Cummings School of Veterinary Medicine at Tufts University
Akram Da'darah

Research Assistant Professor

Campus Phone:
508-887-4579

Fax:
508-839-7911

Akram Da'darah, M.Sc. Ph.D. is a Research Assistant Professor at the Cummings School of Veterinary Medicine who joined the Molecular Helminthology Laboratory in 2010. His main research focuses on Host-Parasite interaction in order to understand how schistosome parasites are able to survive in the host for several years. The overall objective of his research is to identify novel candidates that can be used as drug targets and/or vaccine candidates. Prior to joining Tufts University, Akram has worked at the Department of Immunology and Infectious Diseases/Harvard School of Public Health for twelve years as a post-doctoral fellow, a research associate and a scientist. He has extensive experience in studying schistosome parasites.

He received his Ph.D. in Molecular and Biochemical Parasitology in 1997 from Bernhard Nocht Institute for Tropical Medicine/Hamburg University, Germany. His Ph.D. research focused on polyamine metabolic pathway as a drug target for human parasitic diseases. He also obtained a Master's degree in cytogenetics.

Education

  • PhD - Hamburg University, Germany - 1997
  • MSc - Yarmouk Univeristy, Jordan - 1992
  • BSc - Yarmouk University, Jordan - 1990

New insights into the reaction of Schistosoma mansoni cercaria to the human complement system

Author(s):Da'dara, A.A. | Krautz-Peterson, G.
Publication year: 2014
Journal / Book title: Parasitology Research

Schistosome apyrase SmATPDase1, but not SmATPDase2, hydrolyses exogenous ATP and ADP

Author(s):Da'dara, A.A. | Bhardwaj, R. | Skelly, P.J.
Publication year: 2014
Journal / Book title: Purinergic Signalling

Schistosomes versus platelets

Author(s):Da'Dara, A.A. | Skelly, P.J.
Publication year: 2014
Journal / Book title: Thrombosis Research

Schistosome tegumental ecto-apyrase (SmATPDase1) degrades exogenous pro-inflammatory and pro-thrombotic nucleotides

Author(s):Da'dara, A.A. | Bhardwaj, R. | Ali, Y.B.M. | Skelly, P.J.
Publication year: 2014
Journal / Book title: PeerJ

On the Three-Finger Protein Domain Fold and CD59-Like Proteins in Schistosoma mansoni

Author(s):Farias, L.P. | Krautz-Peterson, G. | Tararam, C.A. | Araujo-Montoya, B.O. | Fraga, T.R. | Rofatto, H.K. | Silva-Jr, F.P. | Isaac, L. | Da'dara, A.A. | Wilson, R.A. | Shoemaker, C.B. | Leite, L.C.C.
Publication year: 2013
Journal / Book title: PLoS Neglected Tropical Diseases

Schistosome Na, K-ATPase as a therapeutic target

Author(s):Da'dara, A.A. | Faghiri, Z. | Krautz-Peterson, G. | Bhardwaj, R. | Skelly, P.J.
Publication year: 2013
Journal / Book title: Transactions of the Royal Society of Tropical Medicine and Hygiene

New Approaches with Different Types of Circulating Cathodic Antigen for the Diagnosis of Patients with Low Schistosoma mansoni Load

Author(s):Grenfell, R. | Harn, D.A. | Tundup, S. | Da'dara, A. | Siqueira, L. | Coelho, P.M.Z.
Publication year: 2013
Journal / Book title: PLoS Neglected Tropical Diseases

RNA Interference as a Tool for Drug Discovery in Parasitic Flatworms

Author(s):Da'dara, A.A. | Skelly, P.J.
Publication year: 2012
Journal / Book title: Parasitic Helminths: Targets, Screens, Drugs and Vaccines

Metabolite movement across the schistosome surface

Author(s):Da'dara, A. | Krautz-Peterson, G. | Faghiri, Z. | Skelly, P.J.
Publication year: 2012
Journal / Book title: Journal of Helminthology

Tegumental phosphodiesterase SmNPP-5 is a virulence factor for schistosomes

Author(s):Bhardwaj, R. | Krautz-Peterson, G. | Da'dara, A. | Tzipori, S. | Skelly, P.J.
Publication year: 2011
Journal / Book title: Infection and Immunity

Manipulation of vascular function by blood flukes?

Author(s):Da'dara, A. | Skelly, P.J.
Publication year: 2011
Journal / Book title: Blood Reviews

Type I interferons increase host susceptibility to trypanosoma cruzi infection

Author(s):Chessler, A.C. | Caradonna, K.L. | Da'dara, A. | Burleigh, B.A.
Publication year: 2011
Journal / Book title: Infection and Immunity

Dendritic cells activated by an anti-inflammatory agent induce CD4 + T helper type 2 responses without impairing CD8+ memory and effector cytotoxic T-lymphocyte responses

Author(s):Wang, Y. | Da'Dara, A.A. | Thomas, P.G. | Harn, D.A.
Publication year: 2010
Journal / Book title: Immunology

Elimination of helminth infection restores HIV-1C vaccine-specific T cell responses independent of helminth-induced IL-10

Author(s):Da'dara, A.A. | Harn, D.A.
Publication year: 2010
Journal / Book title: Vaccine

Modulation of host immune responses by helminth glycans

Author(s):Harn, D.A. | McDonald, J. | Atochina, O. | Da'Dara, A.A.
Publication year: 2009
Journal / Book title: Immunological Reviews

The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo

Author(s):Atochina, O. | Da'dara, A.A. | Walker, M. | Harn, D.A.
Publication year: 2008
Journal / Book title: Immunology

DNA-based vaccines protect against zoonotic schistosomiasis in water buffalo

Author(s):Da'Dara, A.A. | Li, Y.S. | Xiong, T. | Zhou, J. | Williams, G.M. | McManus, D.P. | Feng, Z. | Yu, X.L. | Gray, D.J. | Harn, D.A.
Publication year: 2008
Journal / Book title: Vaccine

Helminth infection suppresses T-cell immune response to HIV-DNA-based vaccine in mice

Author(s):Da'Dara, A.A. | Lautsch, N. | Dudek, T. | Novitsky, V. | Lee, T.-H. | Essex, M. | Harn, D.A.
Publication year: 2006
Journal / Book title: Vaccine

Comparison of Schistosoma mansoni irradiated cercariae and Sm23 DNA vaccines

Author(s):Ganley-Leal, L.M. | Guarner, J. | Todd, C.W. | Da'Dara, A.A. | Freeman Jr., G.L. | Boyer, A.E. | Harn, D.A. | Secor, W.E.
Publication year: 2005
Journal / Book title: Parasite Immunology

A helminth glycan induces APC maturation via alternative NF-κB activation independent of IκBα degradation

Author(s):Thomas, P.G. | Carter, M.R. | Da'Dara, A.A. | DeSimone, T.M. | Harn, D.A.
Publication year: 2005
Journal / Book title: Journal of Immunology

General Research Interests

  • Molecular and Biochemical Parasitology
  • Drug research and development: For parasitic diseases
  • Immune regulation and vaccine development.

Selected Research Projects

  1. Host-Parasite interaction.This project investigates the interactions between schistosome parasites and their host. This will enhance our understanding of the mechanism(s) of the parasites survival in the host for several years, as well as allows us to identify and evaluate novel drug targets for schistosomiasis.
  2. Vaccine development for schistosomiasis.This project will evaluate several novel surface parasites proteins as vaccine candidates against schistosome infections.