Cummings School of Veterinary Medicine at Tufts University
Melissa Mazan

Associate Professor

Internal Medicine, Equine Respiratory System, Lung Function
Director of Equine Sports Medicine Program

Campus Phone:
508-839-5395 x84545

Fax:
508-839-7922

Education

  • DVM - Tufts University School of Veterinary Medicine - 1993
  • BA - Yale University - 1983

Board Certification

  • American College of Veterinary Internal Medicine
  1. Pacheco A, Bedenice D, Mazan M, Hoffman AM. Respiratory mechanics and results of cytologic examination of bronchoalveolar lavage fluid in healthy adult alpacas. Am J Vet Res 2012; Jan;73:146-152.
  2. Ingenito EP, Tsai L, Murthy S, Tyagi S, Mazan M, Hoffman A. Autologious lung-derived mesenchymal stem cell transplantation in experimental emphysema. Cell Transplant. 2012:21(1):175-189.
  3. Paxson JA, Gruntman A, Parkin CD, Mazan MR, Davis A, Ingenito EP, Hoffman AM. Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myfibroblastic differentiation. PLoS One 2011:6(8):e23232.
  4. Hoffman AM, Paxson JA, Mazan MR, Davis AM, Tyagi S, Murthy S, Ingenito EP. Lung derived mesenchymal stromal cell post-transplantaion survival, persistence, paracrine expression, and repair of elastase injured lung. Stem Cells Dev 2011;Oct:20(10)1779-1792.
  5. Hoffman AM, Shifren A, Mazan MR, Gruntman AM, LAscola K, Nolen-Walston R, Kim CF, Tsai L, Pierce RA, Mecham R, and Ingenito EP. Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice. Am J Physiol: Lung Cell Mol Physiol 2010;298:L158-168. PMID 19915155.
  6. Paxson J, Parkin C, Iyer L, Mazan MR, Ingenito EP, and Hoffman AM. Global gene expression patterns during post-pneumonectomy lung regeneration in adult mice. Resp Res 2009:10:92. PMID 19804646.
  7. Nolen-Walston RD, Kuehn H, Boston RC, Mazan MR, Wilkins PA, Bruns S, Hoffman AM. Reproducibility of airway responsiveness in horses using flowmetric plethysmography and histamine bronchoprovocation. J Vet Intern Med 2009;23:631-635.
  8. Mazan MR, Merriam JG. Perspectives in Professional Education "A Description of the Tufts Cummings School of Veterinary Medicine" Massachusetts Equine Clinic Combined Equine Medicine Internship Program. JAVMA 2009, 235: 38-40.
  9. Mazan MR, Svatek J, Maranda L, Christiani D, Ghio A, Nadeau J, Hoffman AM. Questionnaire assessment of airway disease symptoms in equine barn personnel. Occup Med 2009;59(4):220-225.
  10. Ceresia ML, Fasser CE, Rush JE, Scheife RT, Orcutt CJ, Michalski DL,Mazan MR, Dorsey MT, Bernardi SP. The role and education of the veterinary pharmacist. Am J Pharm Educ. 2009;19:73:16.
  11. Nolen-Walston RD, Boston RC, Wilkins PA, Mazan MR, Kuehn H, Hoffman AM. Reproducibility of airway responsiveness using flowmetric plethysmography and histamine bronchoprovocation in horses. J Vet Int Med 2009:23;631-635.

General Research Interests

  • The equine respiratory system: Pathophysiology of small airway inflammatory disease - airway smooth muscle
  • Effects of particulate matter air pollution on equine respiratory disease
  • Resting energy in horses with recurrent airway obstruction
  • Non-invasive lung function testing
  • Stem cell applications in equine internal medicine
  • Role of the trophic macrophage in lung regeneration

Teaching

  • Director of TCSVM/Massachusetts Equine Clinic Large Animal Medicine Internship
  • Equine sports medicine, equine exercise physiology, respiratory pathophysiology

Research Interests by Area

Regenerative Medicine
  • Stem cell applications for respiratory disease and systemic inflammation.
Spontaneous Animal Disease Models
  • Airway disease in horses, COPD, regenerative medicine

Research Interests by Organ System and Disease

Respiratory Diseases
  • Dynamics of bronchioalveolar stem cell response to sublethal hyperoxia and recovery in mice. Respiratory: Role of the macrophage; environmental respiratory disease (animal models); stem cell applications