Christopher M. Schonhoff

Christopher M. Schonhoff
Research Assistant Professor

Signaling by Nitric Oxide

Campus Phone:
508-887-4357

Education

  • PhD - UMASS Medical School - 2000
  • BS - Boston College - 1992
  1. Schonhoff, C.M., Park, S.W., Webster, C.R.L., Anwer, M.S. 2016. p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  2. Won Park, S., Schonhoff, C.M., Anwer, M.S., Webster, C.R.L. 2014. Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  3. Ramasamy, U., Anwer, M.S., Schonhoff, C.M. 2013. Cysteine 96 of Ntcp is responsible for NO-mediated inhibition of taurocholate uptake. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  4. Schonhoff, C.M., Webster, C.R.L., Anwer, M.S. 2013. Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cε{lunate} in HUH-NTCP Cells. Hepatology.
  5. Park, S.W., Schonhoff, C.M., Webster, C.R.L., Sawkat Anwer, M. 2012. Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  6. Schonhoff, C.M., Benhar, M. 2011. Analysis of protein S-nitrosylation.. Current protocols in protein science / editorial board, John E. Coligan ... [et al.].
  7. Schonhoff, C.M., Benhar, M. 2011. Analysis of protein S-nitrosylation. Current Protocols in Protein Science.
  8. Schonhoff, C.M., Ramasamy, U., Anwer, M.S. 2011. Nitric oxide-mediated inhibition of taurocholate uptake involves S-nitrosylation of NTCP. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  9. Schonhoff, C.M., Webster, C.R.L., Anwer, M.S. 2010. Cyclic AMP stimulates Mrp2 translocation by activating p38α MAPK in hepatic cells. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  10. Schonhoff, C.M., Yamazaki, A., Hohenester, S., Webster, C.R.L., Bouscarel, B., Anwer, M.S. 2009. PKCε-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  11. Godoy, L.C., Muñoz-Pinedo, C., Castro, L., Cardaci, S., Schonhoff, C.M., King, M., Tortora, V., Marin, M., Miao, Q., Jiang, J.F., Kapralov, A., Jemmerson, R., Silkstone, G.G., Patel, J.N., Evans, J.E., Wilson, M.T., Green, D.R., Kagan, V.E., Radi, R., Mannick, J.B. 2009. Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells. Proceedings of the National Academy of Sciences of the United States of America.
  12. Schonhoff, C.M., Thankey, K., Webster, C.R.L., Wakabayashi, Y., Wolkoff, A.W., Anwer, M.S. 2008. Rab4 facilitates cyclic adenosine monophosphate-stimulated bile acid uptake and Na+-taurocholate cotransporting polypeptide translocation. Hepatology.
  13. Mannick, J.B., Schonhoff, C.M. 2008. Measurement of Protein S-Nitrosylation during Cell Signaling. Methods in Enzymology.
  14. Schonhoff, C.M., Gillin, H., Webster, C.R.L., Anwer, M.S. 2008. Protein kinase Cδ mediates cyclic adenosine monophosphate-stimulated translocation of sodium taurocholate cotransporting polypeptide and multidrug resistant associated protein 2 in rat hepatocytes. Hepatology.
  15. Mannick, J.B., Schonhoff, C.M. 2006. Analysis of protein S-nitrosylation.. Current protocols in protein science / editorial board, John E. Coligan ... [et al.].
  16. Schonhoff, C.M., Matsuoka, M., Tummala, H., Johnson, M.A., Estevéz, A.G., Wu, R., Kamaid, A., Ricart, K.C., Hashimoto, Y., Gaston, B., Macdonald, T.L., Xu, Z., Mannick, J.B. 2006. S-nitrosothiol depletion in amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America.
  17. Mannick, J.B., Schonhoff, C.M. 2004. NO means no and yes: Regulation of cell signaling by protein nitrosylation. Free Radical Research.
  18. Schonhoff, C.M., Gaston, B., Mannick, J.B. 2003. Nitrosylation of cytochrome c during apoptosis. Journal of Biological Chemistry.
  19. Mannick, J.B., Schonhoff, C.M. 2002. Nitrosylation: The next phosphorylation?. Archives of Biochemistry and Biophysics.
  20. Schonhoff, C.M., Daou, M.-C., Jones, S.N., Schiffer, C.A., Ross, A.H. 2002. Nitric oxide-mediated inhibition of Hdm2-p53 binding. Biochemistry.

General Research Interests

  • Signaling by nitric oxide, liver physiology and livery pathophysiology

Teaching

  • Course director for Veterinary Biochemistry and Metabloism and OSSF II