Elizabeth McNiel

Elizabeth McNiel
Assistant Professor

Campus Phone:
617-636-4715

Fax:
617-636-6205

Education

  • PhD (Radiation Biology) - Colorado State University - 2000
  • DVM - Texas A&M University - 1992
  • BS - University of Texas - Austin - 1988

Board Certification

  • ACVIM - Oncology
  • ACVR - Radiation Oncology
  1. Decker, B., Parker, H.G., Dhawan, D., Kwon, E.M., Karlins, E., Davis, B.W., Ramos-Vara, J.A., Bonney, P.L., McNiel, E.A., Knapp, D.W., Ostrander, E.A. 2015. Homologous mutation to human BRAF V600E is common in naturally occurring canine bladder cancer-evidence for a relevant model system and urine-based diagnostic test. Molecular Cancer Research.
  2. Kottakis, F., Foltopoulou, P., Sanidas, I., Keller, P., Wronski, A., Dake, B.T., Ezell, S.A., Shen, Z., Naber, S.P., Hinds, P.W., McNiel, E., Kuperwasser, C., Tsichlis, P.N. 2014. NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells. Cancer Research.
  3. Sacornrattana, O., Dervisis, N.G., Mcniel, E.A. 2013. Abdominal ultrasonographic findings at diagnosis of osteosarcoma in dogs and association with treatment outcome. Veterinary and Comparative Oncology.
  4. Ballegeer, E.A., Madrill, N.J., Berger, K.L., Agnew, D.W., McNiel, E.A. 2013. Evaluation of hypoxia in a feline model of head and neck cancer using 64Cu-ATSM positron emission tomography/computed tomography. BMC Cancer.
  5. Pereira, R.J.G., Napolitano, A., Garcia-Pereira, F.L., Baldo, C.F., Suhr, S.T., King, L.E., Cibelli, J.B., Karcher, D.M., McNiel, E.A., Perez, G.I. 2013. Conservation of avian germplasm by xenogeneic transplantation of spermatogonia from sexually mature donors. Stem Cells and Development.
  6. Erfourth, T.M., McNiel, E.A., Scott, M.A., Wilson, D.V. 2012. Use of propofol for induction of anesthesia in dogs undergoing definitive radiation therapy: 31 cases (2006-2009). Journal of the American Veterinary Medical Association.
  7. Rancilio, N.J., Higuchi Dr., T., Gagnon Dr., J., McNiel, E.A. 2012. Use of three-dimensional conformal radiation therapy for treatment of a heart base chemodectoma in a dog. Journal of the American Veterinary Medical Association.
  8. Vail, D.M., von Euler, H., Rusk, A.W., Barber, L., Clifford, C., Elmslie, R., Fulton, L., Hirschberger, J., Klein, M., London, C., Martano, M., McNiel, E.A., Morris, J.S., Northrup, N., Phillips, B., Polton, G., Post, G., Rosenberg, M., Ruslander, D., Sahora, A., Siegel, S., Thamm, D., Westberg, S., Winter, J., Khanna, C. 2012. A Randomized Trial Investigating the Efficacy and Safety of Water Soluble Micellar Paclitaxel (Paccal Vet) for Treatment of Nonresectable Grade 2 or 3 Mast Cell Tumors in Dogs. Journal of Veterinary Internal Medicine.
  9. Husbands, B.D., Mcniel, E.A., Modiano, J.F. 2010. Initial evaluation of safety of wide-field irradiation in the treatment of hematopoietic neoplasia in the cat. Veterinary Radiology and Ultrasound.
  10. Sotirakopoulos, A.J., Armstrong, P.J., Heath, L., Madrill, N.J., McNiel, E.A. 2010. Evaluation of Microsatellite Instability in Urine for the Diagnosis of Transitional Cell Carcinoma of the Lower Urinary Tract in Dogs. Journal of Veterinary Internal Medicine.
  11. Harrison, T.M., Dominguez, P., Hanzlik, K., Sikarskie, J.G., Agnew, D., Bergin, I., Fitzgerald, S.D., Kitchell, B.E., McNiel, E. 2010. Treatment of an amelanotic melanoma using radiation therapy in a lesser madagascar hedgehog tenrec (Echinops telfairi). Journal of Zoo and Wildlife Medicine.
  12. Tobias, A.H., McNiel, E.A. 2008. Pericardial disorders and cardiac tumors. Manual of Canine and Feline Cardiology.
  13. Nadella, M.V.P., Kisseberth, W.C., Nadella, K.S., Thudi, N.K., Thamm, D.H., Mcniel, E.A., Yilmaz, A., Boris-Lawrie, K., Rosol, T.J. 2008. NOD/SCID mouse model of canine T-cell lymphoma with humoral hypercalcaemia of malignancy: Cytokine gene expression profiling and in vivo bioluminescent imaging. Veterinary and Comparative Oncology.
  14. Candolfi, M., Curtin, J.F., Nichols, W.S., Muhammad, A.K.M.G., King, G.D., Pluhar, G.E., McNiel, E.A., Ohlfest, J.R., Freese, A.B., Moore, P.F., Lerner, J., Lowenstein, P.R., Castro, M.G. 2007. Intracranial glioblastoma models in preclinical neuro-oncology: Neuropathological characterization and tumor progression. Journal of Neuro-Oncology.
  15. McNiel, E.A., Griffin, K.L., Mellett, A.M., Madrill, N.J., Mickelson, J.R. 2007. Microsatellite instability in canine mammary gland tumors. Journal of Veterinary Internal Medicine.
  16. Dings, R.P.M., Loren, M., Heun, H., McNiel, E., Griffioen, A.W., Mayo, K.H., Griffin, R.J. 2007. Scheduling of radiation with angiogenesis inhibitors anginex and avastin improves therapeutic outcome via vessel normalization. Clinical Cancer Research.
  17. McNiel, E.A., Carmella, S.G., Health, L.A., Bliss, R.L., Le, K.-A., Hecht, S.S. 2007. Urinary biomarkers to assess exposure of cats to environmental tobacco smoke. American Journal of Veterinary Research.
  18. Candolfi, M., Kroeger, K.M., Pluhar, G.E., Bergeron, J., Puntel, M., Curtin, J.F., McNiel, E.A., Freese, A.B., Ohlfest, J.R., Moore, P., Lowenstein, P.R., Castro, M.G. 2007. Adenoviral-mediated gene transferinto the canine brain in vivo. Neurosurgery.
  19. McNiel, E.A., Madrill, N.J., Treeful, A.E., Buoen, L.C., Weber, A.F. 2006. Comparison of cytogenetics and polymerase chain reaction based detection of the amelogenin gene polymorphism for the diagnosis of freemartinism in cattle. Journal of Veterinary Diagnostic Investigation.
  20. Rassnick, K.M., Goldkamp, C.E., Erb, H.N., Scrivani, P.V., Njaa, B.L., Gieger, T.L., Turek, M.M., McNiel, E.A., Proulx, D.R., Chun, R., Mauldin, G.E., Phillips, B.S., Kristal, O. 2006. Evaluation of factors associated with survival in dogs with untreated nasal carcinomas: 139 Cases (1993-2003). Journal of the American Veterinary Medical Association.

General Research Interests

Cancers occurring in pet animals are common and share morphology, biologic behavior and many molecular features with human cancers. Therefore cancers in pet animals provide a potentially useful means to understand cancers in all species. My roles as a both veterinary clinician and scientist facilitate the combination of molecular and cellular biologic techniques with veterinary clinical investigations. The overarching goals of this research are 1) to improve the ability to prevent, detect, and treat cancer and 2) to develop new animal models for translational cancer research. 

Selected Research Projects

  • Effects of anti-angiogenic therapy in feline oral squamous cell carcinoma.
  • Investigating canine hereditary Gastric carcinoma susceptibility.
  • DNA Mismatch repair in the biology of  bladder cancer.
  • Role of aluminum in feline vaccine-associated carcinogenesis.

Research and Clinical Interests

  • Carcinogenesis
  • Cancer Genetics
  • Radiation Oncology
  • Experimental Therapeutics

Research Interests by Area

Spontaneous Animal Disease Models
  • Lymphoma, osteosarcoma, transitional cell carcinoma, prostatic cancer, hemangiosarcoma, mammary (breast) cancer, squamous cell carcinoma in cats

Research Interests by Organ System and Disease

Oncology and Cancer Research and Clinical Trials
  • Companion animals in translational cancer research, Chromatin Modification in Canine Cancer. Biological mechanisms of cancer; spontaneous animal disease models; radiation oncology.