Nicholas Frank - DVM, PhD, DACVIM

Nicholas Frank
Professor & Department Chair
Department Chair; Internal Medicine, Endocrinology, Obesity, and Laminitis
Large Animal Internal Medicine

Campus Phone:
508-887-4615

Alt Phone:
508-839-5395 Hospital

Fax:
508-839-7922

Education

  • BSc. Hons. Biology University of North Carolina 1989
  • DVM Purdue University 1993
  • PhD Purdue University 2002

Board Certification

  • Diplomate ACVIM

Relationship of skeletal muscle inflammation with obesity and obesity-associated hyperinsulinemia in horses

Author(s):Banse, H.E. | Holbrook, T.C. | Frank, N. | McFarlane, D.
Publication year: 2016
Journal / Book title: Canadian Journal of Veterinary Research

Comparison of Plasma Active Glucagon-Like Peptide 1 Concentrations in Normal Horses and Those With Equine Metabolic Syndrome and in Horses Placed on a High-Grain Diet

Author(s):Chameroy, K.A. | Frank, N. | Elliott, S.B. | Boston, R.C.
Publication year: 2016
Journal / Book title: Journal of Equine Veterinary Science

Effect of Age, Season, Body Condition, and Endocrine Status on Serum Free Cortisol Fraction and Insulin Concentration in Horses

Author(s):Hart, K.A. | Wochele, D.M. | Norton, N.A. | Mcfarlane, D. | Wooldridge, A.A. | Frank, N.
Publication year: 2016
Journal / Book title: Journal of Veterinary Internal Medicine

Effects of Therapeutic Riding on Measures of Stress in Horses

Author(s):McKinney, C. | Mueller, M.K. | Frank, N.
Publication year: 2015
Journal / Book title: Journal of Equine Veterinary Science

Relationship of oxidative stress in skeletal muscle with obesity and obesity-associated hyperinsulinemia in horses

Author(s):Banse, H.E. | Frank, N. | Kwong, G.P.S. | McFarlane, D.
Publication year: 2015
Journal / Book title: Canadian Journal of Veterinary Research

Evaluation of a thyrotropin-releasing hormone solution stored at room temperature for pituitary pars intermedia dysfunction testing in horses

Author(s):Goodale, L. | Frank, N. | Hermida, P. | D’Oench, S.
Publication year: 2015
Journal / Book title: American Journal of Veterinary Research

Equine Metabolic Syndrome

Author(s):Frank, N.
Publication year: 2014
Journal / Book title: Robinson's Current Therapy in Equine Medicine: Seventh Edition

Pituitary Pars Intermedia Dysfunction

Author(s):Frank, N.
Publication year: 2014
Journal / Book title: Robinson's Current Therapy in Equine Medicine: Seventh Edition

Insulin dysregulation

Author(s):Frank, N. | Tadros, E.M.
Publication year: 2014
Journal / Book title: Equine Veterinary Journal

Current best practice in clinical management of equine endocrine patients

Author(s):Frank, N. | Geor, R.
Publication year: 2014
Journal / Book title: Equine Veterinary Education

Assessment of insulin and glucose dynamics by using an oral sugar test in horses

Author(s):Schuver, A. | Frank, N. | Chameroy, K.A. | Elliott, S.B.
Publication year: 2014
Journal / Book title: Journal of Equine Veterinary Science

Inflammatory cytokine gene expression in blood during the development of oligofructose-induced laminitis in horses

Author(s):Tadros, E.M. | Frank, N. | Horohov, D.W.
Publication year: 2013
Journal / Book title: Journal of Equine Veterinary Science

Effects of intravenous lipopolysaccharide infusion on glucose and insulin dynamics in horses with equine metabolic syndrome

Author(s):Tadros, E.M. | Frank, N. | De Witte, F.G. | Boston, R.C.
Publication year: 2013
Journal / Book title: American Journal of Veterinary Research

Effects of equine metabolic syndrome on inflammatory responses of horses to intravenous lipopolysaccharide infusion

Author(s):Tadros, E.M. | Frank, N. | Donnell, R.L.
Publication year: 2013
Journal / Book title: American Journal of Veterinary Research

Characterization of blood lipoproteins and validation of cholesterol and triacylglycerol assays for free-ranging polar bears (Ursus maritimus)

Author(s):Whiteman, J.P. | Frank, N. | Greller, K.A. | Harlow, H.J. | Ben-David, M.
Publication year: 2013
Journal / Book title: Journal of Veterinary Diagnostic Investigation

Endocrinology

Author(s):Frank, N.
Publication year: 2013
Journal / Book title: Equine Medicine, Surgery and Reproduction: Second Edition

Endocrine disorders and laminitis

Author(s):Tadros, E.M. | Frank, N.
Publication year: 2013
Journal / Book title: Equine Veterinary Education

Effects of a "two-hit" model of organ damage on the systemic inflammatory response and development of laminitis in horses

Author(s):Tadros, E.M. | Frank, N. | Newkirk, K.M. | Donnell, R.L. | Horohov, D.W.
Publication year: 2012
Journal / Book title: Veterinary Immunology and Immunopathology

Effects of continuous or intermittent lipopolysaccharide administration for 48 hours on the systemic inflammatory response in horses

Author(s):Tadros, E.M. | Frank, N.
Publication year: 2012
Journal / Book title: American Journal of Veterinary Research

Association of Asinine Herpesvirus-5 with Pyogranulomatous Pneumonia in a Mare

Author(s):De Witte, F.G. | Frank, N. | Wilkes, R.P. | Novak, J.M.
Publication year: 2012
Journal / Book title: Journal of Veterinary Internal Medicine

General Research Interests

  • Internal medicine
  • Comparative endocrinology
  • Metabolism
  • Nutrition
  • Gastroenterology

Selected Research Projects

  • Endotoxemia as a predisposing factor for laminitis
  • Effects of clinical endotoxemia on glucose metabolism in horses
  • Levothyroxine as a treatment for insulin resistance
  • Effects of resting insulin sensitivity on the acute response to endotoxin in horses
  • Effects of combining endotoxemia and alimentary carbohydrate overload on glucose and insulin dynamics in horses
  • Improved diagnosis and monitoring of equine endocrine disorders
  • Development of an optimal protocol for evaluating insulin secretion and sensitivity in horses
  • A study of the alterations in glucose and lipid metabolism that accompany the development of laminitis in horses
  • Evaluating the effects of endotoxin on glucose dynamics in horses using intravenous glucose tolerance test and euglycemic hyperinsulinemic clamp techniques

Research Interests by Area

Spontaneous Animal Disease Models
  • Animal models of obesity, metabolic syndrome, equine Cushing's, and aging

Research Interests by Organ System and Disease

Nutritional Basis of Diseases
  • Obesity, insulin resistance, and beta cell function and lipid metabolism.
Endocrinology
  • Insulin resistance, diabetes mellitis, hyperadrenocorticism. Laminitis in horses. Obesity.

Professional organizations

  • American Veterinary Medical Association
  • American College of Veterinary Internal Medicine

Research Sponsor Interest

  • American College of Veterinary Internal Medicine Foundation
  • American Quarter Horse Foundation
  • Grayson Jockey Club Foundation
  • United States Equestrian Federation