Cummings School of Veterinary Medicine at Tufts University
Melissa Mazan

Associate Professor

Internal Medicine, Equine Respiratory System, Lung Function
Director of Equine Sports Medicine Program

Campus Phone:
508-839-5395 x84545

Fax:
508-839-7922

Education

  • DVM - Tufts University School of Veterinary Medicine - 1993
  • BA - Yale University - 1983

Board Certification

  • American College of Veterinary Internal Medicine

Age effects on blood gas, spirometry, airway reactivity, and bronchoalveolar lavage fluid cytology in clinically healthy horses

Author(s):Pacheco, A.P. | Paradis, M.R. | Hoffman, A.M. | Hermida, P. | Sanchez, A. | Nadeau, J.A. | Tufts, M. | Mazan, M.R.
Publication year: 2014
Journal / Book title: Journal of Veterinary Internal Medicine

Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol

Author(s):Mazan, M.R. | Lascola, K. | Bruns, S.J. | Hoffman, A.M.
Publication year: 2014
Journal / Book title: Canadian Journal of Veterinary Research

Endogenous distal airway progenitor cells, lung mechanics, and disproportionate lobar growth following long-term postpneumonectomy in mice

Author(s):Eisenhauer, P. | Earle, B. | Loi, R. | Sueblinvong, V. | Goodwin, M. | Allen, G.B. | Lundblad, L. | Mazan, M.R. | Hoffman, A.M. | Weiss, D.J.
Publication year: 2013
Journal / Book title: Stem Cells

Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema

Author(s):Ingenito, E.P. | Tsai, L. | Murthy, S. | Tyagi, S. | Mazan, M. | Hoffman, A.
Publication year: 2012
Journal / Book title: Cell Transplantation

Respiratory mechanics and results of cytologic examination of bronchoalveolar lavage fluid in healthy adult alpacas

Author(s):Pacheco, A.P. | Bedenice, D. | Mazan, M.R. | Hoffman, A.M.
Publication year: 2012
Journal / Book title: American Journal of Veterinary Research

Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung

Author(s):Hoffman, A.M. | Paxson, J.A. | Mazan, M.R. | Davis, A.M. | Tyagi, S. | Murthy, S. | Ingenito, E.P.
Publication year: 2011
Journal / Book title: Stem Cells and Development

Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myofibroblastic differentiation

Author(s):Paxson, J.A. | Gruntman, A. | Parkin, C.D. | Mazan, M.R. | Davis, A. | Ingenito, E.P. | Hoffman, A.M.
Publication year: 2011
Journal / Book title: PLoS ONE

Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice

Author(s):Hoffman, A.M. | Shifren, A. | Mazan, M.R. | Gruntman, A.M. | Lascola, K.M. | Nolen-Walston, R.D. | Kim, C.F. | Tsai, L. | Pierce, R.A. | Mecham, R.P. | Ingenito, E.P.
Publication year: 2010
Journal / Book title: American Journal of Physiology - Lung Cellular and Molecular Physiology

Global gene expression patterns in the post-pneumonectomy lung of adult mice

Author(s):Paxson, J.A. | Parkin, C.D. | Iyer, L.K. | Mazan, M.R. | Ingenito, E.P. | Hoffman, A.M.
Publication year: 2009
Journal / Book title: Respiratory Research

Perspectives in professional education a description of the tufts cummings school of veterinary medicine-Massachusetts equine clinic combined equine medicine internship program

Author(s):Mazan, M.R. | Merriam, J.
Publication year: 2009
Journal / Book title: Journal of the American Veterinary Medical Association

A description of the Tufts Cummings School of Veterinary Medicine-Massachusetts Equine Clinic combined equine medicine internship program.

Author(s):Mazan, M.R. | Merriam, J.
Publication year: 2009
Journal / Book title: Journal of the American Veterinary Medical Association

Questionnaire assessment of airway disease symptoms in equine barn personnel

Author(s):Mazan, M.R. | Svatek, J. | Maranda, L. | Christiani, D. | Ghio, A. | Nadeau, J. | Hoffman, A.M.
Publication year: 2009
Journal / Book title: Occupational Medicine

Reproducibility of airway responsiveness in horses using flowmetric plethysmography and histamine bronchoprovocation

Author(s):Nolen-Walston, R.D. | Kuehn, H. | Boston, R.C. | Mazan, M.R. | Wilkins, P.A. | Bruns, S. | Hoffman, A.M.
Publication year: 2009
Journal / Book title: Journal of Veterinary Internal Medicine

Association between cough and cytology of bronchoalveolar lavage fluid and pulmonary function in horses diagnosed with inflammatory airway disease

Author(s):Bedenice, D. | Mazan, M.R. | Hoffman, A.M.
Publication year: 2008
Journal / Book title: Journal of Veterinary Internal Medicine

Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration

Author(s):Nolen-Walston, R.D. | Kim, C.F. | Mazan, M.R. | Ingenito, E.P. | Gruntman, A.M. | Tsai, L. | Boston, R. | Woolfenden, A.E. | Jacks, T. | Hoffman, A.M.
Publication year: 2008
Journal / Book title: American Journal of Physiology - Lung Cellular and Molecular Physiology

Bronchoscopic measurement of collateral ventilation in a sheep model of emphysema

Author(s):Tsai, L.W. | Hoffman, A.M. | Mazan, M.R. | Ingenito, E.P.
Publication year: 2007
Journal / Book title: Respiration

Respiratory mechanics in sedated and nonsedated adult llamas

Author(s):Lascola, K.M. | Hoffman, A.M. | Mazan, M.R. | Bedenice, D.
Publication year: 2007
Journal / Book title: American Journal of Veterinary Research

Plethysmographic comparison of breathing pattern in heaves (recurrent airway obstruction) versus experimental bronchoconstriction or hyperpnea in horses

Author(s):Hoffman, A.M. | Oura, T.J. | Riedelberger, K.J. | Mazan, M.R.
Publication year: 2007
Journal / Book title: Journal of Veterinary Internal Medicine

Noninfectious Respiratory Problems

Author(s):Mazan, M.R. | Paradis, M.R.
Publication year: 2006
Journal / Book title: Equine Neonatal Medicine

Restrained whole body plethysmography for measure of strain-specific and allergen-induced airway responsiveness in conscious mice

Author(s):Lofgren, J.L.S. | Mazan, M.R. | Ingenito, E.P. | Lascola, K. | Seavey, M. | Walsh, A. | Hoffman, A.M.
Publication year: 2006
Journal / Book title: Journal of Applied Physiology

General Research Interests

  • The equine respiratory system: Pathophysiology of small airway inflammatory disease - airway smooth muscle
  • Effects of particulate matter air pollution on equine respiratory disease
  • Resting energy in horses with recurrent airway obstruction
  • Non-invasive lung function testing
  • Stem cell applications in equine internal medicine
  • Role of the trophic macrophage in lung regeneration

Teaching

  • Director of TCSVM/Massachusetts Equine Clinic Large Animal Medicine Internship
  • Equine sports medicine, equine exercise physiology, respiratory pathophysiology

Research Interests by Area

Regenerative Medicine
  • Stem cell applications for respiratory disease and systemic inflammation.
Spontaneous Animal Disease Models
  • Airway disease in horses, COPD, regenerative medicine

Research Interests by Organ System and Disease

Respiratory Diseases
  • Dynamics of bronchioalveolar stem cell response to sublethal hyperoxia and recovery in mice. Respiratory: Role of the macrophage; environmental respiratory disease (animal models); stem cell applications