Dr. Greice Krautz-Peterson is a Research Assistant Professor who received her PhD in Biochemistry and Immunology at Federal University of Minas Gerais, Brazil. During her PhD, in collaborative work at Northwestern University Medical School, Chicago, IL, she identified and expressed Trypanosoma cruzi antigens for evaluating effective treatment of patients with Chagas' disease. In 2004 and 2005, she worked with the research group on diarrheagenic E. coli/HUS associated diseases at the Cummings School of Veterinary Medicine and identified a new intracellular mechanism of shiga toxin neutralization by a human monoclonal antibody; she also characterized antibiotics that increase or inhibit toxin production. Greice joined the Molecular Helminthology lab in 2006 to study the function of enzymes and tegument transporters in the human parasite Schistosoma mansoni, using RNAi. She also worked as a co-investigator to test the capability of Clostridium difficile toxins to efficiently deliver an intracellular therapeutic agent that revert botulinum neurointoxication. Currently, Dr. Krautz-Peterson is the principal investigator of an NIH grant to study the gene function of molecules expressed on the schistosome surface that are likely to protect the parasite against the host’s immune attack. She is also testing fluorescence in vivo imaging as a new technology to study the pathogenesis of E. coli shiga toxins.
- PhD - Federal University of Minas Gerais, MG, Brazil - 1997
- MSc - Federal University of Minas Gerais, MG, Brazil - 1993
- BSc - Federal University of Minas Gerais, MG, Brazil - 1988
- Da'dara A, Krautz-Peterson G, Faghiri Z, Skelly PJ. 2012. Metabolite movement across the schistosome surface. J Helminthol. Feb 27:1-7.
- Krautz-Peterson G, Zhang Y, Chen K, Oyler GA, Feng H, Shoemaker CB. 2012. Retargeting Clostridium difficile toxin B to neuronal cells as a potential vehicle for cytosolic delivery of therapeutic biomolecules to treat botulism. J Toxicol.:760142.
- Bhardwaj R, Krautz-Peterson G, Da'dara A, Tzipori S, Skelly PJ. 2011. Tegumental phosphosdiesterase SmNPP-5 is a virulence factor for schistosomes. Infect Immun. Oct; 79(10):4276-84.
- Bhardwaj R, Krautz-Peterson G, Skelly PJ. Using RNA Interference in Schistosoma mansoni. 2011. Methods Mol Biol.; 764:223-39.
- Krautz-Peterson G, Simoes M, Faghiri Z, Ndegwa D, Oliveira G, Shoemaker CB, Skelly PJ. 2010. Suppressing glucose transporter gene expression in schistosomes impairs parasite feeding and decreases survival in the mammalian host. PLoS Pathog.; 3:6(6).
- Krautz-Peterson, G., Bhardwaj R, Faghiri Z, Tararam CA, Skelly PJ. 2009. RNA interference in schistosomes: machinery and methodology. Parasitol.; 21:1-11.
- Krautz-Peterson G, Ndegwa D, Vasquez K., Korideck H, Zhang J., Peterson JD, Skelly PJ. 2009. Imaging schistosomes in vivo. FASEB J.; 23: 2673-80.
- Zhang Q, Donohue-Rolfe A., Krautz-Peterson G, Sevo M, Parry N, Abeijon C, Tzipori S. 2009. Gnotobiotic piglet infection model for evaluating the safe use of antibiotics againstEscherichia coli O157:H7 infection. J Infect Dis.; 199:1-8.
- Krautz-Peterson G, Skelly PJ. 2008. Schistosome asparaginyl endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo. Mol Biochem Parasitol.; 159(1): 54-8.
- Krautz-Peterson G, Skelly PJ. 2008. Schistosoma mansoni:The Dicer gene and its Expression. Exp Parasitol.; 118(1):122-8.
- Krautz-Peterson G, Chapman-Bonofiglio S, Boisvert K, Feng H, Herman IM, Tzipori S. Sheoran AS. 2008. Intracellular neutralization of Shiga toxin 2 by an A subunit-specific human monoclonal. Infect Immun.; 76(5):1931-9.
- Krautz-Peterson G, Radwanska M, Ndegwa D, Shoemaker CB, Skelly PJ. 2007. Optimizing gene suppression in schistosomes using RNA interference. Mol Biochem Parasitol.;153(2):194-202.
- Krautz-Peterson G, Camargo S, Verrey F, Shoemaker CB, Skelly PJ. 2007. Amino Acid Transport in Schistosomes: Characterization of the Permease Heavy Chain SPRM1hc. J Biol Chem.; 282(30):21767-75.
General Research Interests
- Explore new tools for pathology and treatment evaluation of bacterial toxin diseases and infectious agents.
- Parasite molecular biology and immunology.
Selected Research Projects
- Study the mechanism of interaction of the parasitic helminth schistosome with the host complement system.
- Identify and validate biomarkers for live animal fluorescent imaging of shiga toxins from diarrheagenic E. coli/HUS associated diseases.