Cummings School of Veterinary Medicine at Tufts University
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Professor

Pathology, Markers of Aging
Pathology

Campus Phone:
617-432-2409

Education

  • DVM - University of California, Davis - 1972
  • BA - University of California, Berkeley - 1964

Board Certification

  • American College of Veterinary Pathology

CRISPR-mediated direct mutation of cancer genes in the mouse liver

Author(s):Xue, W. | Chen, S. | Yin, H. | Tammela, T. | Papagiannakopoulos, T. | Joshi, N.S. | Cai, W. | Yang, G. | Bronson, R. | Crowley, D.G. | Zhang, F. | Anderson, D.G. | Sharp, P.A. | Jacks, T.
Publication year: 2014
Journal / Book title: Nature

Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC

Author(s):Tchaicha, J.H. | Akbay, E.A. | Altabef, A. | Mikse, O.R. | Kikuchi, E. | Rhee, K. | Liao, R.G. | Bronson, R.T. | Sholl, L.M. | Meyerson, M. | Hammerman, P.S. | Wong, K.-K.
Publication year: 2014
Journal / Book title: Cancer Research

Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity

Author(s):Chow, K.-H. | Shin, D.-M. | Jenkins, M.H. | Miller, E.E. | Shih, D.J. | Choi, S. | Low, B.E. | Philip, V. | Rybinski, B. | Bronson, R.T. | Taylor, M.D. | Yun, K.
Publication year: 2014
Journal / Book title: Cancer Research

Small RNA combination therapy for lung cancer

Author(s):Xue, W. | Dahlman, J.E. | Tammela, T. | Khan, O.F. | Sood, S. | Dave, A. | Cai, W. | Chirino, L.M. | Yang, G.R. | Bronson, R. | Crowley, D.G. | Sahay, G. | Schroeder, A. | Langer, R. | Anderson, D.G. | Jacks, T.
Publication year: 2014
Journal / Book title: Proceedings of the National Academy of Sciences of the United States of America

Phosphorylation of ETS1 by src family kinases prevents its recognition by the COP1 tumor suppressor

Author(s):Lu, G. | Zhang, Q. | Huang, Y. | Song, J. | Tomaino, R. | Ehrenberger, T. | Lim, E. | Liu, W. | Bronson, R.T. | Bowden, M. | Brock, J. | Krop, I.E. | Dillon, D.A. | Gygi, S.P. | Mills, G.B. | Richardson, A.L. | Signoretti, S. | Yaffe, M.B. | Kaelin, W.G.
Publication year: 2014
Journal / Book title: Cancer Cell

Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis

Author(s):Wan, L. | Hu, G. | Wei, Y. | Yuan, M. | Bronson, R.T. | Yang, Q. | Siddiqui, J. | Pienta, K.J. | Kang, Y.
Publication year: 2014
Journal / Book title: Cancer Research

Histone deacetylase III as a potential therapeutic target for the treatment of lethal sepsis

Author(s):Zhao, T. | Li, Y. | Liu, B. | Bronson, R.T. | Halaweish, I. | Alam, H.B.
Publication year: 2014
Journal / Book title: Journal of Trauma and Acute Care Surgery

Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis

Author(s):Sinkevicius, K.W. | Kriegel, C. | Bellaria, K.J. | Lee, J. | Lau, A.N. | Leeman, K.T. | Zhou, P. | Beede, A.M. | Fillmore, C.M. | Caswell, D. | Barrios, J. | Wong, K.-K. | Sholl, L.M. | Schlaeger, T.M. | Bronson, R.T. | Chirieac, L.R. | Winslow, M.M. | Haigis, M.C. | Kim, C.F.
Publication year: 2014
Journal / Book title: Proceedings of the National Academy of Sciences of the United States of America

Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras

Author(s):Byun, A.J. | Hung, K.E. | Fleet, J.C. | Bronson, R.T. | Mason, J.B. | Garcia, P.E. | Crott, J.W.
Publication year: 2014
Journal / Book title: Cancer Letters

Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer

Author(s):Roper, J. | Sinnamon, M.J. | Coffee, E.M. | Belmont, P. | Keung, L. | Georgeon-Richard, L. | Wang, W.V. | Faber, A.C. | Yun, J. | Yilmaz, T.H. | Bronson, R.T. | Martin, E.S. | Tsichlis, P.N. | Hung, K.E.
Publication year: 2014
Journal / Book title: Cancer Letters

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

Author(s):Papa, A. | Wan, L. | Bonora, M. | Salmena, L. | Song, M.S. | Hobbs, R.M. | Lunardi, A. | Webster, K. | Ng, C. | Newton, R.H. | Knoblauch, N. | Guarnerio, J. | Ito, K. | Turka, L.A. | Beck, A.H. | Pinton, P. | Bronson, R.T. | Wei, W. | Pandolfi, P.P.
Publication year: 2014
Journal / Book title: Cell

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice

Author(s):Akbay, E.A. | Moslehi, J. | Christensen, C.L. | Saha, S. | Tchaicha, J.H. | Ramkissoon, S.H. | Stewart, K.M. | Carretero, J. | Kikuchi, E. | Zhang, H. | Cohoon, T.J. | Murray, S. | Liu, W. | Uno, K. | Fisch, S. | Jones, K. | Gurumurthy, S. | Gliser, C. | Choe, S. | Keenan, M. | Son, J. | Stanley, I. | Losman, J.A. | Padera, R. | Bronson, R.T. | Asara, J.M. | Abdel-Wahab, O. | Amrein, P.C. | Fathi, A.T. | Danial, N.N. | Kimmelman, A.C. | Kung, A.L. | Ligon, K.L. | Yen, K.E. | Kaelin Jr., W.G. | Bardeesy, N. | Wong, K.-K.
Publication year: 2014
Journal / Book title: Genes and Development

A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma

Author(s):Yuan, J. | Kashiwagi, S. | Reeves, P. | Nezivar, J. | Yang, Y. | Arrifin, N.H. | Nguyen, M. | Jean-Mary, G. | Tong, X. | Uppal, P. | Korochkina, S. | Forbes, B. | Chen, T. | Righi, E. | Bronson, R. | Chen, H. | Orsulic, S. | Brauns, T. | Leblanc, P. | Scholler, N. | Dranoff, G. | Gelfand, J. | Poznansky, M.C.
Publication year: 2014
Journal / Book title: Journal of Hematology and Oncology

Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma

Author(s):Jun, H.J. | Bronson, R.T. | Charest, A.
Publication year: 2014
Journal / Book title: Stem Cells

Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4

Author(s):Munera, D. | Ritchie, J.M. | Hatzios, S.K. | Bronson, R. | Fang, G. | Schadt, E.E. | Davis, B.M. | Waldor, M.K.
Publication year: 2014
Journal / Book title: Nature Communications

Rapid dendritic cell activation and resistance to allotolerance induction in anti-CD154-treated mice receiving CD47-deficient donor-specific transfusion

Author(s):Wang, Y. | Wang, H. | Bronson, R. | Fu, Y. | Yang, Y.-G.
Publication year: 2014
Journal / Book title: Cell Transplantation

Selective histone deacetylase-6 inhibition attenuates stress responses and prevents immune organ atrophy in a lethal septic model

Author(s):Zhao, T. | Li, Y. | Bronson, R.T. | Liu, B. | Velmahos, G.C. | Alam, H.B.
Publication year: 2014
Journal / Book title: Surgery (United States)

A mouse Col4a4 mutation causing Alport glomerulosclerosis with abnormal collagen α3α4α5(IV) trimers

Author(s):Korstanje, R. | Caputo, C.R. | Doty, R.A. | Cook, S.A. | Bronson, R.T. | Davisson, M.T. | Miner, J.H.
Publication year: 2014
Journal / Book title: Kidney International

ROS1 signaling regulates epithelial differentiation in the epididymis

Author(s):Jun, H.J. | Roy, J. | Smith, T.B. | Wood, L.B. | Lane, K. | Woolfenden, S. | Punko, D. | Bronson, R.T. | Haigis, K.M. | Breton, S. | Charest, A.
Publication year: 2014
Journal / Book title: Endocrinology

Role of aberrant PI3K pathway activation in gallbladder tumorigenesis

Author(s):Lunardi, A. | Webster, K.A. | Papa, A. | Padmani, B. | Clohessy, J.G. | Bronson, R.T. | Pandolfi, P.P.
Publication year: 2014
Journal / Book title: Oncotarget

General Research Interests

  • Pathology of mutant mice
  • Pathology of aging
  • Cancer pathobiology

Research Interests by Area

Other Areas of Research
  • Mutant Mouse pathology