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Roderick T. Bronson - DVM, BA

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Professor
Pathology, Markers of Aging
Pathology

Campus Phone:
617-432-2409

Education

  • DVM - University of California, Davis - 1972
  • BA - University of California, Berkeley - 1964

Board Certification

  • American College of Veterinary Pathology
  1. Sethi, N.S., Kikuchi, O., Duronio, G.N., Stachler, M.D., McFarland, J.M., Ferrer-Luna, R., Zhang, Y., Bao, C., Bronson, R., Patil, D., Sanchez-Vega, F., Liu, J.-B., Sicinska, E., Lazaro, J.-B., Ligon, K.L., Beroukhim, R., Bass, A.J. 2020. Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model. Nature Genetics.
  2. Ng, S.R., Rideout, W.M., Akama-Garren, E.H., Bhutkar, A., Mercer, K.L., Schenkel, J.M., Bronson, R.T., Jacks, T. 2020. CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer. Proceedings of the National Academy of Sciences of the United States of America.
  3. Prabhakar, S., Cheah, P.S., Zhang, X., Zinter, M., Gianatasio, M., Hudry, E., Bronson, R.T., Kwiatkowski, D.J., Stemmer-Rachamimov, A., Maguire, C.A., Sena-Esteves, M., Tannous, B.A., Breakefield, X.O. 2019. Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1. Molecular Therapy - Methods and Clinical Development.
  4. Gluchowski, N.L., Gabriel, K.R., Chitraju, C., Bronson, R.T., Mejhert, N., Boland, S., Wang, K., Lai, Z.W., Farese, R.V., Walther, T.C. 2019. Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice. Hepatology.
  5. Mukherjee, P., Augur, Z.M., Li, M., Hill, C., Greenwood, B., Domin, M.A., Kondakci, G., Narain, N.R., Kiebish, M.A., Bronson, R.T., Arismendi-Morillo, G., Chinopoulos, C., Seyfried, T.N. 2019. Therapeutic benefit of combining calorie-restricted ketogenic diet and glutamine targeting in late-stage experimental glioblastoma. Communications Biology.
  6. Oser, M.G., Sabet, A.H., Gao, W., Chakraborty, A.A., Schinzel, A.C., Jennings, R.B., Fonseca, R., Bonal, D.M., Booker, M.A., Flaifel, A., Novak, J.S., Christensen, C.L., Zhang, H., Herbert, Z.T., Tolstorukov, M.Y., Buss, E.J., Wong, K.-K., Bronson, R.T., Nguyen, Q.-D., Signoretti, S., Kaelin, W.G. 2019. The KDM5A/RBP2 histone demethylase represses NOTCH signaling to sustain neuroendocrine differentiation and promote small cell lung cancer tumorigenesis. Genes & development.
  7. Wang, B., Li, D., Yao, Y., Heyns, M., Kovalchuk, A., Ilnytskyy, Y., Rodriguez-Juarez, R., Bronson, R.T., Metz, G.A.S., Kovalchuk, O., Kovalchuk, I. 2019. The crucial role of DNA-dependent protein kinase and myelin transcription factor 1-like protein in the miR-141 tumor suppressor network. Cell Cycle.
  8. Mattaini, K.R., Sullivan, M.R., Lau, A.N., Fiske, B.P., Bronson, R.T., Heiden, M.G.V. 2019. Increased PHGDH expression promotes aberrant melanin accumulation. BMC Cancer.
  9. Wu, X., Koh, G.Y., Huang, Y., Crott, J.W., Bronson, R.T., Mason, J.B. 2019. The Combination of Curcumin and Salsalate is Superior to Either Agent Alone in Suppressing Pro-Cancerous Molecular Pathways and Colorectal Tumorigenesis in Obese Mice. Molecular Nutrition and Food Research.
  10. Chen, M., Zhang, J., Berger, A.H., Diolombi, M.S., Ng, C., Fung, J., Bronson, R.T., Castillo-Martin, M., Thin, T.H., Cordon-Cardo, C., Plevin, R., Pandolfi, P.P. 2019. Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis. Journal of Clinical Investigation.
  11. Lesch, B.J., Tothova, Z., Morgan, E.A., Liao, Z., Bronson, R.T., Ebert, B.L., Page, D.C. 2019. Intergenerational epigenetic inheritance of cancer susceptibility in mammals. eLife.
  12. Nelson, D.S., Marano, R.L., Joo, Y., Tian, S.Y., Patel, B., Kaplan, D.H., Shlomchik, M.J., Stevenson, K., Bronson, R.T., Rollins, B.J. 2019. BRAF V600E and Pten deletion in mice produces a histiocytic disorder with features of Langerhans cell histiocytosis. PLoS ONE.
  13. Zoeller, J.J., Vagodny, A., Taneja, K., Tan, B.Y., O'Brien, N., Slamon, D.J., Sampath, D., Leverson, J.D., Bronson, R.T., Dillon, D.A., Brugge, J.S. 2019. Neutralization of Bcl-2/XL enhances the cytotoxicity of T-DM1 in vivo. Molecular Cancer Therapeutics.
  14. Barros-Silva, J.D., Linn, D.E., Steiner, I., Guo, G., Ali, A., Pakula, H., Ashton, G., Peset, I., Brown, M., Clarke, N.W., Bronson, R.T., Yuan, G.-C., Orkin, S.H., Li, Z., Baena, E. 2018. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Reports.
  15. Du, H., Dreier, J.R., Zarei, M., Wu, C.-L., Bronson, R.W., Kwiatkowski, D.J. 2018. A novel mouse model of hemangiopericytoma due to loss of Tsc2. Human molecular genetics.
  16. Ding, L., Kim, H.-J., Wang, Q., Kearns, M., Jiang, T., Ohlson, C.E., Li, B.B., Xie, S., Liu, J.F., Stover, E.H., Howitt, B.E., Bronson, R.T., Lazo, S., Roberts, T.M., Freeman, G.J., Konstantinopoulos, P.A., Matulonis, U.A., Zhao, J.J. 2018. PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer. Cell Reports.
  17. Santana-Codina, N., Roeth, A.A., Zhang, Y., Yang, A., Mashadova, O., Asara, J.M., Wang, X., Bronson, R.T., Lyssiotis, C.A., Ying, H., Kimmelman, A.C. 2018. Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis. Nature Communications.
  18. Dischinger, P.S., Tovar, E.A., Essenburg, C.J., Madaj, Z.B., Gardner, E.E., Callaghan, M.E., Turner, A.N., Challa, A.K., Kempston, T., Eagleson, B., Kesterson, R.A., Bronson, R.T., Bowman, M.J., Graveel, C.R., Steensma, M.R. 2018. NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer. npj Breast Cancer.
  19. Jun, H.J., Appleman, V.A., Wu, H.-J., Rose, C.M., Pineda, J.J., Yeo, A.T., Delcuze, B., Lee, C., Gyuris, A., Zhu, H., Woolfenden, S., Bronisz, A., Nakano, I., Chiocca, E.A., Bronson, R.T., Ligon, K.L., Sarkaria, J.N., Gygi, S.P., Michor, F., Mitchison, T.J., Charest, A. 2018. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nature Communications.
  20. Chang, A.N., Liang, Z., Dai, H.-Q., Chapdelaine-Williams, A.M., Andrews, N., Bronson, R.T., Schwer, B., Alt, F.W. 2018. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature.

General Research Interests

  • Pathology of mutant mice
  • Pathology of aging
  • Cancer pathobiology

Research Interests by Area

Other Areas of Research
  • Mutant Mouse pathology