Nicholas Frank - DVM, PhD, DACVIM

Nicholas Frank
Professor & Associate Dean for Academic Affairs
Internal Medicine, Endocrinology, Obesity, and Laminitis
Large Animal Internal Medicine

Campus Phone:
508-887-4615

Alt Phone:
508-839-5395 Hospital

Fax:
508-839-7922

Education

  • BSc. Hons. Biology University of North Carolina 1989
  • DVM Purdue University 1993
  • PhD Purdue University 2002

Board Certification

  • Diplomate ACVIM
  1. Banse HE, Holbrook TC, Frank N, McFarlane D. 2016. Relationship of skeletal muscle inflammation with obesity and obesity-associated hyperinsulinemia in horses. Can J Vet Res. 2016 Jul;80(3):217-24
  2. Restifo MM, Frank N, Hermida P, Sanchez-Londoño A. 2016. Effects of withholding feed on thyrotropin-releasing hormone stimulation test results and effects of combined testing on oral sugar test and thyrotropin-releasing hormone stimulation test results in horses. Am J Vet Res. 2016 Jul;77(7):738-48
  3. Banse HE, Frank N, Kwong GP, McFarlane D. 2015. Relationship of oxidative stress in skeletal muscle with obesity and obesity-associated hyperinsulinemia in horses. Can J Vet Res. 2015 Oct;79(4):329-38
  4. Goodale L, Frank N, Hermida P, D'Oench S. 2015. Evaluation of a thyrotropin-releasing hormone solution stored at room temperature for pituitary pars intermedia dysfunction testing in horses. Am J Vet Res. 2015 May;76(5):437-44
  5. Tadros EM, Frank N, De Witte FG, Boston RC. 2013. Effects of intravenous lipopolysaccharide infusion on glucose and insulin dynamics in horses with equine metabolic syndrome. Am J Vet Res. 2013 Jul;74(7):1020-9
  6. Tadros EM, Frank N, Donnell RL. 2013. Effects of equine metabolic syndrome on inflammatory responses of horses to intravenous lipopolysaccharide infusion. Am J Vet Res. 2013 Jul;74(7):1010-9
  7. Whiteman JP, Frank N, Greller KA, Harlow HJ, Ben-David M. 2013. Characterization of blood lipoproteins and validation of cholesterol and triacylglycerol assays for free-ranging polar bears (Ursus maritimus). J Vet Diagn Invest. 2013 May;25(3):423-7
  8. Tadros EM, Frank N, Newkirk KM, Donnell RL, Horohov DW. 2012. Effects of a "two-hit" model of organ damage on the systemic inflammatory response and development of laminitis in horses. Vet Immunol Immunopathol. 2012 Nov 15;150(1-2):90-100
  9. Tadros EM, Frank N. 2012. Effects of continuous or intermittent lipopolysaccharide administration for 48 hours on the systemic inflammatory response in horses. Am J Vet Res. 2012 Sep;73(9):1394-402
  10. St George RJ, Carlson-Kuhta P, Burchiel KJ, Hogarth P, Frank N, Horak FB. 2012. The effects of subthalamic and pallidal deep brain stimulation on postural responses in patients with Parkinson disease. J Neurosurg. 2012 Jun;116(6):1347-56
  11. Frank N. 2011. Equine metabolic syndrome. Vet Clin North Am Equine Pract. 2011 Apr;27(1):73-92
  12. Buchheit TM, Sommardahl CS, Frank N, Roberson JR. 2010. Use of a constant rate infusion of insulin for the treatment of hyperglycemic, hypernatremic, hyperosmolar syndrome in an alpaca cria. J Am Vet Med Assoc. 2010 Mar 01;236(5):562-6
  13. Tóth F, Frank N, Geor RJ, Boston RC. 2010. Effects of pretreatment with dexamethasone or levothyroxine sodium on endotoxin-induced alterations in glucose and insulin dynamics in horses. Am J Vet Res. 2010 Jan;71(1):60-8
  14. Carter RA, McCutcheon LJ, George LA, Smith TL, Frank N, Geor RJ. 2009. Effects of diet-induced weight gain on insulin sensitivity and plasma hormone and lipid concentrations in horses. Am J Vet Res. 2009 Oct;70(10):1250-8
  15. Kalck KA, Frank N, Elliott SB, Boston RC. 2009. Effects of low-dose oligofructose treatment administered via nasogastric intubation on induction of laminitis and associated alterations in glucose and insulin dynamics in horses. Am J Vet Res. 2009 May;70(5):624-32
  16. Geor R, Frank N. 2009. Metabolic syndrome-From human organ disease to laminar failure in equids. Vet Immunol Immunopathol. 2009 Jun 15;129(3-4):151-4
  17. Tóth F, Frank N, Elliott SB, Geor RJ, Boston RC. 2008. Effects of an intravenous endotoxin challenge on glucose and insulin dynamics in horses. Am J Vet Res. 2008 Jan;69(1):82-8
  18. Frank N, Elliott SB, Boston RC. 2008. Effects of long-term oral administration of levothyroxine sodium on glucose dynamics in healthy adult horses. Am J Vet Res. 2008 Jan;69(1):76-81
  19. Frank N, Buchanan BR, Elliott SB. 2008. Effects of long-term oral administration of levothyroxine sodium on serum thyroid hormone concentrations, clinicopathologic variables, and echocardiographic measurements in healthy adult horses. Am J Vet Res. 2008 Jan;69(1):68-75
  20. Andrews FM, Frank N, Sommardahl CS, Buchanan BR, Elliott SB, Allen VA. 2006. Effects of intravenously administrated omeprazole on gastric juice pH and gastric ulcer scores in adult horses. J Vet Intern Med. 2006 Sep-Oct;20(5):1202-6
  21. Frank N, Andrews FM, Sommardahl CS, Eiler H, Rohrbach BW, Donnell RL. 2006. Evaluation of the combined dexamethasone suppression/ thyrotropin-releasing hormone stimulation test for detection of pars intermedia pituitary adenomas in horses. J Vet Intern Med. 2006 Jul-Aug;20(4):987-93
  22. Coffer NJ, Frank N, Elliott SB, Young CD, van Amstel SR. 2006. Effects of dexamethasone and isoflupredone acetate on plasma potassium concentrations and other biochemical measurements in dairy cows in early lactation. Am J Vet Res. 2006 Jul;67(7):1244-51
  23. Frank N, Elliott SB, Brandt LE, Keisler DH. 2006. Physical characteristics, blood hormone concentrations, and plasma lipid concentrations in obese horses with insulin resistance. J Am Vet Med Assoc. 2006 May 01;228(9):1383-90
  24. Frank N, Elliott SB, Allin SB, Ramsay EC. 2006. Blood lipid concentrations and lipoprotein patterns in captive and wild American black bears (Ursus americanus). Am J Vet Res. 2006 Feb;67(2):335-41
  25. Frank N, Andrews FM, Elliott SB, Lew J. 2005. Effects of dietary oils on the development of gastric ulcers in mares. Am J Vet Res. 2005 Nov;66(11):2006-11
  26. Eiler H, Frank N, Andrews FM, Oliver JW, Fecteau KA. 2005. Physiologic assessment of blood glucose homeostasis via combined intravenous glucose and insulin testing in horses. Am J Vet Res. 2005 Sep;66(9):1598-604
  27. Morandi F, Frank N, Avenell J, Daniel GB. 2005. Quantitative assessment of hepatic function by means of 99mTc-mebrofenin in healthy horses. J Vet Intern Med. 2005 Sep-Oct;19(5):751-5
  28. Frank N, Sommardahl CS, Eiler H, Webb LL, Denhart JW, Boston RC. 2005. Effects of oral administration of levothyroxine sodium on concentrations of plasma lipids, concentration and composition of very-low-density lipoproteins, and glucose dynamics in healthy adult mares. Am J Vet Res. 2005 Jun;66(6):1032-8
  29. Sommardahl CS, Frank N, Elliott SB, Webb LL, Refsal KR, Denhart JW, Thompson DL. 2005. Effects of oral administration of levothyroxine sodium on serum concentrations of thyroid gland hormones and responses to injections of thyrotropin-releasing hormone in healthy adult mares. Am J Vet Res. 2005 Jun;66(6):1025-31
  30. Frank N, Sojka J, Messer NT. 2002. Equine thyroid dysfunction. Vet Clin North Am Equine Pract. 2002 Aug;18(2):305-19, vii
  31. Sakamoto K, Kiupel M, Frank N, March PA. 2004. Vertebral malformation, syringomyelia, and ventricular septal defect in a dromedary camel (Camelius dromedarius). J Vet Diagn Invest. 2004 Jul;16(4):337-40
  32. Frank N, Sojka JE, Patterson BW, Wood KV, Bonham CC, Latour MA. 2003. Effect of hypothyroidism on kinetics of metabolism of very-low-density lipoprotein in mares. Am J Vet Res. 2003 Aug;64(8):1052-8
  33. Frank N, Sojka JE, Latour MA. 2003. Effects of hypothyroidism and withholding of feed on plasma lipid concentrations, concentration and composition of very-low-density lipoprotein, and plasma lipase activity in horses. Am J Vet Res. 2003 Jul;64(7):823-8
  34. Frank N, Sojka JE, Latour MA. 2002. Effect of withholding feed on concentration and composition of plasma very low density lipoprotein and serum nonesterified fatty acids in horses. Am J Vet Res. 2002 Jul;63(7):1018-21
  35. Morisset S, Hawkins JF, Frank N, Sojka JE, Berg D, Blevins WE. 2002. Surgical management of a ureteral defect with ureterorrhaphy and of ureteritis with ureteroneocystostomy in a foal. J Am Vet Med Assoc. 2002 Feb 01;220(3):354-8, 323

General Research Interests

  • Internal medicine
  • Comparative endocrinology
  • Metabolism
  • Nutrition
  • Gastroenterology

Selected Research Projects

  • Endotoxemia as a predisposing factor for laminitis
  • Effects of clinical endotoxemia on glucose metabolism in horses
  • Levothyroxine as a treatment for insulin resistance
  • Effects of resting insulin sensitivity on the acute response to endotoxin in horses
  • Effects of combining endotoxemia and alimentary carbohydrate overload on glucose and insulin dynamics in horses
  • Improved diagnosis and monitoring of equine endocrine disorders
  • Development of an optimal protocol for evaluating insulin secretion and sensitivity in horses
  • A study of the alterations in glucose and lipid metabolism that accompany the development of laminitis in horses
  • Evaluating the effects of endotoxin on glucose dynamics in horses using intravenous glucose tolerance test and euglycemic hyperinsulinemic clamp techniques

Research and Clinical Interests

  • Diagnosis and management of endocrine disorders
  • Equine Metabolic Syndrome
  • Cushings disease
  • Laminitis
  • Endotoxemia
  • Obesity
  • Insulin resistance
  • Diabetes mellitus
  • Incretin hormones
  • Adipokines
  • Electrolyte disorders
  • Nutritional diseases
  • Gastroenterology
  • Geriatric medicine
  • Neonatology

Research Interests by Area

Spontaneous Animal Disease Models
  • Animal models of obesity, metabolic syndrome, equine Cushing's, and aging

Research Interests by Organ System and Disease

Nutritional Basis of Diseases
  • Obesity, insulin resistance, and beta cell function and lipid metabolism.
Endocrinology
  • Insulin resistance, diabetes mellitis, hyperadrenocorticism. Laminitis in horses. Obesity.

Professional organizations

  • American Veterinary Medical Association
  • American College of Veterinary Internal Medicine

Research Sponsor Interest

  • American College of Veterinary Internal Medicine Foundation
  • American Quarter Horse Foundation
  • Grayson Jockey Club Foundation
  • United States Equestrian Federation