S. | Gerhard, R. | Feng, H.
Publication year: 2009
Journal / Book title: Microbial Pathogenesis

Antibody-enhanced, Fc gamma receptor-mediated endocytosis of Clostridium difficile toxin A

Author(s):He, X. | Sun, X. | Wang, J. | Wang, X. | Zhang, Q. | Tzipori, S. | Feng, H.
Publication year: 2009
Journal / Book title: Infection and Immunity

Expression of recombinant Clostridium difficile toxin A and B in Bacillus megaterium

Author(s):Yang, G. | Zhou, B. | Wang, J. | He, X. | Sun, X. | Nie, W. | Tzipori, S. | Feng, H.
Publication year: 2008
Journal / Book title: BMC Microbiology

General Research Interests

My general research interest is microbial pathogenesis, host-pathogen interactions, inflammatory and immune response against pathogen infections, and development of immunotherapies.

My current research focus is on the pathogenesis of Clostridium difficile.  C. difficile infection (CDI) has become a significant public health threat in the past decade. Toxins TcdA and TcdB are two major virulent factors of C. difficile. We are investigating C. difficile toxin-mediated signal transduction, leading to the production of proinflammatory mediators, such as TNF-α. We are also developing preventive and therapeutic approaches targeting C. diffcile toxins and proinflammatory mediators in CDI. We have established several animal models of CDI.

Selected Research Projects

  1. Evaluation of novel therapeutics in animal models of CDI including mice and hamsters.
  2. The innate immune responses to CDI.
  3. The relative roles of C. difficile toxins in animal models.
  4. Signaling pathway of TNF-α production and Clostridium difficile infection (CDI). The major goal is to elucidate the signaling pathway of toxin-mediated TNF-α production and develop a novel therapy against CDI by targeted blocking of TNF-α production.
  5. Development of novel therapeutic agents against C. difficile infection.
  6. Regulation of C. difficile toxin production.

Lab Members

  • Dr. Keshan Zhang
  • Dr. Song Zhao