Cummings School of Veterinary Medicine at Tufts University
Arlin B. Rogers

Associate Professor

Head, Section of Pathology
Liver Carcinogenesis

Campus Phone:
508-887-4805

Fax:
508-839-7936

Education

  • BS - University of Illinois at Urbana-Champaign - 1988
  • DVM - University of Illinois at Urbana-Champaign - 1990
  • MS - University of Illinois at Urbana-Champaign - 1992
  • PhD - Colorado State University - 2001

Board Certification

  • American College of Veterinary Pathologists

Altering the intestinal microbiota during a critical developmental window has lasting metabolic consequences

Author(s):Cox, L.M. | Yamanishi, S. | Sohn, J. | Alekseyenko, A.V. | Leung, J.M. | Cho, I. | Kim, S.G. | Li, H. | Gao, Z. | Mahana, D. | Zárate Rodriguez, J.G. | Rogers, A.B. | Robine, N. | Loke, P. | Blaser, M.J.
Publication year: 2014
Journal / Book title: Cell

Prolactin prevents hepatocellular carcinoma by restricting innate immune activation of c-Myc in mice

Author(s):Hartwell, H.J. | Petrosky, K.Y. | Fox, J.G. | Horseman, N.D. | Rogers, A.B.
Publication year: 2014
Journal / Book title: Proceedings of the National Academy of Sciences of the United States of America

Early or late antibiotic intervention prevents Helicobacter pylori-induced gastric cancer in a mouse model

Author(s):Zhang, S. | Lee, D.S. | Morrissey, R. | Aponte-Pieras, J.R. | Rogers, A.B. | Moss, S.F.
Publication year: 2014
Journal / Book title: Cancer Letters

Role of Raf kinase inhibitor protein in Helicobacter pylori-mediated signaling in gastric cancer

Author(s):Nisimova, L. | Wen, S. | Cross-Knorr, S. | Rogers, A.B. | Moss, S.F. | Chatterjee, D.
Publication year: 2014
Journal / Book title: Critical Reviews in Oncogenesis

General Research Interests

  • My lab studies the influence of sex on liver cancer vulnerability. Males develop the primary liver cancer hepatocellular carcinoma (HCC) more than twice as often as females. Using molecular approaches and rodent models we are exploring the mechanistic basis for this in order to develop new therapies for prevention and treatment in men and women.

Selected Research Projects

  • Role of Prolactin in Liver Cancer Prevention: The aim of this project is to show how the estrogen-sensitive pituitary hormone prolactin protects the liver from chronic injury and cancer by modulating the amplitude of innate immune signaling in hepatocytes.
  • Epigenetic Basis of Male Liver Cancer Susceptibility. The aim of this project is to show how liver masculinization initiated by testosterone and effected through growth hormone creates an inherent state of vulnerability to cancer in males through STAT5B-dependent chromatin remodeling.

Research Interests by Organ System and Disease

Oncology and Cancer Research and Clinical Trials
  • Liver oncology