Cummings School of Veterinary Medicine at Tufts University
Arlin B. Rogers

Associate Professor

Head, Section of Pathology
Liver Carcinogenesis

Campus Phone:
508-887-4805

Fax:
508-839-7936

Education

  • BS - University of Illinois at Urbana-Champaign - 1988
  • DVM - University of Illinois at Urbana-Champaign - 1990
  • MS - University of Illinois at Urbana-Champaign - 1992
  • PhD - Colorado State University - 2001

Board Certification

  • American College of Veterinary Pathologists
  1. Hines IN, Hartwell HJ, Feng Y, Theve EJ, Hall GA, Hashway S, Connolly J, Fecteau M, Fox JG, Rogers AB. Insulin resistance and metabolic hepatocarcinogenesis with parent-of-origin effects in mice. Am J Pathol. 2011 Dec;179(6):2855-65.
  2. Fox JG, Feng Y, Theve EJ, Fry RC, Raczynski AR, Fiala JLA, Doernte AL, Williams M, McFaline JL, Essigmann JM, Schauer DB, Tannenbaum SR, Dedon PC, Weinman SA, Lemon SM, Rogers AB. Gut microbes define liver cancer risk in mice exposed to chemical and viral transgenic hepatocarcinogens. Gut. 2010 Jan;59(1):88-97.
  3. Theve EJ, Feng Y, Taghizadeh K, Cormier KS, Bell DR, Fox JG, Rogers AB. Sex hormone influence on hepatitis in young male mice infected with Helicobacter hepaticus. Infect Immun. 2008 Sep;76(9):4071-8.
  4. Rogers AB, Theve EJ, Feng Y, Fry RC, Taghizadeh K, Clapp KM, Boussahmain C, Cormier KS, Fox JG. Hepatocellular carcinoma associated with liver-gender disruption in male mice. Cancer Res. 2007 Dec 15;67(24):11536-46.

Web page of publications:

General Research Interests

  • My lab studies the influence of sex on liver cancer vulnerability. Males develop the primary liver cancer hepatocellular carcinoma (HCC) more than twice as often as females. Using molecular approaches and rodent models we are exploring the mechanistic basis for this in order to develop new therapies for prevention and treatment in men and women.

Selected Research Projects

  • Role of Prolactin in Liver Cancer Prevention: The aim of this project is to show how the estrogen-sensitive pituitary hormone prolactin protects the liver from chronic injury and cancer by modulating the amplitude of innate immune signaling in hepatocytes.
  • Epigenetic Basis of Male Liver Cancer Susceptibility. The aim of this project is to show how liver masculinization initiated by testosterone and effected through growth hormone creates an inherent state of vulnerability to cancer in males through STAT5B-dependent chromatin remodeling.

Research Interests by Organ System and Disease

Oncology and Cancer Research and Clinical Trials
  • Liver oncology