Cummings School of Veterinary Medicine at Tufts University
Cynthia R. L. Webster

Professor & Associate Chair

Associate Chair; Cholestatic Liver Disease, Small Animal Medicine

Campus Phone:
508-839-5395

Fax:
508-839-8787

Education

  • DVM - Cornell University - 1985
  • BS - Simmons College - 1978

House Officer Training

  • ACVIM Small Animal Medicine - TCSVM

Board Certification

  • Diplomate, American College of Veterinary Internal Medicine (Small Animal)

Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs

Author(s):Gladwin, N.E. | Penninck, D.G. | Webster, C.R.L.
Publication year: 2014
Journal / Book title: American Journal of Veterinary Research

Thromboelastographic evaluation of dogs with congenital portosystemic shunts

Author(s):Kelley, D. | Lester, C. | Delaforcade, A. | Webster, C.R.L.
Publication year: 2013
Journal / Book title: Journal of Veterinary Internal Medicine

Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cε{lunate} in HUH-NTCP Cells

Author(s):Schonhoff, C.M. | Webster, C.R.L. | Anwer, M.S.
Publication year: 2013
Journal / Book title: Hepatology

Ultrasonographic measurement of the pancreas and pancreatic duct in clinically normal dogs

Author(s):Penninck, D.G. | Zeyen, U. | Taeymans, O.N. | Webster, C.R.
Publication year: 2013
Journal / Book title: American Journal of Veterinary Research

Ultrasonographic and clinicopathological features of feline gastrointestinal eosinophilic sclerosing fibroplasia in four cats

Author(s):Weissman, A. | Penninck, D. | Webster, C. | Hecht, S. | Keating, J. | Craig, L.E.
Publication year: 2013
Journal / Book title: Journal of Feline Medicine and Surgery

Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane

Author(s):Park, S.W. | Schonhoff, C.M. | Webster, C.R.L. | Sawkat Anwer, M.
Publication year: 2012
Journal / Book title: American Journal of Physiology - Gastrointestinal and Liver Physiology

Hepatobiliary Cytoprotective Agents

Author(s):Webster, C.R.L.
Publication year: 2012
Journal / Book title: Canine and Feline Gastroenterology

Portal Vein Thrombosis in 33 Dogs: 1998-2011

Author(s):Respess, M. | O'Toole, T.E. | Taeymans, O. | Rogers, C.L. | Johnston, A. | Webster, C.R.L.
Publication year: 2012
Journal / Book title: Journal of Veterinary Internal Medicine

Coagulation in hepatobiliary disease

Author(s):Kavanagh, C. | Shaw, S. | Webster, C.R.
Publication year: 2011
Journal / Book title: Journal of Veterinary Emergency and Critical Care

cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-jun NH 2-terminal kinase

Author(s):Johnston, A. | Ponzetti, K. | Anwer, M.S. | Webster, C.R.L.
Publication year: 2011
Journal / Book title: American Journal of Physiology - Gastrointestinal and Liver Physiology

Ultrasonographic characterization of feline ileocecocolic abnormalities

Author(s):Taeymans, O. | Holt, N. | Penninck, D.G. | Webster, C.R.
Publication year: 2011
Journal / Book title: Veterinary Radiology and Ultrasound

Portal Hypertension: Pathophysiology, Diagnosis, and Treatment

Author(s):Buob, S. | Johnston, A.N. | Webster, C.R.L.
Publication year: 2011
Journal / Book title: Journal of Veterinary Internal Medicine

Sonographic assessment of gallbladder volume in normal cats

Author(s):Penninck, D.G. | Brisson, J.O. | Webster, C.R.L.
Publication year: 2010
Journal / Book title: Veterinary Radiology and Ultrasound

Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells

Author(s):Hohenester, S. | Gates, A. | Wimmer, R. | Beuers, U. | Anwer, M.S. | Rust, C. | Webster, C.R.L.
Publication year: 2010
Journal / Book title: Journal of Hepatology

Ultrasonographic assessment of long-term enterectomy sites in dogs

Author(s):Mareschal, A. | Penninck, D. | Webster, C.R.L.
Publication year: 2010
Journal / Book title: Veterinary Radiology and Ultrasound

The sonographic appearance of intestinal mucosal fibrosis in cats

Author(s):Penninck, D.G. | Webster, C.R.L. | Keating, J.H.
Publication year: 2010
Journal / Book title: Veterinary Radiology and Ultrasound

Cyclic AMP stimulates Mrp2 translocation by activating p38α MAPK in hepatic cells

Author(s):Schonhoff, C.M. | Webster, C.R.L. | Anwer, M.S.
Publication year: 2010
Journal / Book title: American Journal of Physiology - Gastrointestinal and Liver Physiology

PKCε-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line

Author(s):Schonhoff, C.M. | Yamazaki, A. | Hohenester, S. | Webster, C.R.L. | Bouscarel, B. | Anwer, M.S.
Publication year: 2009
Journal / Book title: American Journal of Physiology - Gastrointestinal and Liver Physiology

Hepatocyte Apoptosis

Author(s):Webster, C.R.L.
Publication year: 2009
Journal / Book title: The Liver: Biology and Pathobiology: Fifth Edition

Therapeutic Use of Cytoprotective Agents in Canine and Feline Hepatobiliary Disease

Author(s):Webster, C.R.L. | Cooper, J.
Publication year: 2009
Journal / Book title: Veterinary Clinics of North America - Small Animal Practice

General Research Interests

  • Cholestatic liver disease in dogs and cats, bile acid hepatotoxicity, hepatocyte apoptosis/survival signaling.

Selected Research Projects

  • Role of cAMP signaling through cAMP-GEF in hepatocyte survival.
  • Role of bile acid apoptosis in cholestatic liver disease.
  • Novel stem cell intervention in cholestatic liver disease in dogs and cats.
  • Coagulation and liver disease.

Teaching

  • Gastrointestinal/hepatic pathology/pharmacology
  • Small animal medicine, gastrointestinal/hepatic medicine
  • Clinical rotations, small animal medicine
  • Pathobiology: Cholestasis

Research Interests by Area

Hepatic Diseases
  • Mechanism of hepatocellular apoptosis; pathophysiology of feline and canine hepatic disorder
  • Pathophysiology of feline and canine hepatic disorders
  • Cholestatic liver disorders in dogs and cats; Coagulation in liver disease in dogs and cats. Basic: Mechanisms of bile formation; bile acid signaling; hepatotoxicity
Regenerative Medicine
  • Clinical application of stem cells for liver disease.
Spontaneous Animal Disease Models
  • Chronic hepatitis in dogs including Labrador hepatopathy, chronic cholangiopathies in cats, gastrointestinal/hepatobiliary neoplasia, hepatic steatosis in cats, hepatic nodular hyperplasia, inflammatory bowel disease, pancreatitis, inflammatory bowel disease, hepatocutaneous syndrome, congenital vascular anomalies, fibropolycystic liver diseases

Major Specialized Equipment

  • Fully equipped cell biology laboratory.
  • Isolation and culture of primary hepatocytes.