Sandra Ayres

Sandra Ayres
Assistant Professor
Goat Reproduction, Transgenics, Cloning, Theriogenology
Section of Neuroscience and Reproductive Biology

Campus Phone:



  • DVM with Thesis - Tufts University - 1993
  • MA - Duke University - 1973
  • BS - Duke University - 1971

Board Certification

  • American College of Theriogenologists, 1999

Superovulation in goats during the second follicular wave, with or without exogenous progesterone

Author(s):Ayres, S.L. | Gavin, W. | Memili, E. | Behboodi, E.
Publication year: 2012
Journal / Book title: Small Ruminant Research

Non-viral transfection of goat germline stem cells by nucleofection results in production of transgenic sperm after germ cell transplantation

Author(s):Zeng, W. | Tang, L. | Bondareva, A. | Luo, J. | Megee, S.O. | Modelski, M. | Blash, S. | Melican, D.T. | Destrempes, M.M. | Overton, S.A. | Gavin, W.G. | Ayres, S. | Echelard, Y. | Dobrinski, I.
Publication year: 2012
Journal / Book title: Molecular Reproduction and Development

Surgical management of the goat

Author(s):Cunneen, M. | Ayres, S.
Publication year: 2011
Journal / Book title: Lab Animal

Induction of HIV-1 MPR649-684-specific IgA and IgG antibodies in caprine colostrum using a peptide-based vaccine

Author(s):Dorosko, S.M. | Ayres, S.L. | Connor, R.I.
Publication year: 2008
Journal / Book title: Vaccine

Adeno-associated virus (AAV)-mediated transduction of male germ line stem cells results in transgene transmission after germ cell transplantation

Author(s):Honaramooz, A. | Megee, S. | Zeng, W. | Destrempes, M.M. | Overton, S.A. | Luo, J. | Galantino-Homer, H. | Modelski, M. | Chen, F. | Blash, S. | Melican, D.T. | Gavin, W.G. | Ayres, S. | Yang, F. | Wang, P.J. | Echelard, Y. | Dobrinski, I.
Publication year: 2008
Journal / Book title: FASEB Journal

Reproductive Health Program

Author(s):Ayres, S.L.
Publication year: 2006
Journal / Book title: Current Therapy in Large Animal Theriogenology: Second Edition

Depletion of endogenous germ cells in male pigs and goats in preparation for germ cell transplantation

Author(s):Honaramooz, A. | Behboodi, E. | Hausler, C.L. | Blash, S. | Ayres, S. | Azuma, C. | Echelard, Y. | Dobrinski, I.
Publication year: 2005
Journal / Book title: Journal of Andrology

Health and reproductive profiles of malaria antigen-producing transgenic goats derived by somatic cell nuclear transfer

Author(s):Behboodi, E. | Ayres, S.L. | Memili, E. | O'Coin, M. | Chen, L.H. | Reggio, B.C. | Landry, A.M. | Gavin, W.G. | Meade, H.M. | Godke, R.A. | Echelard, Y.
Publication year: 2005
Journal / Book title: Cloning and Stem Cells

Predicting the onset of parturition in the goat by determining progesterone levels by enzyme immunoassay

Author(s):Singer, L.A. | Kumar, M.S.A. | Gavin, W. | Ayres, S.L.
Publication year: 2004
Journal / Book title: Small Ruminant Research

Regional distribution of gonadotropin-releasing hormone-like, β-endorphin-like, and methionine-enkephalin-like immunoreactivities in the central nervous system of the goat

Author(s):Karuri, A.R. | Ayres, S. | Kumar, M.S.A.
Publication year: 2000
Journal / Book title: Brain Research Bulletin

Production of goats by somatic cell nuclear transfer

Author(s):Baguisi, A. | Behboodi, E. | Melican, D.T. | Pollock, J.S. | Destrempes, M.M. | Cammuso, C. | Williams, J.L. | Nims, S.D. | Porter, C.A. | Midura, P. | Palacios, M.J. | Ayres, S.L. | Denniston, R.S. | Hayes, M.L. | Ziomek, C.A. | Meade, H.M. | Godke, R.A. | Gavin, W.G. | Overström, E.W. | Echelard, Y.
Publication year: 1999
Journal / Book title: Nature Biotechnology

Induction of human tissue plasminogen activator in the mammary gland of transgenic goats

Author(s):Ebert, K.M. | DiTullio, P. | Barry, C.A. | Schindler, J.E. | Ayres, S.L. | Smith, T.E. | Pellerin, L.J. | Meade, H.M. | Denman, J. | Roberts, B.
Publication year: 1994
Journal / Book title: Nature Biotechnology

General Research Interests

  • Caprine Reproduction: Advanced reproductive techniques, particularly in relationship to transgenics and cloning.

Selected Research Projects

  • Production of Cloned Goats
  • Superovulation in Goats without the Use of Exogenous Progesterone
  • Use of a Vital Fluorescent Stain to Detect Apoptosis in Oocytes and Embryos
  • Development of a Short Progesterone Protocol for Superovulation in Goats

Research Interests by Area

Neuroscience and Reproductive Biology
  • Advanced Reproductive Techniques and Population Control

    The regulation and control of reproduction in domestic and wild animals is a critical are of One Health, with outcomes impacting humans, animals and the environment. Optimizing methods and technologies that can improve reproductive outcomes and control population growth requires an in depth knowledge of species-specific reproductive physiology. Currently, advanced reproductive techniques (ART) research within the section includes studies investigating the regulation of the estrous cycle in small ruminants in an effort to better understand the hormonal physiology of superovulation and out of season breeding. Previous studies have applied ART to the production of transgenic and cloned small ruminants. With regard to population control, recent work involves a project aimed at developing novel therapeutics for controlling populations of feral cats and dogs. In addition, two ongoing projects within the section are aimed at assessing and implementing population control of wild horses and white tailed deer. Learn more.

Reproductive Biology and Neuroscience
  • Refinement of oocyte collection in the goat

Major Specialized Equipment

  • Fluorescence microscope
  • Microinjection microscope