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Nicholas Frank - DVM, PhD, DACVIM

Nicholas Frank
Professor & Associate Dean for Academic Affairs
Internal Medicine, Endocrinology, Obesity, and Laminitis
Large Animal Internal Medicine

Campus Phone:

Alt Phone:
508-839-5395 Hospital



  • BSc. Hons. Biology University of North Carolina 1989
  • DVM Purdue University 1993
  • PhD Purdue University 2002

Board Certification

  • Diplomate ACVIM
  1. Frank, N., Andrews, F.M., Elliott, S.B., Lewt, J., Boston, R.C. 2005. Effects of rice bran oil on plasma lipid concentrations, lipoprotein composition, and glucose dynamics in mares. Journal of Animal Science.

General Research Interests

  • Internal medicine
  • Comparative endocrinology
  • Metabolism
  • Nutrition
  • Gastroenterology

Selected Research Projects

  • Endotoxemia as a predisposing factor for laminitis
  • Effects of clinical endotoxemia on glucose metabolism in horses
  • Levothyroxine as a treatment for insulin resistance
  • Effects of resting insulin sensitivity on the acute response to endotoxin in horses
  • Effects of combining endotoxemia and alimentary carbohydrate overload on glucose and insulin dynamics in horses
  • Improved diagnosis and monitoring of equine endocrine disorders
  • Development of an optimal protocol for evaluating insulin secretion and sensitivity in horses
  • A study of the alterations in glucose and lipid metabolism that accompany the development of laminitis in horses
  • Evaluating the effects of endotoxin on glucose dynamics in horses using intravenous glucose tolerance test and euglycemic hyperinsulinemic clamp techniques

Research and Clinical Interests

  • Diagnosis and management of endocrine disorders
  • Equine Metabolic Syndrome
  • Cushings disease
  • Laminitis
  • Endotoxemia
  • Obesity
  • Insulin resistance
  • Diabetes mellitus
  • Incretin hormones
  • Adipokines
  • Electrolyte disorders
  • Nutritional diseases
  • Gastroenterology
  • Geriatric medicine
  • Neonatology

Research Interests by Area

Spontaneous Animal Disease Models
  • Animal models of obesity, metabolic syndrome, equine Cushing's, and aging

Research Interests by Organ System and Disease

Nutritional Basis of Diseases
  • Obesity, insulin resistance, and beta cell function and lipid metabolism.
  • Insulin resistance, diabetes mellitis, hyperadrenocorticism. Laminitis in horses. Obesity.

Professional organizations

  • American Veterinary Medical Association
  • American College of Veterinary Internal Medicine

Research Sponsor Interest

  • American College of Veterinary Internal Medicine Foundation
  • American Quarter Horse Foundation
  • Grayson Jockey Club Foundation
  • United States Equestrian Federation