Cummings School of Veterinary Medicine at Tufts University
Daniela Bedenice

Associate Professor & Residency Director

Respiratory Physiology, Large Animal Medicine

Campus Phone:
508-839-7926

Fax:
508-839-7931

Pager:
508-839-5395

Education

  • Dr. med. vet. - Free University of Berlin, Germany - 1997

Board Certification

  • Diplomate ACVIM (Large Animal) - 2002
  • Diplomate ACVECC (Equine) - 2005

A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2.

Author(s):Tremblay, J.M. | Mukherjee, J. | Leysath, C.E. | Debatis, M. | Ofori, K. | Baldwin, K. | Boucher, C. | Peters, R. | Beamer, G. | Sheoran, A. | Bedenice, D. | Tzipori, S. | Shoemaker, C.B.
Publication year: 2013
Journal / Book title: Infection and immunity

Sequential L-lactate concentration in hospitalised equine neonates: A prospective multicentre study

Author(s):Borchers, A. | Wilkins, P.A. | Marsh, P.M. | Axon, J.E. | Read, J. | Castagnetti, C. | Pantaleon, L. | Clark, C. | Qura'n, L. | Belgrave, R. | Schwarzwald, C. | Levy, M. | Bedenice, D. | Saulez, M.N. | Boston, R.C.
Publication year: 2013
Journal / Book title: Equine Veterinary Journal

Prevalence of mycobacterium avium subsp. paratuberculosis fecal shedding in alpacas presented to veterinary hospitals in the United States

Author(s):Fecteau, M.-E. | Bedenice, D. | Cebra, C.K. | Pinn, T.L. | Mcadams, S.C. | Fyock, T.L. | Whitlock, R.H. | Sweeney, R.W.
Publication year: 2013
Journal / Book title: Journal of Veterinary Internal Medicine

Systemic Distribution of Viral Antigen in Alpacas Persistently Infected With Bovine Pestivirus

Author(s):Henningson, J.N. | Steffen, D.J. | Topliff, C.L. | Kurth, K.L. | Dubielzig, R.R. | Brodersen, B.W. | Bedenice, D. | Eskridge, K.M. | Callan, R.J. | Reggiardo, C. | Rupp, G.P. | Kelling, C.L.
Publication year: 2013
Journal / Book title: Veterinary Pathology

Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection

Author(s):Holmes, K. | Bedenice, D. | Papich, M.G.
Publication year: 2012
Journal / Book title: Journal of Veterinary Pharmacology and Therapeutics

Low tidal volume ventilation in healthy dogs

Author(s):Oura, T. | Rozanski, E.A. | Buckley, G. | Bedenice, D.
Publication year: 2012
Journal / Book title: Journal of Veterinary Emergency and Critical Care

Association of admission L-lactate concentration in hospitalised equine neonates with presenting complaint, periparturient events, clinical diagnosis and outcome: a prospective multicentre study.

Author(s):Borchers, A. | Wilkins, P.A. | Marsh, P.M. | Axon, J.E. | Read, J. | Castagnetti, C. | Pantaleon, L. | Clark, C. | Qura'n, L. | Belgrave, R. | Trachsel, D. | Levy, M. | Bedenice, D. | Saulez, M.N. | Boston, R.C.
Publication year: 2012
Journal / Book title: Equine veterinary journal. Supplement

Association of admission L-lactate concentration in hospitalised equine neonates with presenting complaint, periparturient events, clinical diagnosis and outcome: A prospective multicentre study

Author(s):Borchers, A. | Wilkins, P.A. | Marsh, P.M. | Axon, J.E. | Read, J. | Castagnetti, C. | Pantaleon, L. | Clark, C. | Qura'n, L. | Belgrave, R. | Trachsel, D. | Levy, M. | Bedenice, D. | Saulez, M.N. | Boston, R.C.
Publication year: 2012
Journal / Book title: Equine Veterinary Journal

A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model

Author(s):Mukherjee, J. | Tremblay, J.M. | Leysath, C.E. | Ofori, K. | Baldwin, K. | Feng, X. | Bedenice, D. | Webb, R.P. | Wright, P.M. | Smith, L.A. | Tzipori, S. | Shoemaker, C.B.
Publication year: 2012
Journal / Book title: PLoS ONE

Respiratory mechanics and results of cytologic examination of bronchoalveolar lavage fluid in healthy adult alpacas

Author(s):Pacheco, A.P. | Bedenice, D. | Mazan, M.R. | Hoffman, A.M.
Publication year: 2012
Journal / Book title: American Journal of Veterinary Research

Measurement of corneal sensitivity in 20 ophthalmologically normal alpacas

Author(s):Welihozkiy, A. | Bedenice, D. | Price, L.L. | Pizzirani, S. | Pirie, C.G.
Publication year: 2011
Journal / Book title: Veterinary Ophthalmology

Retrospective evaluation of parenteral nutrition in alpacas: 22 cases (2002-2008)

Author(s):Clore, E.R.S. | Freeman, L.M. | Bedenice, D. | Tony Buffington, C.A. | Anderson, D.E.
Publication year: 2011
Journal / Book title: Journal of Veterinary Internal Medicine

Long-term clinicopathological characteristics of alpacas naturally infected with bovine viral diarrhea virus type Ib

Author(s):Bedenice, D. | Dubovi, E. | Kelling, C.L. | Henningson, J.N. | Topliff, C.L. | Parry, N.
Publication year: 2011
Journal / Book title: Journal of Veterinary Internal Medicine

The effect of body position, sedation, and thoracic bandaging on functional residual capacity in healthy deep-chested dogs

Author(s):Rozanski, E.A. | Bedenice, D. | Lofgren, J. | Abrams, J. | Bach, J. | Hoffman, A.M.
Publication year: 2010
Journal / Book title: Canadian Journal of Veterinary Research

Cardiopulmonary effects of dobutamine and norepinephrine infusion in healthy anesthetized alpacas

Author(s):Vincent, C.J. | Hawley, A.T. | Rozanski, E.A. | Lascola, K.M. | Bedenice, D.
Publication year: 2009
Journal / Book title: American Journal of Veterinary Research

Neurologic Diseases in Llamas and Alpacas

Author(s):Whitehead, C.E. | Bedenice, D.
Publication year: 2009
Journal / Book title: Veterinary Clinics of North America - Food Animal Practice

Approach to the Critically Ill Camelid

Author(s):Bedenice, D.
Publication year: 2009
Journal / Book title: Veterinary Clinics of North America - Food Animal Practice

Genotyping and phylogenetic analysis of bovine viral diarrhea virus isolates from BVDV infected alpacas in North America

Author(s):Kim, S.G. | Anderson, R.R. | Yu, J.Z. | Zylich, N.C. | Kinde, H. | Carman, S. | Bedenice, D. | Dubovi, E.J.
Publication year: 2009
Journal / Book title: Veterinary Microbiology

Concurrent Infection with Anaplasma phagocytophilum and Mycoplasma haemolamae in a young alpaca

Author(s):Lascola, K. | Vandis, M. | Bain, P. | Bedenice, D.
Publication year: 2009
Journal / Book title: Journal of Veterinary Internal Medicine

Humoral response to an equine encephalitis vaccine in healthy alpacas

Author(s):Bedenice, D. | Bright, A. | Pedersen, D.D. | Dibb, J.
Publication year: 2009
Journal / Book title: Journal of the American Veterinary Medical Association

General Research Interests

Comparative respiratory physiology and non-invasive pulmonary function testing (equine, canine, camelid). Large animal neonatal and adult critical care. Emerging infectious diseases in camelids.

Selected Research Projects

  • Characterization of immune responses in juvenile alpacas persistently infected with BVDV. Alpaca Research Foundation (ARF).
  • The cardiovascular effects of dobutamine infusion in healthy, adult, anesthetized alpacas. Empire Alpaca Association.
  • The humoral response to EEE vaccination in healthy alpacas. (ARF).
  • Non-invasive measurement of respiratory resistance (Rrs) using two different oscillatory methods in the horse: Comparative study of impulse oscillometry (IOS) and Monofrequency Forced Oscillatory Mechanics (FOM) in the adult horse, pre and post bronchodilation.
  • Non-invasive measurement of airway resistance (Raw) and functional residual capacity (FRC) in conscious sheep and dogs.
  • Respiratory mechanics in awake adult llamas.

Research Interests by Area

Other Areas of Research
  • Humoral response to vaccination
Regenerative Medicine
  • Regenerative medicine in camelids.
Spontaneous Animal Disease Models
  • Respiratory disease in large animals, COPD, parasitic lung disease

Research Interests by Organ System and Disease

Respiratory Diseases
  • Comparative respiratory physiology and non-invasive pulmonary function testing (equine,canine,camelid). Respiratory disease in horses and alpacas, clinical pharmacology

Major Specialized Equipment

Pulmonary Mechanics Data Acquisition System - XA BioSystem ; Whole Body Plethysmograph ; Canine (Head-Out) Plethysmograph; small Canine Whole Body (unrestrained) Plethysmograph (measurement of PENH); inductance plethysmography (Respitrace ) for measurements of abdominal and rib cage ventilation and thoracoabdominal synchrony; Helium and Carbon Monoxide Monitor (Morgan Scientific - measurement of diffusion capacity of CO and helium dilution using rebreathing, steady state, or single breath method); ventilators; Indirect Calorimeter (Vmax, ViaSys) - resting and exercise energy (VO2, VCO2, RQ), Sato High Speed Treadmill for exercise studies in horses, sheep, dogs, etc.; patient monitoring system (Passport II ), Arterial Blood Gas Analyzer; Computed Tomography (Pickard 5000 Spiral CT and densitometry software); video endoscopy/gastroscopy etc. Clinical pathology, pathology, ultrasound and radiology facilities complement the environment.