Akram Da'darah, M.Sc. Ph.D. is a Associate Professor at the Cummings School of Veterinary Medicine who joined the Molecular Helminthology Laboratory in 2010. Dr. Da’darah studies schistosomiasis, a major human parasitic disease caused by helminth parasites of the genus Schistosoma, also known as “Blood Flukes”. His main research focuses on Host-Parasite interaction. The overall objective of his research is to understand how schistosome parasites are able to survive in the host for several years, as well as to identify novel candidates that can be used as drug targets and/or vaccine candidates.
Prior to joining Tufts University, Akram has worked at the Department of Immunology and Infectious Diseases/Harvard School of Public Health for twelve years as a post-doctoral fellow, a research associate and a scientist. He has extensive experience in studying schistosome parasites.
He received his Ph.D. in Molecular and Biochemical Parasitology in 1997 from Bernhard Nocht Institute for Tropical Medicine/Hamburg University, Germany. His Ph.D. research focused on polyamine metabolic pathway as a drug target for human parasitic diseases. He also obtained a Master's degree in Cytogenetics.
- PhD - Hamburg University, Germany - 1997
- MSc - Yarmouk Univeristy, Jordan - 1992
- BSc - Yarmouk University, Jordan - 1990
- Pirovich, D.B., Da'dara, A.A., Skelly, P.J. 2020. Schistosoma mansoni glyceraldehyde-3-phosphate dehydrogenase enhances formation of the blood-clot lysis protein plasmin. Biology Open.
- Pirovich, D., Da'dara, A.A., Skelly, P.J. 2019. Why Do Intravascular Schistosomes Coat Themselves in Glycolytic Enzymes?. BioEssays.
- Elzoheiry, M., Da'dara, A.A., Nation, C.S., El-Beshbishi, S.N., Skelly, P.J. 2019. Schistosomes can hydrolyze proinflammatory and prothrombotic polyphosphate (polyP) via tegumental alkaline phosphatase, SmAP. Molecular and Biochemical Parasitology.
- Da'Dara, A.A., Li, C., Yu, X., Zheng, M., Zhou, J., Shollenberger, L.M., Li, Y.-S., Harn, D.A. 2019. Prime-boost vaccine regimen for SjTPI and sjc23schistosome vaccines, increase efficacy in water buffalo in a field trial in China. Frontiers in Immunology.
- Elzoheiry, M., Da'Dara, A.A., Delaforcade, A.M., El-Beshbishi, S.N., Skelly, P.J. 2018. The Essential Ectoenzyme SmNPP5 from the Human Intravascular Parasite Schistosoma mansoni is an ADPase and a Potent Inhibitor of Platelet Aggregation. Thrombosis and Haemostasis.
- Wang, Q., Da'Dara, A.A., Skelly, P.J. 2018. The blood fluke Schistosoma mansoni cleaves the coagulation protein high molecular weight kininogen (HK) but does not generate the vasodilator bradykinin. Parasites and Vectors.
- Elzoheiry, M., Da'dara, A.A., Bhardwaj, R., Wang, Q., Azab, M.S., El-Kholy, E.-S.I., El-Beshbishi, S.N., Skelly, P.J. 2018. Intravascular Schistosoma mansoni Cleave the Host Immune and Hemostatic Signaling Molecule Sphingosine-1-Phosphate via Tegumental Alkaline Phosphatase. Frontiers in immunology.
- Wang, Q., Da'dara, A.A., Skelly, P.J. 2017. The human blood parasite Schistosoma mansoni expresses extracellular tegumental calpains that cleave the blood clotting protein fibronectin. Scientific Reports.
- Da'dara, A.A., Siddons, G., Icaza, M., Wang, Q., Skelly, P.J. 2017. How schistosomes alter the human serum proteome. Molecular and Biochemical Parasitology.
- Figueiredo, B.C., Da'dara, A.A., Oliveira, S.C., Skelly, P.J. 2015. Schistosomes Enhance Plasminogen Activation: The Role of Tegumental Enolase. PLoS Pathogens.
- Da'Dara, A.A., Skelly, P.J. 2014. Schistosomes versus platelets. Thrombosis Research.
- Figueiredo, B.C., Assis, N.R.G., Morais, S.B., Ricci, N.D., Pinheiro, C.S., Martins, V.P., Bicalho, R.M., Da'dara, A.A., Skelly, P.J., Oliveira, S.C. 2014. Schistosome Syntenin Partially Protects Vaccinated Mice against Schistosoma mansoni Infection. PLoS Neglected Tropical Diseases.
- Skelly, P.J., Da'dara, A.A., Li, X.-H., Castro-Borges, W., Wilson, R.A. 2014. Schistosome Feeding and Regurgitation. PLoS Pathogens.
- Da'dara, A.A., Bhardwaj, R., Ali, Y.B.M., Skelly, P.J. 2014. Schistosome tegumental ecto-apyrase (SmATPDase1) degrades exogenous pro-inflammatory and pro-thrombotic nucleotides. PeerJ.
- Da'dara, A.A., Faghiri, Z., Krautz-Peterson, G., Bhardwaj, R., Skelly, P.J. 2013. Schistosome Na, K-ATPase as a therapeutic target. Transactions of the Royal Society of Tropical Medicine and Hygiene.
- Grenfell, R., Harn, D.A., Tundup, S., Da'dara, A., Siqueira, L., Coelho, P.M.Z. 2013. New Approaches with Different Types of Circulating Cathodic Antigen for the Diagnosis of Patients with Low Schistosoma mansoni Load. PLoS Neglected Tropical Diseases.
- Farias, L.P., Krautz-Peterson, G., Tararam, C.A., Araujo-Montoya, B.O., Fraga, T.R., Rofatto, H.K., Silva-Jr, F.P., Isaac, L., Da'dara, A.A., Wilson, R.A., Shoemaker, C.B., Leite, L.C.C. 2013. On the Three-Finger Protein Domain Fold and CD59-Like Proteins in Schistosoma mansoni. PLoS Neglected Tropical Diseases.
- Da'dara, A.A., Skelly, P.J. 2012. RNA Interference as a Tool for Drug Discovery in Parasitic Flatworms. Parasitic Helminths: Targets, Screens, Drugs and Vaccines.
- Da'dara, A., Krautz-Peterson, G., Faghiri, Z., Skelly, P.J. 2012. Metabolite movement across the schistosome surface. Journal of Helminthology.
- Bhardwaj, R., Krautz-Peterson, G., Da'dara, A., Tzipori, S., Skelly, P.J. 2011. Tegumental phosphodiesterase SmNPP-5 is a virulence factor for schistosomes. Infection and Immunity.
General Research Interests
- Molecular and Biochemical Parasitology
- Drug Discovery and Development: For parasitic diseases
- Immune regulation and vaccine development.
Selected Research Projects
- Host-Parasite interaction: This project investigates the interactions between schistosome parasites and their host. This will enhance our understanding of the mechanism(s) that allow the parasites to survive in their host for several years. In addition, this will result in the identification of novel therapeutic targets for schistosomiasis.
- Vaccine development for schistosomiasis. This project will evaluate several novel surface parasites proteins as vaccine candidates against schistosome infections.
- Drug development. We use molecular and biochemical approaches to identify novel targets. We perform high throughput drug-screens (in vitro and in vivo) to identify and validate parasite-specific inhibitors which will be developed as a therapy for schistosomiasis.
- Veterinary Molecular Biology (VET 112)
- Microbial Pathogenesis (VET 201)
- Parasite Biology (VET 652)
- Field and Laboratory Techniques (VET 582)
Masters of Infectious Disease and Global Health Curriculum:
- Microbial Molecular Biology (IDGH 548)—Course Director
- Molecular Biology Techniques (IDGH 563)—Course Director
- Journal Club (IDGH 546)—Course Director
- Infectious Diseases of Human and Animals (IDGH 546)
- Animal Models of Infectious Diseases (IDGH 549)
- Research Training
Veterinary Microbiology Laboratory (VET 202)