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Nicholas Frank - DVM, PhD, DACVIM

Nicholas Frank
Internal Medicine, Endocrinology, Obesity, and Laminitis
Large Animal Internal Medicine

Education

  • BSc. Hons. Biology University of North Carolina 1989
  • DVM Purdue University 1993
  • PhD Purdue University 2002

Board Certification

  • Diplomate ACVIM
  1. Frank, N. 2018. Endocrine Disorders of the Equine Athlete. Veterinary Clinics of North America - Equine Practice.
  2. Mueller, M.K., Sween, C., Frank, N., Paradis, M.R. 2018. Survey of human-horse relationships and veterinary care for geriatric horses. Journal of the American Veterinary Medical Association.
  3. Newkirk, K.M., Ehrensing, G., Odoi, A., Boston, R.C., Frank, N. 2018. Immunohistochemical expression of insulin, glucagon, and somatostatin in pancreatic islets of horses with and without insulin resistance. American Journal of Veterinary Research.
  4. Frank, N., Walsh, D.M. 2017. Repeatability of Oral Sugar Test Results, Glucagon-Like Peptide-1 Measurements, and Serum High-Molecular-Weight Adiponectin Concentrations in Horses. Journal of Veterinary Internal Medicine.
  5. Frank, N., Hermida, P., Sanchez-Londoño, A., Singh, R., Gradil, C.M., Uricchio, C.K. 2017. Blood Glucose and Insulin Concentrations after Octreotide Administration in Horses With Insulin Dysregulation. Journal of Veterinary Internal Medicine.
  6. Durham, A.E., Bailey, S.R., Frank, N., McFarlane, D., Schott, H.C., Paradis, M.R. 2017. Science-in-brief: Workshop report The Dorothy Havemeyer International Equine Endocrinology Summit. Equine Veterinary Journal.
  7. Banse, H.E., Holbrook, T.C., Frank, N., McFarlane, D. 2016. Relationship of skeletal muscle inflammation with obesity and obesity-associated hyperinsulinemia in horses. Canadian Journal of Veterinary Research.
  8. Restifo, M.M., Frank, N., Hermida, P., Sanchez-Londoño, A. 2016. Effects of withholding feed on thyrotropin-releasing hormone stimulation test results and effects of combined testing on oral sugar test and thyrotropin-releasing hormone stimulation test results in horses. American Journal of Veterinary Research.
  9. Chameroy, K.A., Frank, N., Elliott, S.B., Boston, R.C. 2016. Comparison of Plasma Active Glucagon-Like Peptide 1 Concentrations in Normal Horses and Those With Equine Metabolic Syndrome and in Horses Placed on a High-Grain Diet. Journal of Equine Veterinary Science.
  10. Hart, K.A., Wochele, D.M., Norton, N.A., Mcfarlane, D., Wooldridge, A.A., Frank, N. 2016. Effect of Age, Season, Body Condition, and Endocrine Status on Serum Free Cortisol Fraction and Insulin Concentration in Horses. Journal of Veterinary Internal Medicine.
  11. McKinney, C., Mueller, M.K., Frank, N. 2015. Effects of Therapeutic Riding on Measures of Stress in Horses. Journal of Equine Veterinary Science.
  12. Banse, H.E., Frank, N., Kwong, G.P.S., McFarlane, D. 2015. Relationship of oxidative stress in skeletal muscle with obesity and obesity-associated hyperinsulinemia in horses. Canadian Journal of Veterinary Research.
  13. Goodale, L., Frank, N., Hermida, P., D’Oench, S. 2015. Evaluation of a thyrotropin-releasing hormone solution stored at room temperature for pituitary pars intermedia dysfunction testing in horses. American Journal of Veterinary Research.
  14. Frank, N. 2014. Pituitary Pars Intermedia Dysfunction. Robinson's Current Therapy in Equine Medicine: Seventh Edition.
  15. Frank, N. 2014. Equine Metabolic Syndrome. Robinson's Current Therapy in Equine Medicine: Seventh Edition.
  16. Frank, N., Tadros, E.M. 2014. Insulin dysregulation. Equine Veterinary Journal.
  17. Frank, N., Geor, R. 2014. Current best practice in clinical management of equine endocrine patients. Equine Veterinary Education.
  18. Villagrán, C.C., Frank, N., Schumacher, J., Reel, D. 2014. Persistent hypercalcemia and hyperparathyroidism in a horse. Case Report in Veterinary Medicine.
  19. Schuver, A., Frank, N., Chameroy, K.A., Elliott, S.B. 2014. Assessment of insulin and glucose dynamics by using an oral sugar test in horses. Journal of Equine Veterinary Science.
  20. Tadros, E.M., Frank, N., Horohov, D.W. 2013. Inflammatory cytokine gene expression in blood during the development of oligofructose-induced laminitis in horses. Journal of Equine Veterinary Science.

General Research Interests

  • Internal medicine
  • Comparative endocrinology
  • Metabolism
  • Nutrition
  • Gastroenterology

Selected Research Projects

  • Endotoxemia as a predisposing factor for laminitis
  • Effects of clinical endotoxemia on glucose metabolism in horses
  • Levothyroxine as a treatment for insulin resistance
  • Effects of resting insulin sensitivity on the acute response to endotoxin in horses
  • Effects of combining endotoxemia and alimentary carbohydrate overload on glucose and insulin dynamics in horses
  • Improved diagnosis and monitoring of equine endocrine disorders
  • Development of an optimal protocol for evaluating insulin secretion and sensitivity in horses
  • A study of the alterations in glucose and lipid metabolism that accompany the development of laminitis in horses
  • Evaluating the effects of endotoxin on glucose dynamics in horses using intravenous glucose tolerance test and euglycemic hyperinsulinemic clamp techniques

Research and Clinical Interests

  • Diagnosis and management of endocrine disorders
  • Equine Metabolic Syndrome
  • Cushings disease
  • Laminitis
  • Endotoxemia
  • Obesity
  • Insulin resistance
  • Diabetes mellitus
  • Incretin hormones
  • Adipokines
  • Electrolyte disorders
  • Nutritional diseases
  • Gastroenterology
  • Geriatric medicine
  • Neonatology

Research Interests by Area

Spontaneous Animal Disease Models
  • Animal models of obesity, metabolic syndrome, equine Cushing's, and aging

Research Interests by Organ System and Disease

Nutritional Basis of Diseases
  • Obesity, insulin resistance, and beta cell function and lipid metabolism.
Endocrinology
  • Insulin resistance, diabetes mellitis, hyperadrenocorticism. Laminitis in horses. Obesity.

Professional organizations

  • American Veterinary Medical Association
  • American College of Veterinary Internal Medicine

Research Sponsor Interest

  • American College of Veterinary Internal Medicine Foundation
  • American Quarter Horse Foundation
  • Grayson Jockey Club Foundation
  • United States Equestrian Federation