Cummings School of Veterinary Medicine at Tufts University
Saul Tzipori

Distinguished Professor of Microbiology and Infectious Diseases
Agnes Varis University Chair in Science and Society
Chair, Department of Infectious Disease and Global Health

Infectious Disease, Enteric Infections and Host Response

Campus Phone:
508-839-7955

Fax:
508-839-7977

Education

  • FRCVS - Fellow Royal College of Veterinary Surgeons, London - 1990
  • DSc - University of Melbourne, Australia - 1985
  • Ph.D. - University of Queensland, Australia - 1974
  • DVM - (BVSc) - University of Queensland, Australia - 1970

Systemically administered IgG anti-toxin antibodies protect the colonic mucosa during infection with Clostridium difficilein the piglet model

Author(s):Cohen, O.R. | Steele, J.A. | Zhang, Q. | Schmidt, D.J. | Wang, Y. | Hamel, P.E.S. | Beamer, G. | Xu, B. | Tzipori, S.
Publication year: 2014
Journal / Book title: PLoS ONE

The immune response of two microbial antigens delivered intradermally, sublingually, or the combination thereof

Author(s):Lee, S. | Picking, W.L. | Tzipori, S.
Publication year: 2014
Journal / Book title: Microbes and Infection

Selective evolution of ligands by exponential enrichment to identify rna aptamers against shiga toxins

Author(s):Challa, S. | Tzipori, S. | Sheoran, A.
Publication year: 2014
Journal / Book title: Journal of Nucleic Acids

Interaction of Cryptosporidium parvum with mouse dendritic cells leads to their activation and parasite transportation to mesenteric lymph nodes

Author(s):Perez-Cordon, G. | Yang, G. | Zhou, B. | Nie, W. | Li, S. | Shi, L. | Tzipori, S. | Feng, H.
Publication year: 2014
Journal / Book title: Pathogens and Disease

The immune response of two microbial antigens delivered intradermally, sublingually, or the combination thereof

Author(s):Lee, S. | Picking, W.L. | Tzipori, S.
Publication year: 2014
Journal / Book title: Microbes and Infection

The evolution of respiratory cryptosporidiosis: Evidence for transmission by inhalation

Author(s):Sponseller, J.K. | Griffiths, J.K. | Tzipori, S.
Publication year: 2014
Journal / Book title: Clinical Microbiology Reviews

A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2.

Author(s):Tremblay, J.M. | Mukherjee, J. | Leysath, C.E. | Debatis, M. | Ofori, K. | Baldwin, K. | Boucher, C. | Peters, R. | Beamer, G. | Sheoran, A. | Bedenice, D. | Tzipori, S. | Shoemaker, C.B.
Publication year: 2013
Journal / Book title: Infection and immunity

The roles of toxin A and toxin B in Clostridium difficile infection: Insights from the gnotobiotic piglet model

Author(s):Steele, J. | Parry, N. | Tzipori, S.
Publication year: 2013
Journal / Book title: Gut Microbes

Frequent occurrence of mixed enterocytozoon bieneusi infections in humans

Author(s):Widmer, G. | Dilo, J. | Tumwine, J.K. | Tzipori, S. | Akiyoshi, D.E.
Publication year: 2013
Journal / Book title: Applied and Environmental Microbiology

Evaluation of virulent and live Shigella sonnei vaccine candidates in a gnotobiotic piglet model

Author(s):Jeong, K.-I. | Venkatesan, M.M. | Barnoy, S. | Tzipori, S.
Publication year: 2013
Journal / Book title: Vaccine

MBX-500 Is effective for treatment of clostridium difficile infection in gnotobiotic piglets

Author(s):Steele, J. | Zhang, Q. | Beamer, G. | Butler, M. | Bowlin, T. | Tzipori, S.
Publication year: 2013
Journal / Book title: Antimicrobial Agents and Chemotherapy

Hyperimmune bovine colostrum for treatment of GI infections: A review and update on clostridium difficile

Author(s):Steele, J. | Sponseller, J. | Schmidt, D. | Cohen, O. | Tzipori, S.
Publication year: 2013
Journal / Book title: Human Vaccines and Immunotherapeutics

Proteomic View of Interactions of Shiga Toxin-Producing Escherichia coli with the Intestinal Environment in Gnotobiotic Piglets

Author(s):Pieper, R. | Zhang, Q. | Clark, D.J. | Parmar, P.P. | Alami, H. | Suh, M.-J. | Kuntumalla, S. | Braisted, J.C. | Huang, S.-T. | Tzipori, S.
Publication year: 2013
Journal / Book title: PLoS ONE

A pig model of the human gastrointestinal tract

Author(s):Zhang, Q. | Widmer, G. | Tzipori, S.
Publication year: 2013
Journal / Book title: Gut Microbes

Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic clostridium difficile disease

Author(s):Steele, J. | Mukherjee, J. | Parry, N. | Tzipori, S.
Publication year: 2013
Journal / Book title: Journal of Infectious Diseases

Sheep monoclonal antibodies prevent systemic effects of botulinum neurotoxin A1

Author(s):Mukherjee, J. | McCann, C. | Ofori, K. | Hill, J. | Baldwin, K. | Shoemaker, C.B. | Harrison, P. | Tzipori, S.
Publication year: 2012
Journal / Book title: Toxins

Allele- and Tir-independent functions of intimin in diverse animal infection models

Author(s):Mallick, E.M. | Brady, M.J. | Luperchio, S.A. | Vanguri, V.K. | Magoun, L. | Liu, H. | Sheppard, B.J. | Mukherjee, J. | Donohue-Rolfe, A. | Tzipori, S. | Leong, J.M. | Schauer, D.B.
Publication year: 2012
Journal / Book title: Frontiers in Microbiology

MBX-500, a hybrid antibiotic with in vitro and in vivo efficacy against toxigenic Clostridium difficile

Author(s):Butler, M.M. | Shinabarger, D.L. | Citron, D.M. | Kelly, C.P. | Dvoskin, S. | Wright, G.E. | Feng, H. | Tzipori, S. | Bowlin, T.L.
Publication year: 2012
Journal / Book title: Antimicrobial Agents and Chemotherapy

A chimeric toxin vaccine protects against primary and recurrent Clostridium difficile infection

Author(s):Wang, H. | Sun, X. | Zhang, Y. | Li, S. | Chen, K. | Shi, L. | Nie, W. | Kumar, R. | Tzipori, S. | Wang, J. | Savidge, T. | Feng, H.
Publication year: 2012
Journal / Book title: Infection and Immunity

Bacillus subtilis: a temperature resistant and needle free delivery system of immunogens.

Author(s):Amuguni, H. | Tzipori, S.
Publication year: 2012
Journal / Book title: Human vaccines & immunotherapeutics

General Research Interests

Enteric infections and the host response; this includes viral, bacterial and protozoan pathogens of veterinary and medical importance causing acute or chronic diarrhea in the immunocompetent or the immunodeficient host. In recent years investigations have focused specifically on:
  • The biology, pathogenesis, immunology, epidemiology, diagnosis, treatment, prevention and control of cryptosporidiosis and microsporidiosis in children from developing countries, and in individuals with HIV/AIDS.
  • Mechanisms of disease caused by Shiga-toxin producing E. coli(STEC), and development of therapy against the associated hemolytic uremic syndrome (HUS) - a complicating acute kidney failure in children.
  • Development of botulinum antitoxin therapy and control of intoxication in humans.
  • Development of strategies for identification, characterization and risk assessment of food and waterborne pathogens.
  • Development and preclinical evaluation of temperature-resistant and needle-free human vaccines for developing countries.
  • Clostridium difficile Disease: Investigations on the biology, pathogenesis, and development of therapy and vaccines.
  • Characterization of the human microbiome in the germfree pig model to investigate human gastrointestinal disorders.
  • Global health and RESPOND: a USAID sponsored project under EPT (Emerging Pandemic Threats).

Selected Research Projects

  • Respiratory cryptosporidiosis in Uganda.
  • Immune based therapy against hemolytic uremic syndrome caused by shiga-toxin producing E. coli.
  • Botulinum biology and development of antitoxin therapy.
  • Investigations on the infant and adult human microbiomes in the germfree piglet model.
  • Development and evaluation of Bacillus subtilis as a delivery system of temperature resistant and non-invasive vaccines.
  • Preclinical evaluation of enteric vaccines against shigellosis.
  • Clostridium difficile: studies on; a) vaccine development and methods of administration; b) development and evaluation of  antimicrobial agents; c) development and evaluation of immune-based therapeutics; d) development of animal models to investigate pathogenic mechanisms.
  • Development and use of a thigh mouse model to specifically test drugs against multidrug resistant bacteria.

Research Interests by Area

Infectious Diseases: Prevention and Control
  • Botulism antidotes and anti-toxins
  • Therapy for cryptosporidiosis, Vaccine delivery systems, Monoclonal antibodies to HUS prophylaxis, botulism antidote
Infectious Diseases: Genetics and Genomics
  • Cryptosporidium genome sequencing
Infectious Diseases: Pathogenesis/Host Response
  • Pathogenesis of cryptosporidium parvum, microsporidium, E. Coli O157