Patrick J. Skelly, PhD, Professor, jointly runs the Molecular Helminthology Laboratory at the Cummings School of Veterinary Medicine with Professor Charles B. Shoemaker. A major focus of the laboratory is using newer molecular technologies, notably RNAi, to study helminth molecular and cell biology. Before coming to Tufts, Patrick was on the faculty at the Harvard School of Public Health. He received his PhD in Biochemistry in 1986 at the Australian National University from his work on the cuticle of the ectoparasite, Lucilia cuprina. Patrick is a past president of the New England Association of Parasitologists and is a member of the Ashton Cuckler New Investigator Committee of the American Society of Parasitologists.
PhD - Australian National University, Canberra, Australia - 1986
BS - University College Dublin, Ireland - 1981
Da'dara AA, Bhardwaj R, Ali YB, Skelly PJ. Schistosome tegumental ecto-apyrase (SmATPDase1) degrades exogenous pro-inflammatory and pro-thrombotic nucleotides. PeerJ. 2014 Mar 18;2:e316. doi: 10.7717/peerj.316.
Skelly PJ. The use of imaging to detect schistosomes and diagnose schistosomiasis. Parasite Immunol. 2013 Sep-Oct;35(9-10):295-301. doi: 10.1111/pim.12040.
Sex and the Single Schistosome Skelly PJ.; Natural History. 2008; Jun;117(5):22-27
General Research Interests
Parasitology, molecular and cellular helminthology
Selected Research Projects
Gene silencing in schistosomes using RNA interference (RNAi): This research project is designed to provide a simple, powerful and widely applicable protocol for suppressing gene expression in parasitic platyhelminths (schistosomes) using RNAi and thereby to facilitate functional schistosome genomics.http://vet.tufts.edu/mhl/projects/schistosome.html
Molecular and Cellular Biology of the Schistosome Surface: This project is designed to identify and characterize host-interactive parasite surface molecules with a view to testing them as vaccine candidates.http://vet.tufts.edu/mhl/projects/schistosome.html
Veterinary Molecular Biology (VET 112), Course Director
Immunology (VET 109)
General Parasitology (VET 203)
Microbial Pathogenesis (VET 201)
PhD and Master’s Degree Curriculum
Parasite Biology (VET 652), Course Director
Conservation Medicine: Field and Laboratory Techniques (VET 582)
Research Interests by Area
Infectious Diseases: Prevention and Control
Vaccine against Schistosoma mansoni; new drugs to treat schistosomiasis