Cummings School of Veterinary Medicine at Tufts University
Patrick Skelly

Professor and Associate Chair

Parasitology, Molecular & Cellular Helminthology

Campus Phone:
508-887-4348

Fax:
508-839-7911

Patrick J. Skelly, PhD, Professor, jointly runs the Molecular Helminthology Laboratory at the Cummings School of Veterinary Medicine with Professor Charles B. Shoemaker. A major focus of the laboratory is using newer molecular technologies, notably RNAi, to study helminth molecular and cell biology. Before coming to Tufts, Patrick was on the faculty at the Harvard School of Public Health. He received his PhD in Biochemistry in 1986 at the Australian National University from his work on the cuticle of the ectoparasite, Lucilia cuprina. Patrick is a past president of the New England Association of Parasitologists and is a member of the Ashton Cuckler New Investigator Committee of the American Society of Parasitologists.

Education

  • PhD - Australian National University, Canberra, Australia - 1986
  • BS - University College Dublin, Ireland - 1981

Schistosomes versus platelets

Author(s):Da'dara, A.A. | Skelly, P.J.
Publication year: 2014
Journal / Book title: Thrombosis Research

Schistosome apyrase SmATPDase1, but not SmATPDase2, hydrolyses exogenous ATP and ADP

Author(s):Da'dara, A.A. | Bhardwaj, R. | Skelly, P.J.
Publication year: 2014
Journal / Book title: Purinergic Signalling

Schistosome tegumental ecto-apyrase (SmATPDase1) degrades exogenous pro-inflammatory and pro-thrombotic nucleotides

Author(s):Da'dara, A.A. | Bhardwaj, R. | Ali, Y.B.M. | Skelly, P.J.
Publication year: 2014
Journal / Book title: PeerJ

The use of imaging to detect schistosomes and diagnose schistosomiasis

Author(s):Skelly, P.J.
Publication year: 2013
Journal / Book title: Parasite Immunology

Schistosome Na, K-ATPase as a therapeutic target

Author(s):Da'dara, A.A. | Faghiri, Z. | Krautz-Peterson, G. | Bhardwaj, R. | Skelly, P.J.
Publication year: 2013
Journal / Book title: Transactions of the Royal Society of Tropical Medicine and Hygiene

RNA Interference as a Tool for Drug Discovery in Parasitic Flatworms

Author(s):Da'dara, A.A. | Skelly, P.J.
Publication year: 2012
Journal / Book title: Parasitic Helminths: Targets, Screens, Drugs and Vaccines

Metabolite movement across the schistosome surface

Author(s):Da'dara, A. | Krautz-Peterson, G. | Faghiri, Z. | Skelly, P.J.
Publication year: 2012
Journal / Book title: Journal of Helminthology

Author(s):
Publication year:
Journal / Book title:

Tegumental phosphodiesterase SmNPP-5 is a virulence factor for schistosomes

Author(s):Bhardwaj, R. | Krautz-Peterson, G. | Da'dara, A. | Tzipori, S. | Skelly, P.J.
Publication year: 2011
Journal / Book title: Infection and Immunity

Using RNA interference in schistosoma mansoni

Author(s):Bhardwaj, R. | Krautz-Peterson, G. | Skelly, P.J.
Publication year: 2011
Journal / Book title: Methods in Molecular Biology

Manipulation of vascular function by blood flukes?

Author(s):Da'dara, A. | Skelly, P.J.
Publication year: 2011
Journal / Book title: Blood Reviews

Characterization of Schistosome Tegumental Alkaline Phosphatase (SmAP)

Author(s):Bhardwaj, R. | Skelly, P.J.
Publication year: 2011
Journal / Book title: PLoS Neglected Tropical Diseases

Schistosoma mansoni host-exposed surface antigens characterized by sera and recombinant antibodies from schistosomiasis-resistant rats

Author(s):Sepulveda, J. | Tremblay, J.M. | DeGnore, J.P. | Skelly, P.J. | Shoemaker, C.B.
Publication year: 2010
Journal / Book title: International Journal for Parasitology

The tegument of the human parasitic worm Schistosoma mansoni as an excretory organ: The surface aquaporin SmAQP is a lactate transporter

Author(s):Faghiri, Z. | Camargo, S.M.R. | Huggel, K. | Forster, I.C. | Ndegwa, D. | Verrey, F. | Skelly, P.J.
Publication year: 2010
Journal / Book title: PLoS ONE

Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host

Author(s):Krautz-Peterson, G. | Simoes, M. | Faghiri, Z. | Ndegwa, D. | Oliveira, G. | Shoemaker, C.B. | Skelly, P.J.
Publication year: 2010
Journal / Book title: PLoS Pathogens

RNA interference in schistosomes: Machinery and methodology

Author(s):Krautz-Peterson, G. | Bhardwaj, R. | Faghiri, Z. | Tararam, C.A. | Skelly, P.J.
Publication year: 2010
Journal / Book title: Parasitology

The role of tegumental aquaporin from the human parasitic worm, Schistosoma mansoni, in osmoregulation and drug uptake

Author(s):Faghiri, Z. | Skelly, P.J.
Publication year: 2009
Journal / Book title: FASEB Journal

Imaging schistosomes in vivo

Author(s):Krautz-Peterson, G. | Ndegwa, D. | Vasquez, K. | Korideck, H. | Zhang, J. | Peterson, J.D. | Skelly, P.J.
Publication year: 2009
Journal / Book title: FASEB Journal

Purinergic signaling and immune modulation at the schistosome surface?

Author(s):Bhardwaj, R. | Skelly, P.J.
Publication year: 2009
Journal / Book title: Trends in Parasitology

Subversion of complement by hematophagous parasites

Author(s):Schroeder, H. | Skelly, P.J. | Zipfel, P.F. | Losson, B. | Vanderplasschen, A.
Publication year: 2009
Journal / Book title: Developmental and Comparative Immunology

General Research Interests

  • Parasitology, molecular and cellular helminthology

Selected Research Projects

  1. Gene silencing in schistosomes using RNA interference (RNAi): This research project is designed to provide a simple, powerful and widely applicable protocol for suppressing gene expression in parasitic platyhelminths (schistosomes) using RNAi and thereby to facilitate functional schistosome genomics.http://vet.tufts.edu/mhl/projects/schistosome.html
  2. Molecular and Cellular Biology of the Schistosome Surface: This project is designed to identify and characterize host-interactive parasite surface molecules with a view to testing them as vaccine candidates.http://vet.tufts.edu/mhl/projects/schistosome.html

Teaching

DVM Curriculum

  • Veterinary Molecular Biology (VET 112), Course Director
  • Immunology (VET 109)
  • General Parasitology (VET 203)
  • Microbial Pathogenesis (VET 201)

PhD and Master’s Degree Curriculum

  • Parasite Biology (VET 652), Course Director
  • Conservation Medicine: Field and Laboratory Techniques (VET 582)

Research Interests by Area

Infectious Diseases: Prevention and Control
  • Vaccine against Schistosoma mansoni; new drugs to treat schistosomiasis
Infectious Diseases: Pathogenesis/Host Response
  • Helminth host/parasite interface and interaction

Laboratory Personnel

Find Out More about Dr. Skelly's Work

PatrickSkellyThe Most Important Disease You’ve Never Heard Of
Tufts’ veterinary school researchers are among a handful worldwide seeking a cure for a debilitating parasitic infection that afflicts over 200 million people - Read the full article on Tufts Now.