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M. Sawkat Anwer - DMVH, PhD

M. Sawkat Anwer
Distinguished Professor
Associate Dean for Research
Liver Disease
Molecular Physiology and Pharmacology

Campus Phone:
508-839-8788

Fax:
508-839-8787

Education

  • DMVH - Munich University - 1980
  • PhD - Kansas State University - 1973
  • MS - Dhaka University - 1968
  1. Park SW, Webster CRL, Anwer MS. 2017. Mechanism of inhibition of taurolithocholate-induced retrieval of plasma membrane MRP2 by cyclic AMP and tauroursodeoxycholate. Physiol Rep. 2017 Dec;5(23):
  2. Sayeed MA, Smallwood C, Imam T, Mahmud R, Hasan RB, Hasan M, Anwer MS, Rashid MH, Hoque MA. 2017. Assessment of hygienic conditions of live bird markets on avian influenza in Chittagong metro, Bangladesh. Prev Vet Med. 2017 Jul 01;142:7-15
  3. Anwer MS. 2016. GI Research in a Veterinary School. Cell Mol Gastroenterol Hepatol. 2016 Nov;2(6):704-706
  4. Schonhoff CM, Park SW, Webster CR, Anwer MS. 2016. p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2. Am J Physiol Gastrointest Liver Physiol. 2016 Jun 01;310(11):G999-G1005
  5. Webster CR, Anwer MS. 2016. Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells. Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G865-73
  6. Webster CR, Johnston AN, Anwer MS. 2014. Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2014 Dec 15;307(12):G1207-15
  7. Park SW, Schonhoff CM, Webster CR, Anwer MS. 2014. Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15;307(8):G863-70
  8. Anwer MS. 2014. Role of protein kinase C isoforms in bile formation and cholestasis. Hepatology. 2014 Sep;60(3):1090-7
  9. Anwer MS, Stieger B. 2014. Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters. Pflugers Arch. 2014 Jan;466(1):77-89
  10. Ramasamy U, Anwer MS, Schonhoff CM. 2013. Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 01;305(7):G513-9
  11. Pumphrey SA, Pizzirani S, Pirie CG, Anwer MS, Logvinenko T. 2013. Western blot patterns of serum autoantibodies against optic nerve antigens in dogs with goniodysgenesis-related glaucoma. Am J Vet Res. 2013 Apr;74(4):621-8
  12. Schonhoff CM, Webster CR, Anwer MS. 2013. Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cϵ in HUH-NTCP Cells. Hepatology. 2013 Jul;58(1):284-92
  13. Anwer MS, Hashim R, Khan FA, Ijaz A. 2012. Frequency of conversion to overt hypothyroidism in patients with and without subclinical hypothyroidism. J Ayub Med Coll Abbottabad. 2012 Jul-Dec;24(3-4):166-70
  14. Park SW, Schonhoff CM, Webster CR, Anwer MS. 2012. Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 01;303(5):G657-65
  15. Anwer MS. 2012. INTRACELLULAR SIGNALING BY BILE ACIDS. J Biosci (Rajshari). 2012;20:1-23
  16. Johnston A, Ponzetti K, Anwer MS, Webster CR. 2011. cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G385-400
  17. Schonhoff CM, Ramasamy U, Anwer MS. 2011. Nitric oxide-mediated inhibition of taurocholate uptake involves S-nitrosylation of NTCP. Am J Physiol Gastrointest Liver Physiol. 2011 Feb;300(2):G364-70
  18. Hohenester S, Gates A, Wimmer R, Beuers U, Anwer MS, Rust C, Webster CR. 2010. Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. J Hepatol. 2010 Nov;53(5):918-26
  19. Schonhoff CM, Webster CR, Anwer MS. 2010. Cyclic AMP stimulates Mrp2 translocation by activating p38{alpha} MAPK in hepatic cells. Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G667-74
  20. Ponzetti K, King M, Gates A, Anwer MS, Webster CR. 2010. Cyclic AMP-guanine exchange factor activation inhibits JNK-dependent lipopolysaccharide-induced apoptosis in rat hepatocytes. Hepat Med. 2010 Jan;2010(2):1-11

General Research Interests

Functional abnormalities associated with various liver diseases lead to accumulation of toxic products (such as bilirubin in jaundice and bile acids) in blood and premature death of liver cells. One of the major determinants is the inability of the liver to properly regulate bile acid transport from blood to bile. Studies are conducted to better understand the mechanisms regulating bile acid transport. Specifically, studies are designed to determine the role of various kinases and phosphatases in the regulation of bile acid transport using primary hepatocytes, hepatic cell lines and transgenic mice. Techniques used are cell culture, transfection of cell lines, solute uptake, western blots, protein phosphorylation, Protein S-nitrosylation, etc.

Selected Research Projects

  • Role of protein kinase Cs in the regulation of hepatic transporters.
  • Mechanism of taurolithocholate-induced cholestasis.
  • Role of protein S-nitrosylation in sepsis-induced cholestasis.
  • Mechanisms of anticholestatic effects of cAMP and tauroursodeoxycholate.

Research and Clinical Interests

  • Hepatic diseases
  • Pharmacokinetics

Research Interests by Area

Hepatic Diseases
  • Mechanism of bile formation and cholestasis
Training Grants
  • NIH Short term research training for DVM students

Major Specialized Equipment

  • Fluorescent spectrophotometers
  • UV-VIS spectrophotometers
  • Scintillation Counter
  • Gel-Electrophoresis (1D & 2D) apparatus
  • Film developer
  • Cell culture facility
  • Fluroescence microscope

Lab Personnel

  • Holly Jameson, Sr. Research Coordinator
  • Ariel Hobson, Research Technician
  • Umadevi Ramasamy, Research Technician
  • Sewon Park, Graduate Student
  • Christopher Schonhoff, Ph.D., Research Assistant Professor