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Roderick T. Bronson - DVM, BA

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Professor
Pathology, Markers of Aging
Pathology

Campus Phone:
617-432-2409

Education

  • DVM - University of California, Davis - 1972
  • BA - University of California, Berkeley - 1964

Board Certification

  • American College of Veterinary Pathology
  1. Zoeller, J.J., Vagodny, A., Taneja, K., Tan, B.Y., O'Brien, N., Slamon, D.J., Sampath, D., Leverson, J.D., Bronson, R.T., Dillon, D.A., Brugge, J.S. 2019. Neutralization of BCL-2/XL Enhances the Cytotoxicity of T-DM1 In Vivo. Molecular cancer therapeutics.
  2. Lesch, B.J., Tothova, Z., Morgan, E.A., Liao, Z., Bronson, R.T., Ebert, B.L., Page, D.C. 2019. Intergenerational epigenetic inheritance of cancer susceptibility in mammals. eLife.
  3. Wu, X., Koh, G.Y., Huang, Y., Crott, J.W., Bronson, R.T., Mason, J.B. 2019. The Combination of Curcumin and Salsalate is Superior to Either Agent Alone in Suppressing Pro-Cancerous Molecular Pathways and Colorectal Tumorigenesis in Obese Mice. Molecular Nutrition and Food Research.
  4. Chen, M., Zhang, J., Berger, A.H., Diolombi, M.S., Ng, C., Fung, J., Bronson, R.T., Castillo-Martin, M., Thin, T.H., Cordon-Cardo, C., Plevin, R., Pandolfi, P.P. 2019. Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis. Journal of Clinical Investigation.
  5. Barros-Silva, J.D., Linn, D.E., Steiner, I., Guo, G., Ali, A., Pakula, H., Ashton, G., Peset, I., Brown, M., Clarke, N.W., Bronson, R.T., Yuan, G.-C., Orkin, S.H., Li, Z., Baena, E. 2018. Single-Cell Analysis Identifies LY6D as a Marker Linking Castration-Resistant Prostate Luminal Cells to Prostate Progenitors and Cancer. Cell Reports.
  6. Du, H., Dreier, J.R., Zarei, M., Wu, C.-L., Bronson, R.W., Kwiatkowski, D.J. 2018. A novel mouse model of hemangiopericytoma due to loss of Tsc2. Human molecular genetics.
  7. Ding, L., Kim, H.-J., Wang, Q., Kearns, M., Jiang, T., Ohlson, C.E., Li, B.B., Xie, S., Liu, J.F., Stover, E.H., Howitt, B.E., Bronson, R.T., Lazo, S., Roberts, T.M., Freeman, G.J., Konstantinopoulos, P.A., Matulonis, U.A., Zhao, J.J. 2018. PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer. Cell Reports.
  8. Santana-Codina, N., Roeth, A.A., Zhang, Y., Yang, A., Mashadova, O., Asara, J.M., Wang, X., Bronson, R.T., Lyssiotis, C.A., Ying, H., Kimmelman, A.C. 2018. Oncogenic KRAS supports pancreatic cancer through regulation of nucleotide synthesis. Nature Communications.
  9. Dischinger, P.S., Tovar, E.A., Essenburg, C.J., Madaj, Z.B., Gardner, E.E., Callaghan, M.E., Turner, A.N., Challa, A.K., Kempston, T., Eagleson, B., Kesterson, R.A., Bronson, R.T., Bowman, M.J., Graveel, C.R., Steensma, M.R. 2018. NF1 deficiency correlates with estrogen receptor signaling and diminished survival in breast cancer. npj Breast Cancer.
  10. Jun, H.J., Appleman, V.A., Wu, H.-J., Rose, C.M., Pineda, J.J., Yeo, A.T., Delcuze, B., Lee, C., Gyuris, A., Zhu, H., Woolfenden, S., Bronisz, A., Nakano, I., Chiocca, E.A., Bronson, R.T., Ligon, K.L., Sarkaria, J.N., Gygi, S.P., Michor, F., Mitchison, T.J., Charest, A. 2018. A PDGFRα-driven mouse model of glioblastoma reveals a stathmin1-mediated mechanism of sensitivity to vinblastine. Nature Communications.
  11. Chang, A.N., Liang, Z., Dai, H.-Q., Chapdelaine-Williams, A.M., Andrews, N., Bronson, R.T., Schwer, B., Alt, F.W. 2018. Neural blastocyst complementation enables mouse forebrain organogenesis. Nature.
  12. Li, A.G., Murphy, E.C., Culhane, A.C., Powell, E., Wang, H., Bronson, R.T., Von, T., Giobbie-Hurder, A., Gelman, R.S., Briggs, K.J., Piwnica-Worms, H., Zhao, J.J., Kung, A.L., Kaelin, W.G., Livingston, D.M. 2018. BRCA1-IRIS promotes human tumor progression through PTEN blockade and HIF-1α activation. Proceedings of the National Academy of Sciences of the United States of America.
  13. Vijayakumar, V., Vanhove, A.S., Pickering, B.S., Liao, J., Tierney, B.T., Asara, J.M., Bronson, R., Watnick, P.I. 2018. Removal of a membrane anchor reveals the opposing regulatory functions of Vibrio cholerae glucose-specific enzyme IIA in biofilms and the mammalian intestine. mBio.
  14. Sinkevicius, K.W., Bellaria, K.J., Barrios, J., Pessina, P., Gupta, M., Brainson, C.F., Bronson, R.T., Kim, C.F. 2018. E-cadherin loss accelerates tumor progression and metastasis in a mouse model of lung adenocarcinoma. American Journal of Respiratory Cell and Molecular Biology.
  15. Qin, Y., Garrison, B.S., Ma, W., Wang, R., Jiang, A., Li, J., Mistry, M., Bronson, R.T., Santoro, D., Franco, C., Robinton, D.A., Stevens, B., Rossi, D.J., Lu, C., Springer, T.A. 2018. A Milieu Molecule for TGF-β Required for Microglia Function in the Nervous System. Cell.
  16. Panchamoorthy, G., Jin, C., Raina, D., Bharti, A., Yamamoto, M., Adeebge, D., Zhao, Q., Bronson, R., Jiang, S., Li, L., Suzuki, Y., Tagde, A., Ghoroghchian, P.P., Wong, K.-K., Kharbanda, S., Kufe, D. 2018. Targeting the human MUC1-C oncoprotein with an antibody-drug conjugate. JCI insight.
  17. Takahashi, N., Chen, H.-Y., Harris, I.S., Stover, D.G., Selfors, L.M., Bronson, R.T., Deraedt, T., Cichowski, K., Welm, A.L., Mori, Y., Mills, G.B., Brugge, J.S. 2018. Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Cancer Cell.
  18. Martinot, A.J., Abbink, P., Afacan, O., Prohl, A.K., Bronson, R., Hecht, J.L., Borducchi, E.N., Larocca, R.A., Peterson, R.L., Rinaldi, W., Ferguson, M., Didier, P.J., Weiss, D., Lewis, M.G., De La Barrera, R.A., Yang, E., Warfield, S.K., Barouch, D.H. 2018. Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys. Cell.
  19. Xu, H., Lee, M.-S., Tsai, P.-Y., Adler, A.S., Curry, N.L., Challa, S., Freinkman, E., Hitchcock, D.S., Copps, K.D., White, M.F., Bronson, R.T., Marcotrigiano, M., Wu, Y., Clish, C.B., Kalaany, N.Y. 2018. Ablation of insulin receptor substrates 1 and 2 suppresses Kras-driven lung tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America.
  20. McBrayer, S.K., Olenchock, B.A., DiNatale, G.J., Shi, D.D., Khanal, J., Jennings, R.B., Novak, J.S., Oser, M.G., Robbins, A.K., Modiste, R., Bonal, D., Moslehi, J., Bronson, R.T., Neuberg, D., Nguyen, Q.-D., Signoretti, S., Losman, J.-A., Kaelin, W.G. 2018. Autochthonous tumors driven by Rb1 loss have an ongoing requirement for the RBP2 histone demethylase. Proceedings of the National Academy of Sciences of the United States of America.

General Research Interests

  • Pathology of mutant mice
  • Pathology of aging
  • Cancer pathobiology

Research Interests by Area

Other Areas of Research
  • Mutant Mouse pathology