Roderick T. Bronson

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Professor
Pathology, Markers of Aging
Pathology

Campus Phone:
617-432-2409

Education

  • DVM - University of California, Davis - 1972
  • BA - University of California, Berkeley - 1964

Board Certification

  • American College of Veterinary Pathology
  1. Romero, R., Sayin, V.I., Davidson, S.M., Bauer, M.R., Singh, S.X., Leboeuf, S.E., Karakousi, T.R., Ellis, D.C., Bhutkar, A., Sánchez-Rivera, F.J., Subbaraj, L., Martinez, B., Bronson, R.T., Prigge, J.R., Schmidt, E.E., Thomas, C.J., Goparaju, C., Davies, A., Dolgalev, I., Heguy, A., Allaj, V., Poirier, J.T., Moreira, A.L., Rudin, C.M., Pass, H.I., Vander Heiden, M.G., Jacks, T., Papagiannakopoulos, T. 2017. Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis. Nature Medicine.
  2. Otto, T., Candido, S.V., Pilarz, M.S., Sicinska, E., Bronson, R.T., Bowden, M., Lachowicz, I.A., Mulry, K., Fassl, A., Han, R.C., Jecrois, E.S., Sicinski, P. 2017. Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit. Proceedings of the National Academy of Sciences of the United States of America.
  3. Wang, Z., Zheng, Q., Zhang, H., Bronson, R.T., Madsen, J.C., Sachs, D.H., Huang, C.A., Wang, Z. 2017. Ontak-like human IL-2 fusion toxin. Journal of Immunological Methods.
  4. Morse, K., Kimizuka, Y., Chan, M.P.K., Shibata, M., Shimaoka, Y., Takeuchi, S., Forbes, B., Nirschl, C., Li, B., Zeng, Y., Bronson, R.T., Katagiri, W., Shigeta, A., Srbulescu, R.F., Chen, H., Tan, R.Y.Y., Tsukada, K., Brauns, T., Gelfand, J., Sluder, A., Locascio, J.J., Poznansky, M.C., Anandasabapathy, N., Kashiwagi, S. 2017. Near-infrared 1064 nm laser modulates migratory dendritic cells to augment the immune response to intradermal influenza vaccine. Journal of Immunology.
  5. Kimizuka, Y., Callahan, J.J., Huang, Z., Morse, K., Katagiri, W., Shigeta, A., Bronson, R., Takeuchi, S., Shimaoka, Y., Chan, M.P.K., Zeng, Y., Li, B., Chen, H., Tan, R.Y.Y., Dwyer, C., Mulley, T., Leblanc, P., Goudie, C., Gelfand, J., Tsukada, K., Brauns, T., Poznansky, M.C., Bean, D., Kashiwagi, S. 2017. Semiconductor diode laser device adjuvanting intradermal vaccine. Vaccine.
  6. Wan, L., Chen, M., Cao, J., Dai, X., Yin, Q., Zhang, J., Song, S.-J., Lu, Y., Liu, J., Inuzuka, H., Katon, J.M., Berry, K., Fung, J., Ng, C., Liu, P., Song, M.S., Xue, L., Bronson, R.T., Kirschner, M.W., Cui, R., Pandolfi, P.P., Wei, W. 2017. The APC/C E3 ligase complex activator fzr1 restricts braf oncogenic function. Cancer Discovery.
  7. Foijer, F., Albacker, L.A., Bakker, B., Spierings, D.C., Yue, Y., Xie, S.Z., Davis, S., Lutum-Jehle, A., Takemoto, D., Hare, B., Furey, B., Bronson, R.T., Lansdorp, P.M., Bradley, A., Sorger, P.K. 2017. Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma. eLife.
  8. Guerriero, J.L., Sotayo, A., Ponichtera, H.E., Castrillon, J.A., Pourzia, A.L., Schad, S., Johnson, S.F., Carrasco, R.D., Lazo, S., Bronson, R.T., Davis, S.P., Lobera, M., Nolan, M.A., Letai, A. 2017. Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages. Nature.
  9. Liu, L., Michowski, W., Inuzuka, H., Shimizu, K., Nihira, N.T., Chick, J.M., Li, N., Geng, Y., Meng, A.Y., Ordureau, A., Kołodziejczyk, A., Ligon, K.L., Bronson, R.T., Polyak, K., Harper, J.W., Gygi, S.P., Wei, W., Sicinski, P. 2017. G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Nature Cell Biology.
  10. Lee, S.-G., Mikhalchenko, A.E., Yim, S.H., Lobanov, A.V., Park, J.-K., Choi, K.-H., Bronson, R.T., Lee, C.-K., Park, T.J., Gladyshev, V.N. 2017. Naked Mole Rat Induced Pluripotent Stem Cells and Their Contribution to Interspecific Chimera. Stem Cell Reports.
  11. Li Chew, C., Lunardi, A., Gulluni, F., Ruan, D.T., Chen, M., Salmena, L., Nishino, M., Papa, A., Ng, C., Fung, J., Clohessy, J.G., Sasaki, J., Sasaki, T., Bronson, R.T., Hirsch, E., Pandolfi, P.P. 2015. In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes. Cancer discovery.
  12. Sanchez-Rivera, F.J., Papagiannakopoulos, T., Romero, R., Tammela, T., Bauer, M.R., Bhutkar, A., Joshi, N.S., Subbaraj, L., Bronson, R.T., Xue, W., Jacks, T. 2014. Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Nature.
  13. Xue, W., Chen, S., Yin, H., Tammela, T., Papagiannakopoulos, T., Joshi, N.S., Cai, W., Yang, G., Bronson, R., Crowley, D.G., Zhang, F., Anderson, D.G., Sharp, P.A., Jacks, T. 2014. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature.
  14. Chow, K.-H., Shin, D.-M., Jenkins, M.H., Miller, E.E., Shih, D.J., Choi, S., Low, B.E., Philip, V., Rybinski, B., Bronson, R.T., Taylor, M.D., Yun, K. 2014. Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity. Cancer Research.
  15. Tchaicha, J.H., Akbay, E.A., Altabef, A., Mikse, O.R., Kikuchi, E., Rhee, K., Liao, R.G., Bronson, R.T., Sholl, L.M., Meyerson, M., Hammerman, P.S., Wong, K.-K. 2014. Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC. Cancer Research.
  16. Xue, W., Dahlman, J.E., Tammela, T., Khan, O.F., Sood, S., Dave, A., Cai, W., Chirino, L.M., Yang, G.R., Bronson, R., Crowley, D.G., Sahay, G., Schroeder, A., Langer, R., Anderson, D.G., Jacks, T. 2014. Small RNA combination therapy for lung cancer. Proceedings of the National Academy of Sciences of the United States of America.
  17. Lu, G., Zhang, Q., Huang, Y., Song, J., Tomaino, R., Ehrenberger, T., Lim, E., Liu, W., Bronson, R.T., Bowden, M., Brock, J., Krop, I.E., Dillon, D.A., Gygi, S.P., Mills, G.B., Richardson, A.L., Signoretti, S., Yaffe, M.B., Kaelin, W.G. 2014. Phosphorylation of ETS1 by src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell.
  18. Wan, L., Hu, G., Wei, Y., Yuan, M., Bronson, R.T., Yang, Q., Siddiqui, J., Pienta, K.J., Kang, Y. 2014. Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Research.
  19. Sinkevicius, K.W., Kriegel, C., Bellaria, K.J., Lee, J., Lau, A.N., Leeman, K.T., Zhou, P., Beede, A.M., Fillmore, C.M., Caswell, D., Barrios, J., Wong, K.-K., Sholl, L.M., Schlaeger, T.M., Bronson, R.T., Chirieac, L.R., Winslow, M.M., Haigis, M.C., Kim, C.F. 2014. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proceedings of the National Academy of Sciences of the United States of America.
  20. Byun, A.J., Hung, K.E., Fleet, J.C., Bronson, R.T., Mason, J.B., Garcia, P.E., Crott, J.W. 2014. Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras. Cancer Letters.

General Research Interests

  • Pathology of mutant mice
  • Pathology of aging
  • Cancer pathobiology

Research Interests by Area

Other Areas of Research
  • Mutant Mouse pathology