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Sangun Lee - DVM, MS, PhD

Sangun Lee
Research Assistant Professor

Campus Phone:


  • PhD –University of Idaho, 2003
  • MS – Seoul National University, South Korea, 1995
  • DVM – Seoul National University, South Korea, 1991
  1. Sangun Lee, Melanie Ginese, Don Girouard, Gillian Beamer, Christopher D. Huston, David W. Griggs, Saul Tzipori (2018) Therapeutic Efficacy of MMV665917 in the acute Pig Model of Cryptosporidium hominis.
  2. Sangun Lee, Gillian Beamer, Saul Tzipori (2018) The Piglet Acute Diarrhea Model for Evaluating Efficacy of Treatment and Control of Cryptosporiosis. Human Vaccine & Immunotherapeutics. DOI:10.1080/21645515.2018.1498436.
  3. Lee, S., M. Ginese, G. Beamer, H. R. Danz, D. J. Girouard, S. P. Chapman-Bonofiglio, M. Lee, M. A. Hulverson, R. Choi, G. R. Whitman, K. K. Ojo, S. L. M. Arnold, W. C. Van Voorhis and S. Tzipori (2018). Therapeutic Efficacy of Bumped Kinase Inhibitor 1369 in the Acute Pig Model of Cryptosporidium hominis. Antimicrob Agents Chemother. DOI: 10.1128/AAC.00147-18
  4. Sangun Lee, Melanie Harwood, Don Girouard, Marvin J. Meyers, Mary A. Campbell, Gillian Beamer, Saul Tzipori (2017) The therapeutic efficacy of azithromycin and nitazoxanide in the acute pig model of Cryptosporidium hominis. PLoS One 12(10): e0185906.
  5. Jordan A. Stinson, Waseem K. Raja, Sangun Lee, Hyeun Bum Kim, Izzuddin Diwan, Stephen Tutunjian, Bruce Panilaitis, Fiorenzo G. Omenetto, Saul Tzipori, and David L. Kaplan (2017) Silk Fibroin Microneedles for Transdermal Vaccine Delivery. ACS Biomaterials Science & Engineering 3: 360-369
  6. Bingling Xu, Waseem K. Raja, Sangun Lee, Weilong Liu, Izzuddin M. Diwan, Bruce J. Panilaitis, David L. Kaplan, and Saul Tzipori (2016) Silk-based microneedle transdermal immunization with EV71 vaccines elicits potent immune responses in mice. Journal of Vaccines & Immunization 4:1-8.
  7. Mary Morada, Sangun Lee, Leslie Gunther-Cummins, Louis M. Weiss, Giovanni Widmer, Saul Tzipori and Nigel Yarletta (2016) Continuous culture of Cryptosporidium parvum using hollow fiber technology. International Journal for Parasitology 46:21-29
  8. Sangun Lee, Wendy Picking, Saul Tzipori (2014) The Immune Response of Two Microbial Antigens Delivered Intradermally, Sublingually, or the Combination Thereof. Microbes and Infection 16:796–803.J. Hellen Amuguni, Sangun Lee, Kathryn O. Kerstein, David W. Brown, Boris R. Belitsky, John E. Herrmann, Gerald T. Keusch, Abraham L. Sonenshein, and Saul Tzipori (2012) Sublingual immunization with engineered Bacillus subtilis strain expressing tetanus toxin fragment C induces systemic and mucosal immune responses in piglets. Microbes and Infection 14:447-56.
  9. Sangun Lee, Yanhai Wang, Sung Ouk Kim, and Jiahuai Han (2011) AMPD3 is involved in anthrax lethal toxin-induced macrophage cell death. Protein & Cell 2:564-72.
  10. J. Hellen Amuguni*, Sangun Lee*, John E. Herrmann, Abraham L. Sonenshein, and Saul Tzipori (2011) Sublingually administered Bacillus subtilis cells expressing tetanus toxin C fragment induce protective systemic and mucosal antibodies against tetanus toxin in mice. Vaccine 29:4778-84.  *contributed equally
  11. Sangun Lee, Boris R. Belitsky, David W. Brown, James P. Brinker, Kathy O. Kerstein, John E. Herrmann, Gerald T. Keusch, Abraham L. Sonenshein , and Saul Tzipori (2010) Efficacy, heat stability and safety of intranasally administered Bacillus subtilis spore or vegetative cell vaccines expressing tetanus toxin fragment C. Vaccine
  12. Sangun Lee, Boris R. Belitsky, James P. Brinker, Kathy O. Kerstein, David W. Brown, Gerald T. Keusch, Saul Tzipori, Abraham L. Sonenshein , John D. Clements , and John E. Herrmann (2010) Development of a Bacillus subtilis-based rotavirus vaccine. Clinical and Vaccine Immunology 17:1647-55.

General Research Interests

  • Vaccine development
  • Host-microbe interaction
  • Microbial pathogenesis

Selected Research Projects

  • Animal model and in vitro culture of Cryptosporidium spp. 
  • Development of a novel, effective vaccine delivery strategy
  • Development of Bacillus subtilis as a delivery vehicle of vaccines and therapeutics
  • Clostridium difficile pathogenesisImmunization strategy for non-living Shigella vaccines
  • Development of Bacillus subtilis vaccine platforms for heat-stable, needle-free vaccines
  • Effective delivery of the therapeutic antibodies using Bacillus subtilis