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Raymond K. Kudej - PhD, DVM, DACVS

Raymond K. Kudej
Associate Professor
Clinical Soft Tissue Surgery, Ischemia Tolerance
Soft Tissue Surgery

Campus Phone:



  • Post-Doctorate - Harvard Medical School - 1994-1996
  • PhD - Iowa State University - 1994
  • DVM - Iowa State University - 1987

Board Certification

  • American College of Veterinary Surgeons
  1. Zhao, Z., Kudej, R.K., Wen, H., Fefelova, N., Yan, L., Vatner, D.E., Vatner, S.F., Xie, L.-H. 2018. Antioxidant defense and protection against cardiac arrhythmias: Lessons from a mammalian hibernator (the woodchuck). FASEB Journal.
  2. Mariano, A.D., Penninck, D.G., Sutherland-Smith, J., Kudej, R.K. 2018. Ultrasonographic evaluation of the canine urinary bladder following cystotomy for treatment of urolithiasis. Journal of the American Veterinary Medical Association.
  3. Lynch, A.M., O'Toole, T.E., Rush, J.E., Rondeau, D., O'Neill, K., Kudej, R.K. 2015. Acute tracheal compression in a large breed dog due to a dorsal tracheal membrane abscess. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
  4. Yan, L., Kudej, R.K., Vatner, D.E., Vatner, S.F. 2015. Myocardial ischemic protection in natural mammalian hibernation. Basic Research in Cardiology.
  5. Li, H., Liu, T., Chen, W., Jain, M.R., Vatner, D.E., Vatner, S.F., Kudej, R.K., Yan, L. 2013. Proteomic mechanisms of cardioprotection during Mammalian hibernation in woodchucks, Marmota Monax. Journal of Proteome Research.
  6. Bravo, C., Kudej, R.K., Yuan, C., Yoon, S., Ge, H., Park, J.Y., Tian, B., Stanley, W.C., Vatner, S.F., Vatner, D.E., Yan, L. 2013. Metabolomic analysis of two different models of delayed preconditioning. Journal of Molecular and Cellular Cardiology.
  7. Kudej, R.K., Blaze, C. 2013. Pectus Excavatum. Small Animal Soft Tissue Surgery.
  8. Kudej, R.K., Fasano, M., Zhao, X., Lopaschuk, G.D., Fischer, S.K., Vatner, D.E., Vatner, S.F., Lewandowski, E.D. 2011. Second window of preconditioning normalizes palmitate use for oxidation and improves function during low-flow ischaemia. Cardiovascular Research.
  9. Zacher, L.A., Berg, J., Shaw, S.P., Kudej, R.K. 2010. Association between outcome and changes in plasma lactate concentration during presurgical treatment in dogs with gastric dilatation-volvulus: 64 cases (2002-2008). Journal of the American Veterinary Medical Association.
  10. Bretz, B., Blaze, C., Parry, N., Kudej, R.K. 2010. Ischemic postconditioning does not attenuateischemia-reperfusion injury of rabbit small intestine. Veterinary Surgery.
  11. Shen, Y.-T., Depre, C., Yan, L., Park, J.Y., Tian, B., Jain, K., Chen, L., Zhang, Y., Kudej, R.K., Zhao, X., Sadoshima, J., Vatner, D.E., Vatner, S.F. 2008. Repetitive ischemia by coronary stenosis induces a novel window of ischemic preconditioning. Circulation.
  12. Kudej, R.K., Depre, C. 2007. NO with no NOS in ischemic heart. Cardiovascular Research.
  13. Kudej, R.K., Shen, Y.-T., Peppas, A.P., Huang, C.-H., Chen, W., Yan, L., Vatner, D.E., Vatner, S.F. 2006. Obligatory role of cardiac nerves and α1-adrenergic receptors for the second window of ischemic preconditioning in conscious pigs. Circulation Research.
  14. Song, L.-S., Pi, Y., Kim, S.-J., Yatani, A., Guatimosim, S., Kudej, R.K., Zhang, Q., Cheng, H., Hittinger, L., Ghaleh, B., Vatner, D.E., Lederer, W.J., Vatner, S.F. 2005. Paradoxical cellular Ca2+ signaling in severe but compensated canine left ventricular hypertrophy. Circulation Research.
  15. O'Donnell, J.M., Kudej, R.K., LaNoue, K.F., Vatner, S.F., Lewandowski, E.D. 2004. Limited transfer of cytosolic NADH into mitochondria at high cardiac workload. American Journal of Physiology - Heart and Circulatory Physiology.
  16. Yatani, A., Kim, S.-J., Kudej, R.K., Wang, Q., Depre, C., Irie, K., Kranias, E.G., Vatner, S.F., Vatner, D.E. 2004. Insights into cardioprotection obtained from study of cellular Ca 2+ handling in myocardium of true hibernating mammals. American Journal of Physiology - Heart and Circulatory Physiology.
  17. Huang, C.-H., Vatner, S.F., Peppas, A.P., Yang, G., Kudej, R.K. 2003. Cardiac Nerves Affect Myocardial Stunning Through Reactive Oxygen and Nitric Oxide Mechanisms. Circulation Research.
  18. Kudej, R.K., Vatner, S.F. 2003. Nitric oxide-dependent vasodilation maintains blood flow in true hibernating myocardium. Journal of Molecular and Cellular Cardiology.
  19. Takagi, G., Asai, K., Vatner, S.F., Kudej, R.K., Rossi, F., Peppas, A., Takagi, I., Resuello, R.R.G., Natividad, F., Shen, Y.-T., Vatner, D.E. 2003. Gender differences on the effects of aging on cardiac and peripheral adrenergic stimulation in old conscious monkeys. American Journal of Physiology - Heart and Circulatory Physiology.
  20. Depre, C., Hase, M., Gaussin, V., Zajac, A., Wang, L., Hittinger, L., Ghaleh, B., Yu, X., Kudej, R.K., Wagner, T., Sadoshima, J., Vatner, S.F. 2002. H11 kinase is a novel mediator of myocardial hypertrophy in vivo. Circulation Research.

General Research Interests

  • Clinical veterinary soft tissue surgery
  • Minimally invasive surgery
  • Cardia, thoracic, gastrointestinal, and reconstructive surgery
  • Gastric dilatation-volvulous syndrome
  • Ischemia tolerance: metabolism

Research Interests by Organ System and Disease

Cardiovascular Diseases and Nutrition
  • Pathophysiology of ischemia reperfusion injury. Cardiac surgery; mechanisms of myocardial ischemia