Assistant Professor Abhineet Sheoran, DVM, PhD, is an immunologist and infectious disease specialist with >15 years of experience on immunology, immunotherapy of toxin-mediated diseases, animal models, and development of vaccines for mucosal pathogens. He jointly runs a program to develop a therapy for hemolytic uremic syndrome (HUS) and a vaccine for cryptosporidiosis with Professor Saul Tzipori. He teaches in several courses in the DVM and graduate programs and directs a course on immunology. He is the director of the newly established twelve-month Master of Science degree program in Infectious Disease and Global Health that starts in Fall 2015.
Dr. Sheoran’s laboratory is engaged in preclinical evaluations of antitoxin agents against Shiga toxin 1 (Stx1) and Stx2 of enterohemorrhagic E. coli (EHEC) in animal models. Stx1 and Stx2 are associated with HUS following infection with EHEC that people contract by eating contaminated vegetables or undercooked meat.
Another project in Dr. Sheoran’s laboratory is to develop a vaccine for cryptosporidiosis, an infection caused by the enteric pathogens Cryptosporidium parvum and C. hominis. Cryptosporidiosis is a globally important zoonotic disease, which is second only to rotavirus as a cause of diarrhea in children < 2 years of age in sub-Saharan Africa and South Asia. Cryptosporidium also causes sporadic diarrheal illness in industrialized countries, including the US. Currently, there is no effective therapy or vaccine against this disease.
Before coming to Tufts, Dr. Sheoran did his doctoral work on equine humoral immunity at the University of Cambridge, England, and pursued his interests in the same field during post-doctoral training at the University of Kentucky, where he worked on developing mucosal vaccines and investigating virulence factors of equine microbial pathogens.
10. Krautz-Peterson G, Chapman-Bonofiglio S, Boisvert K, Feng H, Herman IM, Tzipori S, Sheoran AS. 2008. Intracellular neutralization of Shiga toxin 2 by an A subunit-specific human monoclonal antibody. Infect Immun. 76(5):1931-1939.
11. Feng H, Nie W, Sheoran A, Zhang Q, Tzipori S. 2006. Bile Acids Enhance Invasiveness of Cryptosporidium spp. into Cultured Cells. Infect Immun. 74:3342-3346.
12. Sheoran AS, Feng X, Singh I, Chapman-Bonofiglio S, Kitaka S, Hanawalt J, Nunnari J, Mansfield K, Tumwine JK, Tzipori S, 2005. Monoclonal Antibodies against Enterocytozoon bieneusi of human origin. J Clin Diag Lab Immunol. 12: 1109-1113.
13. Sheoran AS, Chapman-Bonofiglio S, Harvey BR, Mukherjee J, Georgiou G, Donohue-Rolfe A, Tzipori S. 2005. Human antibody against shiga toxin 2 administered to piglets after the onset of diarrhea due to Escherichia coli O157:H7 prevents fatal systemic complications. Infect Immun. 73: 4607-4613.
14. Sheoran AS, Feng X, Kitaka S, Green L, Pearson C, Didier ES, Chapman S, Tumwine JK, Tzipori S. 2005. Purification of Enterocytozoon bieneusi from stool and production of specific antibodies. J Clin Microbiol. 43: 387-392.
15. Tzipori S, Sheoran AS, Akiyoshi D, Donohue-Rolfe A, Trachtman H. 2004. Antibody therapy in the management of shiga toxin-induced hemolytic uremic syndrome. Clinical Microbiol Reviews. 17: 926-941.
16. Sheoran AS, Chapman S, Singh P, Donohue-Rolfe A, Tzipori S. 2003. Stx2-specific human monoclonal antibodies protect mice against lethal infection with Escherichia coli expressing Stx2 variants. Infect Immun. 71:3125-3130.
17. Sheoran AS, Timoney JF, Tinge SA, Sundaram P, Curtiss III R. 2001. Intranasal immunogenicity of a Dcya Dcrp-pabA mutant of S. typhimuriium for the horse.Vaccine. 19: 3591-3599.
18. Sheoran AS, Nally JE, Donahue JM, Smith BJ, Timoney JF. 2000. Antibody isotypes in sera of equine fetuses aborted due to Leptospira interrogans serovar pomona-type kennewicki infection. Vet. Immunol. Immunopathol. 77:301-309.
19. Sheoran AS, Timoney JF, Holmes MA, Karzen, Crisman MV. 2000. Immunoglobulin isotypes in equine sera and nasal mucosal secretions and their neonatal transfer and distribution. Am. J. Vet. Res. 61: 1099-1105.
20. Sheoran AS, Karzenski S, Whalen JW, Crisman MV, Powell DG, Timoney JF. 2000. Prepartum equine rotavirus vaccination inducing strong specific IgG in mammary secretions. Vet. Rec.146: 672-673.
PhD and Master’s Degree Curriculum