Jennifer A Steele - DVM, PhD

Jennifer A Steele
Research Assistant Professor
Infectious disease, zoonoses, international health

Campus Phone:
508-887-4962
x84962

Dr. Jennifer Steele, Research Assistant Professor at the Cummings School of Veterinary Medicine at Tufts University. Dr. Steele is a veterinarian with training in infectious disease research.  She works on the research program on Clostridium difficile at the Cummings School, focusing on aspects of the disease pathology and immunology as well as development of new treatment strategies.  She has worked on the USAID funded RESPOND project in Southeast Asia and Africa, spending time working with universities in Thailand, Vietnam, Indonesia, Malaysia, and Laos in Asia and in Uganda, Rwanda, and the Democratic Republic of the Congo in Africa.  This international program focuses on activities and training that increase capacity of partner universities to respond to emergence of zoonotic diseases.  Her primary research interests are zoonotic diseases and international health. 

Education

  • PhD - Tufts University, 2011
  • DVM - University of Illinois, 2005
  • BS - University of Illinois, 2003

Intensified food production and correlated risks to human health in the Greater Mekong Subregion: A systematic review

Author(s):Richter, C.H. | Custer, B. | Steele, J.A. | Wilcox, B.A. | Xu, J.
Publication year: 2015
Journal / Book title: Environmental Health: A Global

Toward Operational Criteria for Ecosystem Approaches to Health

Author(s):Richter, C.H. | Steele, J.A. | Nguyen-Viet, H. | Xu, J. | Wilcox, B.A.
Publication year: 2015
Journal / Book title: EcoHealth

Hyperimmune bovine colostrum as a novel therapy to combat clostridium difficile infection

Author(s):Sponseller, J.K. | Steele, J.A. | Schmidt, D.J. | Kim, H.B. | Beamer, G. | Sun, X. | Tzipori, S.
Publication year: 2015
Journal / Book title: Journal of Infectious Diseases

Systemically administered IgG anti-toxin antibodies protect the colonic mucosa during infection with Clostridium difficilein the piglet model

Author(s):Cohen, O.R. | Steele, J.A. | Zhang, Q. | Schmidt, D.J. | Wang, Y. | Hamel, P.E.S. | Beamer, G. | Xu, B. | Tzipori, S.
Publication year: 2014
Journal / Book title: PLoS ONE

The roles of toxin A and toxin B in Clostridium difficile infection: Insights from the gnotobiotic piglet model

Author(s):Steele, J. | Parry, N. | Tzipori, S.
Publication year: 2013
Journal / Book title: Gut Microbes

MBX-500 Is effective for treatment of clostridium difficile infection in gnotobiotic piglets

Author(s):Steele, J. | Zhang, Q. | Beamer, G. | Butler, M. | Bowlin, T. | Tzipori, S.
Publication year: 2013
Journal / Book title: Antimicrobial Agents and Chemotherapy

Hyperimmune bovine colostrum for treatment of GI infections: A review and update on clostridium difficile

Author(s):Steele, J. | Sponseller, J. | Schmidt, D. | Cohen, O. | Tzipori, S.
Publication year: 2013
Journal / Book title: Human Vaccines and Immunotherapeutics

Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic clostridium difficile disease

Author(s):Steele, J. | Mukherjee, J. | Parry, N. | Tzipori, S.
Publication year: 2013
Journal / Book title: Journal of Infectious Diseases

Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models

Author(s):Steele, J. | Chen, K. | Sun, X. | Zhang, Y. | Wang, H. | Tzipori, S. | Feng, H.
Publication year: 2012
Journal / Book title: Journal of Infectious Diseases

Piglet models of acute or chronic Clostridium difficile illness

Author(s):Steele, J. | Feng, H. | Parry, N. | Tzipori, S.
Publication year: 2010
Journal / Book title: Journal of Infectious Diseases

An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins

Author(s):He, X. | Wang, J. | Steele, J. | Sun, X. | Nie, W. | Tzipori, S. | Feng, H.
Publication year: 2009
Journal / Book title: Journal of Microbiological Methods

General Research Interests

  • Clostridium difficile

Selected Research Projects

  • A gnotobiotic piglet model of Clostridium difficile infection
  • The relative roles of Toxin A and Toxin B in Clostridium difficile infection

Teaching

  • Masters in Conservation Medicine: Research Skills I – Systematic Review and Analysis
  • DVM – Epidemiology & Biostatistics
  • DVM – Immunology conferences
  • DVM – Histopathology laboratory
  • DVM – Problem based learning

Major Specialized Equipment

  • Steele J, Mukherjee J, Parry N, Tzipori S. Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic Clostridium difficile disease. J Infect Dis 2013; 207:323-30.
  • Steele J, Sponseller J, Schmidt D, Cohen O, Tzipori S. Hyperimmune bovine colostrum for treatment of GI infections: A review and update on Clostridium difficile. Human vaccines & immunotherapeutics 2013; 9.
  • Steele J, Chen K, Sun X, Zhang Y, Wang H, Tzipori S, Feng H. Systemic dissemination of Clostridium difficile toxins A and B is associated with severe, fatal disease in animal models.  Journal of Infectious Diseases 2012, 205(3):384-91.
  • Steele J, Mukherjee J, Parry N, Tzipori S. Antibody against TcdB, but not TcdA, prevents development of gastrointestinal and systemic Clostridium difficile disease.  Journal of Infectious Diseases 2012. In press.
  • Steele J, Feng H, Parry N, Tzipori S. Piglet models of acute or chronic Clostridium difficile illness. Journal of Infectious Diseases 2010, 201:428-434.
  • He X, Wang J, Steele J, Sun X, Nie W, Tzipori S, et al. An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins. Journal of Microbiological Methods 2009, 78:97-100.