M. Sawkat Anwer

M. Sawkat Anwer
Distinguished Professor
Associate Dean for Research
Liver Disease
Molecular Physiology and Pharmacology

Campus Phone:
508-839-8788

Fax:
508-839-8787

Education

  • DMVH - Munich University - 1980
  • PhD - Kansas State University - 1973
  • MS - Dhaka University - 1968
  1. Anwer MS. 2016. GI Research in a Veterinary School. Cell Mol Gastroenterol Hepatol. 2016 Nov;2(6):704-706
  2. Schonhoff CM, Park SW, Webster CR, Anwer MS. 2016. p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2. Am J Physiol Gastrointest Liver Physiol. 2016 Jun 01;310(11):G999-G1005
  3. Webster CR, Anwer MS. 2016. Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells. Am J Physiol Gastrointest Liver Physiol. 2016 May 15;310(10):G865-73
  4. Webster CR, Johnston AN, Anwer MS. 2014. Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2014 Dec 15;307(12):G1207-15
  5. Park SW, Schonhoff CM, Webster CR, Anwer MS. 2014. Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane. Am J Physiol Gastrointest Liver Physiol. 2014 Oct 15;307(8):G863-70
  6. Anwer MS. 2014. Role of protein kinase C isoforms in bile formation and cholestasis. Hepatology. 2014 Sep;60(3):1090-7
  7. Anwer MS, Stieger B. 2014. Sodium-dependent bile salt transporters of the SLC10A transporter family: more than solute transporters. Pflugers Arch. 2014 Jan;466(1):77-89
  8. Ramasamy U, Anwer MS, Schonhoff CM. 2013. Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake. Am J Physiol Gastrointest Liver Physiol. 2013 Oct 01;305(7):G513-9
  9. Pumphrey SA, Pizzirani S, Pirie CG, Anwer MS, Logvinenko T. 2013. Western blot patterns of serum autoantibodies against optic nerve antigens in dogs with goniodysgenesis-related glaucoma. Am J Vet Res. 2013 Apr;74(4):621-8
  10. Schonhoff CM, Webster CR, Anwer MS. 2013. Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cϵ in HUH-NTCP Cells. Hepatology. 2013 Jul;58(1):284-92
  11. Anwer MS, Hashim R, Khan FA, Ijaz A. 2012. Frequency of conversion to overt hypothyroidism in patients with and without subclinical hypothyroidism. J Ayub Med Coll Abbottabad. 2012 Jul-Dec;24(3-4):166-70
  12. Park SW, Schonhoff CM, Webster CR, Anwer MS. 2012. Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane. Am J Physiol Gastrointest Liver Physiol. 2012 Sep 01;303(5):G657-65
  13. Anwer MS. 2012. INTRACELLULAR SIGNALING BY BILE ACIDS. J Biosci (Rajshari). 2012;20:1-23
  14. Johnston A, Ponzetti K, Anwer MS, Webster CR. 2011. cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase. Am J Physiol Gastrointest Liver Physiol. 2011 Aug;301(2):G385-400
  15. Schonhoff CM, Ramasamy U, Anwer MS. 2011. Nitric oxide-mediated inhibition of taurocholate uptake involves S-nitrosylation of NTCP. Am J Physiol Gastrointest Liver Physiol. 2011 Feb;300(2):G364-70
  16. Hohenester S, Gates A, Wimmer R, Beuers U, Anwer MS, Rust C, Webster CR. 2010. Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells. J Hepatol. 2010 Nov;53(5):918-26
  17. Schonhoff CM, Webster CR, Anwer MS. 2010. Cyclic AMP stimulates Mrp2 translocation by activating p38{alpha} MAPK in hepatic cells. Am J Physiol Gastrointest Liver Physiol. 2010 May;298(5):G667-74
  18. Ponzetti K, King M, Gates A, Anwer MS, Webster CR. 2010. Cyclic AMP-guanine exchange factor activation inhibits JNK-dependent lipopolysaccharide-induced apoptosis in rat hepatocytes. Hepat Med. 2010 Jan;2010(2):1-11
  19. Schonhoff CM, Yamazaki A, Hohenester S, Webster CR, Bouscarel B, Anwer MS. 2009. PKC{epsilon}-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line. Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1259-67
  20. Gates A, Hohenester S, Anwer MS, Webster CR. 2009. cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 beta/alpha in rat hepatocytes. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G764-74
  21. Schonhoff CM, Thankey K, Webster CR, Wakabayashi Y, Wolkoff AW, Anwer MS. 2008. Rab4 facilitates cyclic adenosine monophosphate-stimulated bile acid uptake and Na+-taurocholate cotransporting polypeptide translocation. Hepatology. 2008 Nov;48(5):1665-70
  22. Schonhoff CM, Gillin H, Webster CR, Anwer MS. 2008. Protein kinase Cdelta mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. Hepatology. 2008 Apr;47(4):1309-16
  23. Sarkar S, Bananis E, Nath S, Anwer MS, Wolkoff AW, Murray JW. 2006. PKCzeta is required for microtubule-based motility of vesicles containing the ntcp transporter. Traffic. 2006 Aug;7(8):1078-91
  24. Anwer MS, Gillin H, Mukhopadhyay S, Balasubramaniyan N, Suchy FJ, Ananthanarayanan M. 2005. Dephosphorylation of Ser-226 facilitates plasma membrane retention of Ntcp. J Biol Chem. 2005 Sep 30;280(39):33687-92
  25. Cullen KA, McCool J, Anwer MS, Webster CR. 2004. Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis. Am J Physiol Gastrointest Liver Physiol. 2004 Aug;287(2):G334-43
  26. McConkey M, Gillin H, Webster CR, Anwer MS. 2004. Cross-talk between protein kinases Czeta and B in cyclic AMP-mediated sodium taurocholate co-transporting polypeptide translocation in hepatocytes. J Biol Chem. 2004 May 14;279(20):20882-8
  27. Anwer MS. 2004. Cellular regulation of hepatic bile acid transport in health and cholestasis. Hepatology. 2004 Mar;39(3):581-90
  28. Webster CR, Boria P, Usechak P, Anwer MS. 2002. S-adenosylmethionine and cAMP confer differential cytoprotection against bile acid-induced apoptosis in canine renal tubular cells and primary rat hepatocytes. Vet Ther. 2002;3(4):474-84
  29. Webster CR, Usechak P, Anwer MS. 2002. cAMP inhibits bile acid-induced apoptosis by blocking caspase activation and cytochrome c release. Am J Physiol Gastrointest Liver Physiol. 2002 Sep;283(3):G727-38
  30. Webster CR, Blanch C, Anwer MS. 2002. Role of PP2B in cAMP-induced dephosphorylation and translocation of NTCP. Am J Physiol Gastrointest Liver Physiol. 2002 Jul;283(1):G44-50
  31. Webster CR, Srinivasulu U, Ananthanarayanan M, Suchy FJ, Anwer MS. 2002. Protein kinase B/Akt mediates cAMP- and cell swelling-stimulated Na+/taurocholate cotransport and Ntcp translocation. J Biol Chem. 2002 Aug 09;277(32):28578-83
  32. Webster CR, Anwer MS. 2001. Phosphoinositide 3-kinase, but not mitogen-activated protein kinase, pathway is involved in hepatocyte growth factor-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes. Hepatology. 2001 Mar;33(3):608-15
  33. Webster CR, Blanch CJ, Phillips J, Anwer MS. 2000. Cell swelling-induced translocation of rat liver Na(+)/taurocholate cotransport polypeptide is mediated via the phosphoinositide 3-kinase signaling pathway. J Biol Chem. 2000 Sep 22;275(38):29754-60
  34. Webster CR, Anwer MS. 1999. Role of the PI3K/PKB signaling pathway in cAMP-mediated translocation of rat liver Ntcp. Am J Physiol. 1999 Dec;277(6 Pt 1):G1165-72
  35. Mukhopadhyay S, Ananthanarayanan M, Stieger B, Meier PJ, Suchy FJ, Anwer MS. 1998. Sodium taurocholate cotransporting polypeptide is a serine, threonine phosphoprotein and is dephosphorylated by cyclic adenosine monophosphate. Hepatology. 1998 Dec;28(6):1629-36
  36. Mukhopadhyay S, Webster CR, Anwer MS. 1998. Role of protein phosphatases in cyclic AMP-mediated stimulation of hepatic Na+/taurocholate cotransport. J Biol Chem. 1998 Nov 06;273(45):30039-45
  37. Webster CR, Anwer MS. 1998. Cyclic adenosine monophosphate-mediated protection against bile acid-induced apoptosis in cultured rat hepatocytes. Hepatology. 1998 May;27(5):1324-31
  38. Mukhopadhayay S, Ananthanarayanan M, Stieger B, Meier PJ, Suchy FJ, Anwer MS. 1997. cAMP increases liver Na+-taurocholate cotransport by translocating transporter to plasma membranes. Am J Physiol. 1997 Oct;273(4 Pt 1):G842-8
  39. Li F, Irie K, Anwer MS, Fisher M. 1997. Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model. J Cereb Blood Flow Metab. 1997 Oct;17(10):1132-5
  40. Anwer MS, Meyer DJ. 1995. Bile acids in the diagnosis, pathology, and therapy of hepatobiliary diseases. Vet Clin North Am Small Anim Pract. 1995 Mar;25(2):503-17
  41. Anwer MS. 1994. Mechanism of activation of the Na+/H+ exchanger by arginine vasopressin in hepatocytes. Hepatology. 1994 Nov;20(5):1309-17
  42. Grüne S, Engelking LR, Anwer MS. 1993. Role of intracellular calcium and protein kinases in the activation of hepatic Na+/taurocholate cotransport by cyclic AMP. J Biol Chem. 1993 Aug 25;268(24):17734-41
  43. Anwer MS. 1993. Mechanism of ionomycin-induced intracellular alkalinization of rat hepatocytes. Hepatology. 1993 Aug;18(2):433-9
  44. Anwer MS. 1993. Transhepatic solute transport and bile formation. Adv Vet Sci Comp Med. 1993;37:1-29
  45. Anwer MS, Berk PD, Suchy FJ, Wolkoff AW. 1992. Characterization of membrane transport mechanisms: a summary of the 1991 AASLD single topic conference. Hepatology. 1992 Jun;15(6):1179-93
  46. Anwer MS. 1992. What are the intracellular signals for agonist-activated calcium entry into hepatocytes? Hepatology. 1992 Jun;15(6):1205-7
  47. Anwer MS. 1992. Mechanism of bile acid-induced HCO3-(-)rich hypercholeresis. An analysis based on quantitative acid-base chemistry. J Hepatol. 1992 Jan;14(1):118-26
  48. Anwer MS, Atkinson JM. 1992. Intracellular calcium-mediated activation of hepatic Na+/H+ exchange by arginine vasopressin and phenylephrine. Hepatology. 1992 Jan;15(1):134-43
  49. Anwer MS, Branson AU, Atkinson JM. 1991. Mechanism of inhibition of hepatic bile acid uptake by amiloride and 4,4'-diisothiocyano-2,2'-disulfonic stilbene (DIDS). Biochem Pharmacol. 1991 Dec 11;42 Suppl:S135-41
  50. Zimniak P, Little JM, Radominska A, Oelberg DG, Anwer MS, Lester R. 1991. Taurine-conjugated bile acids act as Ca2+ ionophores. Biochemistry. 1991 Sep 03;30(35):8598-604
  51. Anwer MS. 1990. Mechanism of cholate uptake: Na(+)-cotransport, but not cholate/OH- exchange. Hepatology. 1990 Nov;12(5):1248-9
  52. Anwer MS, Atkinson JM, Zimniak P. 1990. Amiloride and taurine inhibit cholate-induced HCO3(-)-rich choleresis in perfused rat livers. Am J Physiol. 1990 Sep;259(3 Pt 1):G453-61
  53. Engelking LR, Anwer MS, McConnell J, Sullivan D, Shuster L. 1990. Cocaine and lidocaine interfere with epinephrine-induced changes in intracellular calcium concentration and glucose efflux from rat hepatocytes. Pharmacology. 1990;40(3):129-36
  54. Albert K, Sudmeier JL, Anwer MS, Bachovchin WW. 1989. Continuous-flow 13C-filtered 1H NMR spectroscopy of ethanol metabolism in rat liver perfusate. Magn Reson Med. 1989 Sep;11(3):309-15
  55. Anwer MS, Hondalus MK, Atkinson JM. 1989. Ursodeoxycholate-induced changes in hepatic Na+-H+ exchange and biliary HCO3- excretion. Am J Physiol. 1989 Sep;257(3 Pt 1):G371-9
  56. Garhart CA, Anwer MS, Shuster L. 1989. Cocaine-induced changes in perfusion pressure and bile flow in perfused rat livers. Biochem Pharmacol. 1989 Jul 01;38(13):2139-45
  57. Anwer MS, Little JM, Oelberg DG, Zimniak P, Lester R. 1989. Effect of bile acids on calcium efflux from isolated rat hepatocytes and perfused rat livers. Proc Soc Exp Biol Med. 1989 Jun;191(2):147-52
  58. Engelking LR, Anwer MS, Hofmann AF. 1989. Basal and bile salt-stimulated bile flow and biliary lipid excretion in ponies. Am J Vet Res. 1989 Apr;50(4):578-82
  59. Anwer MS, Nolan K, Hardison WG. 1988. Role of bicarbonate in biliary excretion of diisothiocyanostilbene disulfonate. Am J Physiol. 1988 Dec;255(6 Pt 1):G713-22
  60. Anwer MS, Engelking LR, Nolan K, Sullivan D, Zimniak P, Lester R. 1988. Hepatotoxic bile acids increase cytosolic Ca++ activity of isolated rat hepatocytes. Hepatology. 1988 Jul-Aug;8(4):887-91
  61. Montrose MH, Lester R, Zimniak P, Anwer MS, Murer H. 1988. Bile acids increase cellular free calcium in cultured kidney cells (LLC-PK). Pflugers Arch. 1988 Jul;412(1-2):164-71
  62. Anwer MS, Nolan K. 1988. Characterization of H+ efflux pathways in rat hepatocytes. Hepatology. 1988 Jul-Aug;8(4):728-34
  63. Court MH, Engelking LR, Dodman NH, Anwer MS, Seeler DC, Clark M. 1987. Pharmacokinetics of dantrolene sodium in horses. J Vet Pharmacol Ther. 1987 Sep;10(3):218-26
  64. Anwer MS. 1987. Effects of ion substitution on transport and choleretic effect of ouabain. Am J Physiol. 1987 Mar;252(3 Pt 1):G357-64
  65. Ogilvie GK, Engelking LR, Anwer MS. 1985. Effects of plasma sample storage on blood ammonia, bilirubin, and urea nitrogen concentrations: cats and horses. Am J Vet Res. 1985 Dec;46(12):2619-22
  66. Anwer MS, Clayton LM. 1985. Role of extracellular Ca2+ in hepatic bile formation and taurocholate transport. Am J Physiol. 1985 Dec;249(6 Pt 1):G711-8
  67. Engelking LR, Anwer MS, Lofstedt J. 1985. Hepatobiliary transport of indocyanine green and sulfobromophthalein in fed and fasted horses. Am J Vet Res. 1985 Nov;46(11):2278-84
  68. Anwer MS. 1985. Furosemide choleresis in isolated perfused rat liver: partial dependency on perfusate sodium and chloride. J Pharmacol Exp Ther. 1985 Nov;235(2):313-8
  69. Anwer MS, O'Maille ER, Hofmann AF, DiPietro RA, Michelotti E. 1985. Influence of side-chain charge on hepatic transport of bile acids and bile acid analogues. Am J Physiol. 1985 Oct;249(4 Pt 1):G479-88
  70. Anwer MS, Hegner D, Engelking LR. 1984. Essential role of sodium and chloride for theophylline-induced choleresis in the isolated perfused rat liver. Proc Soc Exp Biol Med. 1984 May;176(1):70-6
  71. Fiebiger I, Anwer MS, Hegner D. 1983. Therapeutic doses of erythromycin esteolate is not cholestatic in rats in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1983 May;322(4):295-7
  72. Anwer MS, Hegner D. 1983. Sodium and chloride dependency of dibucaine- and procaine-induced choleresis in isolated perfused rat livers. J Pharmacol Exp Ther. 1983 May;225(2):284-90
  73. Anwer MS, Hegner D. 1983. Role of inorganic electrolytes in bile acid-independent canalicular bile formation. Am J Physiol. 1983 Feb;244(2):G116-24
  74. Anwer MS, Hegner D. 1982. Importance of solvent drag and diffusion in bile acid-dependent bile formation: ion substitution studies in isolated perfused rat liver. Hepatology. 1982 Sep-Oct;2(5):580-6
  75. Anwer MS, Hegner D. 1982. Stereospecific reduction of 3- and 7-oxo groups of oxocholanic acids in isolated perfused rat liver. Hoppe Seylers Z Physiol Chem. 1982 Jul;363(7):731-5
  76. Brigelius R, Anwer MS. 1981. Increased biliary GSSG-secretion and loss of hepatic glutathione in isolated perfused rat liver after paraquat treatment. Res Commun Chem Pathol Pharmacol. 1981 Mar;31(3):493-502
  77. Kroker R, Hegner D, Anwer MS. 1980. Altered hepatobiliary transport of taurocholic acid in aged rats. Mech Ageing Dev. 1980 Apr;12(4):367-73
  78. Engelking LR, Gronwall R, Anwer MS. 1980. Effect of dehydrocholic, chenodeoxycholic, and taurocholic acids on the excretion of bilirubin. Am J Vet Res. 1980 Mar;41(3):355-61
  79. Anwer MS, Hegner D. 1979. An enzymatic method for the quantitative determination of 3-keto bile acids. Anal Biochem. 1979 Nov 01;99(2):408-14
  80. Anwer MS, Hegner D. 1979. Study of cholic acid conjugation by isolated rat hepatocytes. Hoppe Seylers Z Physiol Chem. 1979 Apr;360(4):515-22
  81. Hegner D, Kroker R, Anwer MS. 1979. [The influence of clanobutin on bile secretion in the isolated perfused rat liver (author's transl)]. Arzneimittelforschung. 1979;29(1):11-5
  82. Anwer MS, Hegner D. 1978. Effect of organic anions on bile acid uptake by isolated rat hepatocytes. Hoppe Seylers Z Physiol Chem. 1978 Aug;359(8):1027-30
  83. Kroker R, Anwer MS, Hegner D. 1978. A compartmental model for hepatic transport of taurocholic acid in isolated perfused rat liver. Naunyn Schmiedebergs Arch Pharmacol. 1978 Jul;303(3):287-93
  84. Kroker R, Anwer MS, Hegner D. 1978. The lack of active bile acid transport in AS-30 D ascites hepatoma cells. Naunyn Schmiedebergs Arch Pharmacol. 1978 Jul;303(3):299-301
  85. Anwer MS, Hegner D. 1978. Interaction of fusidates with bile acid uptake by isolated rat hepatocytes. Naunyn Schmiedebergs Arch Pharmacol. 1978 May;302(3):329-32
  86. Kroker R, Anwer MS, Hegner D. 1978. The interaction of rifamycin SV with hepatic transport of taurocholic acid in the isolated perfused rat liver. Naunyn Schmiedebergs Arch Pharmacol. 1978 May;302(3):323-7
  87. Anwer MS, Kroker R, Hegner D. 1978. Inhibition of hepatic uptake of bile acids by rifamycins. Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar;302(1):19-24
  88. Anwer MS, Hegner D. 1978. Effect of Na on bile acid uptake by isolated rat hepatocytes. Evidence for a heterogeneous system. Hoppe Seylers Z Physiol Chem. 1978 Feb;359(2):181-92
  89. Kroker R, Anwer MS, Hegner D. 1977. Characterization of methylumbilliferone (mendiaxon r)-induced choleresis in the isolated perfused rat liver. Acta Hepatogastroenterol (Stuttg). 1977 Oct;24(5):348-54
  90. Kroker R, Anwer MS, Hegner D. 1977. The age dependence of bile acid metabolism in rats. Aktuelle Gerontol. 1977 Oct;7(10):539-45
  91. Anwer MS, Kroker R, Hegner D, Petter A. 1977. Cholic acid binding to isolated rat liver plasma membranes. Hoppe Seylers Z Physiol Chem. 1977 May;358(5):543-53
  92. Kroker R, Anwer MS, Hegner D. 1977. Effect of sporidesmin on bile acid metabolism in isolated rat hepatocytes. Zentralbl Veterinarmed A. 1977 Mar;24(3):205-9
  93. Anwer MS, Kroker R, Hegner D. 1976. Effect of albumin on bile acid uptake by isolated rat hepatocytes. Is there a common bile acid carrier? Biochem Biophys Res Commun. 1976 Nov 08;73(1):63-71
  94. Anwer MS, Kroker R, Hegner D. 1976. Cholic acid uptake and isolated rat hepatocytes. Hoppe Seylers Z Physiol Chem. 1976 Nov;357(11):1477-86
  95. Anwer MS, Gronwall R. 1976. A compartmental model for bilirubin kinetics in isolated perfused rat liver. Can J Physiol Pharmacol. 1976 Jun;54(3):277-86
  96. Hegner D, Petter A, Kroker R, Anwer MS, Scharmann W, Breuninger V. 1976. Leucocidin from Pseudomonas aeruginosa and membrane functions. Naunyn Schmiedebergs Arch Pharmacol. 1976;293(1):49-55
  97. Anwer MS, Engelking LR, Gronwall R, Klentz RD. 1976. Plasma bile acid elevation following CCI4 induced liver damage in dogs, sheep, calves and ponies. Res Vet Sci. 1976 Mar;20(2):127-30
  98. Anwer MS, Chapman TE, Gronwall R. 1976. Glucose utilization and recycling in ponies. Am J Physiol. 1976 Jan;230(1):138-42
  99. Engelking LR, Gronwall R, Anwer MS. 1976. Effect of bile acid on hepatic excretion and storage of bilirubin in ponies. Am J Vet Res. 1976 Jan;37(1):47-50
  100. Anwer MS, Gronwall RR, Engelking LR, Klentz RD. 1975. Bile acid kinetics and bile secretion in the pony. Am J Physiol. 1975 Sep;229(3):592-7

General Research Interests

Functional abnormalities associated with various liver diseases lead to accumulation of toxic products (such as bilirubin in jaundice and bile acids) in blood and premature death of liver cells. One of the major determinants is the inability of the liver to properly regulate bile acid transport from blood to bile. Studies are conducted to better understand the mechanisms regulating bile acid transport. Specifically, studies are designed to determine the role of various kinases and phosphatases in the regulation of bile acid transport using primary hepatocytes, hepatic cell lines and transgenic mice. Techniques used are cell culture, transfection of cell lines, solute uptake, western blots, protein phosphorylation, Protein S-nitrosylation, etc.

Selected Research Projects

  • Role of protein kinase Cs in the regulation of hepatic transporters.
  • Mechanism of taurolithocholate-induced cholestasis.
  • Role of protein S-nitrosylation in sepsis-induced cholestasis.
  • Mechanisms of anticholestatic effects of cAMP and tauroursodeoxycholate.

Research and Clinical Interests

  • Hepatic diseases
  • Pharmacokinetics

Research Interests by Area

Hepatic Diseases
  • Mechanism of bile formation and cholestasis
Training Grants
  • NIH Short term research training for DVM students

Major Specialized Equipment

  • Fluorescent spectrophotometers
  • UV-VIS spectrophotometers
  • Scintillation Counter
  • Gel-Electrophoresis (1D & 2D) apparatus
  • Film developer
  • Cell culture facility
  • Fluroescence microscope

Lab Personnel

  • Holly Jameson, Sr. Research Coordinator
  • Ariel Hobson, Research Technician
  • Umadevi Ramasamy, Research Technician
  • Sewon Park, Graduate Student
  • Christopher Schonhoff, Ph.D., Research Assistant Professor