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Patrick Skelly

Patrick Skelly
Professor and Associate Chair
Parasitology, Molecular & Cellular Helminthology

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Patrick J. Skelly, PhD, Professor, jointly runs the Molecular Helminthology Laboratory at the Cummings School of Veterinary Medicine with Professor Charles B. Shoemaker. A major focus of the laboratory is using newer molecular technologies, notably RNAi, to study helminth molecular and cell biology. Before coming to Tufts, Patrick was on the faculty at the Harvard School of Public Health. He received his PhD in Biochemistry in 1986 at the Australian National University from his work on the cuticle of the ectoparasite, Lucilia cuprina. Patrick is a past president of the New England Association of Parasitologists and is a member of the Ashton Cuckler New Investigator Committee of the American Society of Parasitologists.


  • PhD - Australian National University, Canberra, Australia - 1986
  • BS - University College Dublin, Ireland - 1981
  1. Nation, C.S., Da’dara, A.A., Marchant, J.K., Skelly, P.J. 2020. Schistosome migration in the definitive host. PLoS Neglected Tropical Diseases.
  2. Angeli, A., Pinteala, M., Maier, S.S., Simionescu, B.C., Da’dara, A.A., Skelly, P.J., Supuran, C.T. 2020. Sulfonamide inhibition studies of an α-carbonic anhydrase from Schistosoma mansoni, a platyhelminth parasite responsible for schistosomiasis. International Journal of Molecular Sciences.
  3. Nation, C.S., Da’Dara, A.A., Skelly, P.J. 2020. The essential schistosome tegumental ectoenzyme SmNPP5 can block NAD-induced T cell apoptosis. Virulence.
  4. Pirovich, D.B., Da'dara, A.A., Skelly, P.J. 2020. Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase enhances formation of the blood-clot lysis protein plasmin. Biology Open.
  5. Pirovich, D., Da'dara, A.A., Skelly, P.J. 2019. Why Do Intravascular Schistosomes Coat Themselves in Glycolytic Enzymes?. BioEssays.
  6. Da’dara, A.A., Angeli, A., Ferraroni, M., Supuran, C.T., Skelly, P.J. 2019. Crystal structure and chemical inhibition of essential schistosome host-interactive virulence factor carbonic anhydrase SmCA. Communications Biology.
  7. Elzoheiry, M., Da'dara, A.A., Nation, C.S., El-Beshbishi, S.N., Skelly, P.J. 2019. Schistosomes can hydrolyze proinflammatory and prothrombotic polyphosphate (polyP) via tegumental alkaline phosphatase, SmAP. Molecular and Biochemical Parasitology.
  8. Elzoheiry, M., Da'Dara, A.A., Delaforcade, A.M., El-Beshbishi, S.N., Skelly, P.J. 2018. The Essential Ectoenzyme SmNPP5 from the Human Intravascular Parasite Schistosoma mansoni is an ADPase and a Potent Inhibitor of Platelet Aggregation. Thrombosis and Haemostasis.
  9. Wang, Q., Da'Dara, A.A., Skelly, P.J. 2018. The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin. Parasites and Vectors.
  10. Elzoheiry, M., Da'dara, A.A., Bhardwaj, R., Wang, Q., Azab, M.S., El-Kholy, E.-S.I., El-Beshbishi, S.N., Skelly, P.J. 2018. Intravascular Schistosoma mansoni Cleave the Host Immune and Hemostatic Signaling Molecule Sphingosine-1-Phosphate via Tegumental Alkaline Phosphatase. Frontiers in immunology.
  11. Wang, Q., Da'dara, A.A., Skelly, P.J. 2017. The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin. Scientific Reports.
  12. Skelly, P., LoVerde, P.T. 2017. Editorial. Molecular and Biochemical Parasitology.
  13. Da'dara, A.A., Siddons, G., Icaza, M., Wang, Q., Skelly, P.J. 2017. How schistosomes alter the human serum proteome. Molecular and Biochemical Parasitology.
  14. Krautz-Peterson, G., Debatis, M., Tremblay, J.M., Oliveira, S.C., Da’dara, A.A., Skelly, P.J., Shoemaker, C.B. 2017. Schistosoma mansoni Infection of Mice, Rats and Humans Elicits a Strong Antibody Response to a Limited Number of Reduction-Sensitive Epitopes on Five Major Tegumental Membrane Proteins. PLoS Neglected Tropical Diseases.
  15. Da’dara, A.A., de Laforcade, A.M., Skelly, P.J. 2016. The impact of schistosomes and schistosomiasis on murine blood coagulation and fibrinolysis as determined by thromboelastography (TEG). Journal of Thrombosis and Thrombolysis.
  16. Da’dara, A.A., Skelly, P.J. 2015. Gene suppression in schistosomes using RNAi. Methods in Molecular Biology.
  17. Figueiredo, B.C., Da'dara, A.A., Oliveira, S.C., Skelly, P.J. 2015. Schistosomes Enhance Plasminogen Activation: The Role of Tegumental Enolase. PLoS Pathogens.
  18. Da'Dara, A.A., Skelly, P.J. 2014. Schistosomes versus platelets. Thrombosis Research.
  19. Figueiredo, B.C., Assis, N.R.G., Morais, S.B., Ricci, N.D., Pinheiro, C.S., Martins, V.P., Bicalho, R.M., Da'dara, A.A., Skelly, P.J., Oliveira, S.C. 2014. Schistosome Syntenin Partially Protects Vaccinated Mice against Schistosoma mansoni Infection. PLoS Neglected Tropical Diseases.
  20. Skelly, P.J., Da'dara, A.A., Li, X.-H., Castro-Borges, W., Wilson, R.A. 2014. Schistosome Feeding and Regurgitation. PLoS Pathogens.

General Research Interests

  • Parasitology, molecular and cellular helminthology

Selected Research Projects

  1. Gene silencing in schistosomes using RNA interference (RNAi): This research project is designed to provide a simple, powerful and widely applicable protocol for suppressing gene expression in parasitic platyhelminths (schistosomes) using RNAi and thereby to facilitate functional schistosome genomics.
  2. Molecular and Cellular Biology of the Schistosome Surface: This project is designed to identify and characterize host-interactive parasite surface molecules with a view to testing them as vaccine candidates.


DVM Curriculum

  • Veterinary Molecular Biology (VET 112), Course Director
  • Immunology (VET 109)
  • General Parasitology (VET 203)
  • Microbial Pathogenesis (VET 201)

PhD and Master’s Degree Curriculum

  • Parasite Biology (VET 652), Course Director
  • Conservation Medicine: Field and Laboratory Techniques (VET 582)

Research Interests by Area

Infectious Diseases: Prevention and Control
  • Vaccine against Schistosoma mansoni; new drugs to treat schistosomiasis
Infectious Diseases: Pathogenesis/Host Response
  • Helminth host/parasite interface and interaction

Laboratory Personnel

Find Out More about Dr. Skelly's Work

PatrickSkellyThe Most Important Disease You’ve Never Heard Of
Tufts’ veterinary school researchers are among a handful worldwide seeking a cure for a debilitating parasitic infection that afflicts over 200 million people - Read the full article on Tufts Now.