Roderick T. Bronson

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Professor
Pathology, Markers of Aging
Pathology

Campus Phone:
617-432-2409

Education

  • DVM - University of California, Davis - 1972
  • BA - University of California, Berkeley - 1964

Board Certification

  • American College of Veterinary Pathology
  1. Liu, L., Michowski, W., Inuzuka, H., Shimizu, K., Nihira, N.T., Chick, J.M., Li, N., Geng, Y., Meng, A.Y., Ordureau, A., Kołodziejczyk, A., Ligon, K.L., Bronson, R.T., Polyak, K., Harper, J.W., Gygi, S.P., Wei, W., Sicinski, P. 2017. G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells. Nature Cell Biology.
  2. Sanchez-Rivera, F.J., Papagiannakopoulos, T., Romero, R., Tammela, T., Bauer, M.R., Bhutkar, A., Joshi, N.S., Subbaraj, L., Bronson, R.T., Xue, W., Jacks, T. 2014. Rapid modelling of cooperating genetic events in cancer through somatic genome editing. Nature.
  3. Xue, W., Chen, S., Yin, H., Tammela, T., Papagiannakopoulos, T., Joshi, N.S., Cai, W., Yang, G., Bronson, R., Crowley, D.G., Zhang, F., Anderson, D.G., Sharp, P.A., Jacks, T. 2014. CRISPR-mediated direct mutation of cancer genes in the mouse liver. Nature.
  4. Tchaicha, J.H., Akbay, E.A., Altabef, A., Mikse, O.R., Kikuchi, E., Rhee, K., Liao, R.G., Bronson, R.T., Sholl, L.M., Meyerson, M., Hammerman, P.S., Wong, K.-K. 2014. Kinase domain activation of FGFR2 yields high-grade lung adenocarcinoma sensitive to a pan-FGFR inhibitor in a mouse model of NSCLC. Cancer Research.
  5. Chow, K.-H., Shin, D.-M., Jenkins, M.H., Miller, E.E., Shih, D.J., Choi, S., Low, B.E., Philip, V., Rybinski, B., Bronson, R.T., Taylor, M.D., Yun, K. 2014. Epigenetic states of cells of origin and tumor evolution drive tumor-initiating cell phenotype and tumor heterogeneity. Cancer Research.
  6. Xue, W., Dahlman, J.E., Tammela, T., Khan, O.F., Sood, S., Dave, A., Cai, W., Chirino, L.M., Yang, G.R., Bronson, R., Crowley, D.G., Sahay, G., Schroeder, A., Langer, R., Anderson, D.G., Jacks, T. 2014. Small RNA combination therapy for lung cancer. Proceedings of the National Academy of Sciences of the United States of America.
  7. Lu, G., Zhang, Q., Huang, Y., Song, J., Tomaino, R., Ehrenberger, T., Lim, E., Liu, W., Bronson, R.T., Bowden, M., Brock, J., Krop, I.E., Dillon, D.A., Gygi, S.P., Mills, G.B., Richardson, A.L., Signoretti, S., Yaffe, M.B., Kaelin, W.G. 2014. Phosphorylation of ETS1 by src family kinases prevents its recognition by the COP1 tumor suppressor. Cancer Cell.
  8. Wan, L., Hu, G., Wei, Y., Yuan, M., Bronson, R.T., Yang, Q., Siddiqui, J., Pienta, K.J., Kang, Y. 2014. Genetic ablation of metadherin inhibits autochthonous prostate cancer progression and metastasis. Cancer Research.
  9. Sinkevicius, K.W., Kriegel, C., Bellaria, K.J., Lee, J., Lau, A.N., Leeman, K.T., Zhou, P., Beede, A.M., Fillmore, C.M., Caswell, D., Barrios, J., Wong, K.-K., Sholl, L.M., Schlaeger, T.M., Bronson, R.T., Chirieac, L.R., Winslow, M.M., Haigis, M.C., Kim, C.F. 2014. Neurotrophin receptor TrkB promotes lung adenocarcinoma metastasis. Proceedings of the National Academy of Sciences of the United States of America.
  10. Byun, A.J., Hung, K.E., Fleet, J.C., Bronson, R.T., Mason, J.B., Garcia, P.E., Crott, J.W. 2014. Colon-specific tumorigenesis in mice driven by Cre-mediated inactivation of Apc and activation of mutant Kras. Cancer Letters.
  11. Roper, J., Sinnamon, M.J., Coffee, E.M., Belmont, P., Keung, L., Georgeon-Richard, L., Wang, W.V., Faber, A.C., Yun, J., Yilmaz, T.H., Bronson, R.T., Martin, E.S., Tsichlis, P.N., Hung, K.E. 2014. Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. Cancer Letters.
  12. Papa, A., Wan, L., Bonora, M., Salmena, L., Song, M.S., Hobbs, R.M., Lunardi, A., Webster, K., Ng, C., Newton, R.H., Knoblauch, N., Guarnerio, J., Ito, K., Turka, L.A., Beck, A.H., Pinton, P., Bronson, R.T., Wei, W., Pandolfi, P.P. 2014. Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function. Cell.
  13. Akbay, E.A., Moslehi, J., Christensen, C.L., Saha, S., Tchaicha, J.H., Ramkissoon, S.H., Stewart, K.M., Carretero, J., Kikuchi, E., Zhang, H., Cohoon, T.J., Murray, S., Liu, W., Uno, K., Fisch, S., Jones, K., Gurumurthy, S., Gliser, C., Choe, S., Keenan, M., Son, J., Stanley, I., Losman, J.A., Padera, R., Bronson, R.T., Asara, J.M., Abdel-Wahab, O., Amrein, P.C., Fathi, A.T., Danial, N.N., Kimmelman, A.C., Kung, A.L., Ligon, K.L., Yen, K.E., Kaelin Jr., W.G., Bardeesy, N., Wong, K.-K. 2014. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes and Development.
  14. Yuan, J., Kashiwagi, S., Reeves, P., Nezivar, J., Yang, Y., Arrifin, N.H., Nguyen, M., Jean-Mary, G., Tong, X., Uppal, P., Korochkina, S., Forbes, B., Chen, T., Righi, E., Bronson, R., Chen, H., Orsulic, S., Brauns, T., Leblanc, P., Scholler, N., Dranoff, G., Gelfand, J., Poznansky, M.C. 2014. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma. Journal of Hematology and Oncology.
  15. Jun, H.J., Bronson, R.T., Charest, A. 2014. Inhibition of EGFR induces a c-MET-driven stem cell population in glioblastoma. Stem Cells.
  16. Munera, D., Ritchie, J.M., Hatzios, S.K., Bronson, R., Fang, G., Schadt, E.E., Davis, B.M., Waldor, M.K. 2014. Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4. Nature Communications.
  17. Wang, Y., Wang, H., Bronson, R., Fu, Y., Yang, Y.-G. 2014. Rapid dendritic cell activation and resistance to allotolerance induction in anti-CD154-treated mice receiving CD47-deficient donor-specific transfusion. Cell Transplantation.
  18. Zhao, T., Li, Y., Bronson, R.T., Liu, B., Velmahos, G.C., Alam, H.B. 2014. Selective histone deacetylase-6 inhibition attenuates stress responses and prevents immune organ atrophy in a lethal septic model. Surgery (United States).
  19. Meira, L.B., Calvo, J.A., Shah, D., Klapacz, J., Moroski-Erkul, C.A., Bronson, R.T., Samson, L.D. 2014. Repair of endogenous DNA base lesions modulate lifespan in mice. DNA Repair.
  20. Lunardi, A., Webster, K.A., Papa, A., Padmani, B., Clohessy, J.G., Bronson, R.T., Pandolfi, P.P. 2014. Role of aberrant PI3K pathway activation in gallbladder tumorigenesis. Oncotarget.

General Research Interests

  • Pathology of mutant mice
  • Pathology of aging
  • Cancer pathobiology

Research Interests by Area

Other Areas of Research
  • Mutant Mouse pathology