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Melissa Mazan - DVM, DACVIM

Melissa Mazan
Internal Medicine, Equine Respiratory System, Lung Function

Campus Phone:
508-839-5395 x84545



  • DVM - Tufts University School of Veterinary Medicine - 1993
  • BA - Yale University - 1983

Board Certification

  • American College of Veterinary Internal Medicine
  1. Mazan, M.R. 2018. Lower Airway Disease in the Athletic Horse. Veterinary Clinics of North America - Equine Practice.
  2. Mazan, M.R., Kay, G., Souhail, M.L., Bubeck, K., Jenei, T., Merriam, J. 2017. Patients without borders: Using telehealth to provide an international experience in veterinary global health for veterinary students. Journal of Veterinary Medical Education.
  3. Viner, M., Mazan, M., Bedenice, D., Mapes, S., Pusterla, N. 2017. Comparison of Serum Amyloid A in Horses With Infectious and Noninfectious Respiratory Diseases. Journal of Equine Veterinary Science.
  4. Houtsma, A., Bedenice, D., Pusterla, N., Pugliese, B., Mapes, S., Hoffman, A.M., Paxson, J., Rozanski, E., Mukherjee, J., Wigley, M., Mazan, M.R. 2015. Association between inflammatory airway disease of horses and exposure to respiratory viruses: A case control study. Multidisciplinary Respiratory Medicine.
  5. Mazan, M.R. 2015. Update on noninfectious inflammatory diseases of the lower airway. Veterinary Clinics of North America - Equine Practice.
  6. Restifo, M.M., Bedenice, D., Thane, K.E., Mazan, M.R. 2015. Cavitary Effusion Associated with Anaplasma phagocytophilum Infection in 2 Equids. Journal of Veterinary Internal Medicine.
  7. Bellas, E., Rollins, A., Moreau, J.E., Lo, T., Quinn, K.P., Fourligas, N., Georgakoudi, I., Leisk, G.G., Mazan, M., Thane, K.E., Taeymans, O., Hoffman, A.M., Kaplan, D.L., Kirker-Head, C.A. 2015. Equine model for soft-tissue regeneration. Journal of Biomedical Materials Research - Part B Applied Biomaterials.
  8. Mazan, M.R., Ceresia, M.L. 2014. Clinical pharmacology of the respiratory system. Equine Pharmacology.
  9. Pacheco, A.P., Paradis, M.R., Hoffman, A.M., Hermida, P., Sanchez, A., Nadeau, J.A., Tufts, M., Mazan, M.R. 2014. Age effects on blood gas, spirometry, airway reactivity, and bronchoalveolar lavage fluid cytology in clinically healthy horses. Journal of Veterinary Internal Medicine.
  10. Mazan, M.R., Lascola, K., Bruns, S.J., Hoffman, A.M. 2014. Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol. Canadian Journal of Veterinary Research.
  11. Eisenhauer, P., Earle, B., Loi, R., Sueblinvong, V., Goodwin, M., Allen, G.B., Lundblad, L., Mazan, M.R., Hoffman, A.M., Weiss, D.J. 2013. Endogenous distal airway progenitor cells, lung mechanics, and disproportionate lobar growth following long-term postpneumonectomy in mice. Stem Cells.
  12. Ingenito, E.P., Tsai, L., Murthy, S., Tyagi, S., Mazan, M., Hoffman, A. 2012. Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema. Cell Transplantation.
  13. Pacheco, A.P., Bedenice, D., Mazan, M.R., Hoffman, A.M. 2012. Respiratory mechanics and results of cytologic examination of bronchoalveolar lavage fluid in healthy adult alpacas. American Journal of Veterinary Research.
  14. Hoffman, A.M., Paxson, J.A., Mazan, M.R., Davis, A.M., Tyagi, S., Murthy, S., Ingenito, E.P. 2011. Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung. Stem Cells and Development.
  15. Paxson, J.A., Gruntman, A., Parkin, C.D., Mazan, M.R., Davis, A., Ingenito, E.P., Hoffman, A.M. 2011. Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myofibroblastic differentiation. PLoS ONE.
  16. Mazan, M.R. 2011. Inflammatory airway disease. Clinical Veterinary Advisor: The Horse.
  17. Mazan, M.R. 2011. Abnormal breathing. Clinical Veterinary Advisor: The Horse.
  18. Mazan, M.R., Tizard, I. 2011. Airway obstruction, recurrent. Clinical Veterinary Advisor: The Horse.
  19. Hoffman, A.M., Shifren, A., Mazan, M.R., Gruntman, A.M., Lascola, K.M., Nolen-Walston, R.D., Kim, C.F., Tsai, L., Pierce, R.A., Mecham, R.P., Ingenito, E.P. 2010. Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice. American Journal of Physiology - Lung Cellular and Molecular Physiology.
  20. Paxson, J.A., Parkin, C.D., Iyer, L.K., Mazan, M.R., Ingenito, E.P., Hoffman, A.M. 2009. Global gene expression patterns in the post-pneumonectomy lung of adult mice. Respiratory Research.

General Research Interests

  • The equine respiratory system: Pathophysiology of small airway inflammatory disease - airway smooth muscle
  • Effects of particulate matter air pollution on equine respiratory disease
  • Resting energy in horses with recurrent airway obstruction
  • Non-invasive lung function testing
  • Stem cell applications in equine internal medicine
  • Role of the trophic macrophage in lung regeneration


  • Director of TCSVM/Massachusetts Equine Clinic Large Animal Medicine Internship
  • Equine sports medicine, equine exercise physiology, respiratory pathophysiology

Research Interests by Area

Regenerative Medicine
  • Stem cell applications for respiratory disease and systemic inflammation.
Spontaneous Animal Disease Models
  • Airway disease in horses, COPD, regenerative medicine

Research Interests by Organ System and Disease

Respiratory Diseases
  • Dynamics of bronchioalveolar stem cell response to sublethal hyperoxia and recovery in mice. Respiratory: Role of the macrophage; environmental respiratory disease (animal models); stem cell applications