Patrick Skelly

Patrick Skelly
Professor and Associate Chair
Parasitology, Molecular & Cellular Helminthology

Campus Phone:
508-887-4348

Fax:
508-839-7911

Patrick J. Skelly, PhD, Professor, jointly runs the Molecular Helminthology Laboratory at the Cummings School of Veterinary Medicine with Professor Charles B. Shoemaker. A major focus of the laboratory is using newer molecular technologies, notably RNAi, to study helminth molecular and cell biology. Before coming to Tufts, Patrick was on the faculty at the Harvard School of Public Health. He received his PhD in Biochemistry in 1986 at the Australian National University from his work on the cuticle of the ectoparasite, Lucilia cuprina. Patrick is a past president of the New England Association of Parasitologists and is a member of the Ashton Cuckler New Investigator Committee of the American Society of Parasitologists.

Education

  • PhD - Australian National University, Canberra, Australia - 1986
  • BS - University College Dublin, Ireland - 1981
  1. Krautz-Peterson, G., Debatis, M., Tremblay, J.M., Oliveira, S.C., Da’dara, A.A., Skelly, P.J., Shoemaker, C.B. 2017. Schistosoma mansoni Infection of Mice, Rats and Humans Elicits a Strong Antibody Response to a Limited Number of Reduction-Sensitive Epitopes on Five Major Tegumental Membrane Proteins. PLoS Neglected Tropical Diseases.
  2. Da'dara, A.A., Siddons, G., Icaza, M., Wang, Q., Skelly, P.J. 2016. How schistosomes alter the human serum proteome. Molecular and Biochemical Parasitology.
  3. Da’dara, A.A., de Laforcade, A.M., Skelly, P.J. 2016. The impact of schistosomes and schistosomiasis on murine blood coagulation and fibrinolysis as determined by thromboelastography (TEG). Journal of Thrombosis and Thrombolysis.
  4. Da’dara, A.A., Skelly, P.J. 2015. Gene suppression in schistosomes using RNAi. Methods in Molecular Biology.
  5. Figueiredo, B.C., Da'dara, A.A., Oliveira, S.C., Skelly, P.J. 2015. Schistosomes Enhance Plasminogen Activation: The Role of Tegumental Enolase. PLoS Pathogens.
  6. Da'dara, A.A., Skelly, P.J. 2014. gene suppression in schistosomes using RNAi. Parasite Genomics Protocols: Second Edition.
  7. Figueiredo, B.C., Assis, N.R.G., Morais, S.B., Ricci, N.D., Pinheiro, C.S., Martins, V.P., Bicalho, R.M., Da'dara, A.A., Skelly, P.J., Oliveira, S.C. 2014. Schistosome Syntenin Partially Protects Vaccinated Mice against Schistosoma mansoni Infection. PLoS Neglected Tropical Diseases.
  8. Skelly, P.J., Da'dara, A.A., Li, X.-H., Castro-Borges, W., Wilson, R.A. 2014. Schistosome Feeding and Regurgitation. PLoS Pathogens.
  9. Da'Dara, A.A., Skelly, P.J. 2014. Schistosomes versus platelets. Thrombosis Research.
  10. Da'dara, A.A., Bhardwaj, R., Ali, Y.B.M., Skelly, P.J. 2014. Schistosome tegumental ecto-apyrase (SmATPDase1) degrades exogenous pro-inflammatory and pro-thrombotic nucleotides. PeerJ.
  11. Da’dara, A.A., Bhardwaj, R., Skelly, P.J. 2014. Schistosome apyrase SmATPDase1, but not SmATPDase2, hydrolyses exogenous ATP and ADP. Purinergic Signalling.
  12. Skelly, P.J. 2013. The use of imaging to detect schistosomes and diagnose schistosomiasis. Parasite Immunology.
  13. Da'dara, A.A., Faghiri, Z., Krautz-Peterson, G., Bhardwaj, R., Skelly, P.J. 2013. Schistosome Na, K-ATPase as a therapeutic target. Transactions of the Royal Society of Tropical Medicine and Hygiene.
  14. Da'dara, A.A., Skelly, P.J. 2012. RNA Interference as a Tool for Drug Discovery in Parasitic Flatworms. Parasitic Helminths: Targets, Screens, Drugs and Vaccines.
  15. Da'dara, A., Krautz-Peterson, G., Faghiri, Z., Skelly, P.J. 2012. Metabolite movement across the schistosome surface. Journal of Helminthology.
  16. Swain, M.T., Larkin, D.M., Caffrey, C.R., Davies, S.J., Loukas, A., Skelly, P.J., Hoffmann, K.F. 2011. Schistosoma comparative genomics: Integrating genome structure, parasite biology and anthelmintic discovery. Trends in Parasitology.
  17. Bhardwaj, R., Krautz-Peterson, G., Da'dara, A., Tzipori, S., Skelly, P.J. 2011. Tegumental phosphodiesterase SmNPP-5 is a virulence factor for schistosomes. Infection and Immunity.
  18. Bhardwaj, R., Krautz-Peterson, G., Skelly, P.J. 2011. Using RNA interference in schistosoma mansoni. Methods in Molecular Biology.
  19. Da'dara, A., Skelly, P.J. 2011. Manipulation of vascular function by blood flukes?. Blood Reviews.
  20. Bhardwaj, R., Skelly, P.J. 2011. Characterization of Schistosome Tegumental Alkaline Phosphatase (SmAP). PLoS Neglected Tropical Diseases.

General Research Interests

  • Parasitology, molecular and cellular helminthology

Selected Research Projects

  1. Gene silencing in schistosomes using RNA interference (RNAi): This research project is designed to provide a simple, powerful and widely applicable protocol for suppressing gene expression in parasitic platyhelminths (schistosomes) using RNAi and thereby to facilitate functional schistosome genomics.http://vet.tufts.edu/mhl/projects/schistosome.html
  2. Molecular and Cellular Biology of the Schistosome Surface: This project is designed to identify and characterize host-interactive parasite surface molecules with a view to testing them as vaccine candidates.http://vet.tufts.edu/mhl/projects/schistosome.html

Teaching

DVM Curriculum

  • Veterinary Molecular Biology (VET 112), Course Director
  • Immunology (VET 109)
  • General Parasitology (VET 203)
  • Microbial Pathogenesis (VET 201)

PhD and Master’s Degree Curriculum

  • Parasite Biology (VET 652), Course Director
  • Conservation Medicine: Field and Laboratory Techniques (VET 582)

Research Interests by Area

Infectious Diseases: Prevention and Control
  • Vaccine against Schistosoma mansoni; new drugs to treat schistosomiasis
Infectious Diseases: Pathogenesis/Host Response
  • Helminth host/parasite interface and interaction

Laboratory Personnel

Find Out More about Dr. Skelly's Work

PatrickSkellyThe Most Important Disease You’ve Never Heard Of
Tufts’ veterinary school researchers are among a handful worldwide seeking a cure for a debilitating parasitic infection that afflicts over 200 million people - Read the full article on Tufts Now.