Cummings School of Veterinary Medicine at Tufts University
Nicholas Frank

Department Chair; Internal Medicine, Endocrinology, Obesity, and Laminitis

Large Animal Internal Medicine

Education

  • BSc. Hons. Biology University of North Carolina 1989
  • DVM Purdue University 1993
  • PhD Purdue University 2002

Board Certification

  • Diplomate ACVIM
  1. Tóth F, Frank N, Elliott SB, Geor RJ, Boston RC. Effects of an intravenous endotoxin challenge on glucose and insulin dynamics in mares.  Am J Vet Res 2008; 82-88.˜
  2. Tóth F, Frank N, Elliott SB, Geor RJ, Boston RC. Effects of an intravenous endotoxin challenge on glucose and insulin dynamics in mares. Am J Vet Res 2008; 82-88.
  1. Chameroy KA, Frank N, Elliott SB, Boston RC. Effects of a supplement containing chromium and magnesium on morphometric measurements, resting glucose, insulin concentrations and insulin sensitivity in laminitic obese horses. Equine Vet J. 2011 Jul;43(4):494-9.
  2. Frank N. Equine metabolic syndrome. Vet Clin North Am Equine Pract. 2011 Apr;27(1):73-92.
  3. Frank N, Elliott SB, Chameroy KA, TĚth F, Chumbler NS, McClamroch R. Effects of season and pasture grazing on blood hormone and metabolite concentrations in horses with a presumptive diagnosis of pituitary pars intermedia dysfunction (PPID).  J Vet Intern Med 2010;24:1167-1175.
  4. Frank N, Geor RJ, Bailey SR, Durham AE, Johnson PJ. ACVIM consensus statement: Equine Metabolic Syndrome. J Vet Intern Med 2010;24:467-475.
  5. TĚth F, Frank N, Martin-Jiménez, Elliott SB, Geor RJ, Boston RC.  Measurement of C-peptide concentrations and responses to somatostatin, glucose infusion, and insulin resistance in horses.  Equine Vet J 2010;42:149-155
  6. Buchheit TM, Sommardahl CS,  Frank N, Roberson JR. Use of a constant-rate infusion of insulin for the treatment of hyperglycemic, hypernatremic, hyperosmolar syndrome in an alpaca cria.  J Am Vet Med Assoc 2010;236:562-566.
  7. TĚth F, Frank N, Geor RJ, Boston RC.  Effects of pretreatment with dexamethasone or levothyroxine sodium on endotoxin-induced alterations in glucose and insulin dynamics in horses.  Am J Vet Res 2010;71:60-68.
  8. TĚth F, Frank N, Boston RC.  Effects of endotoxemia and carbohydrate overload on glucose and insulin dynamics and the development of laminitis in horses. Equine Vet J 2009;41:852-858.
  9. TĚth F, Frank N, Elliott SB, Perdue K, Geor RJ, Boston RC.  Optimisation of the frequently sampled intravenous glucose tolerance test to reduce urinary glucose spilling in horses. Equine Vet J 2009;41:844-851
  10. Carter RA, McCutcheon LJ, George LA, Smith TL, Frank N, Geor RJ. Effects of diet-induced weight gain on insulin sensitivity and plasma hormone and lipid concentrations in horses. Am J Vet Res 2009;70:1250-1258.
  11. Kalck KA, Frank N, Elliott SB, et al. Use of a low-dose oligofructose overload model to induce laminitis in horses and associated alterations in glucose dynamics.  Am J Vet Res 2009;70:624-632.
  12. Geor R, Frank N. Metabolic syndrome – from human organ disease to laminar failure in equids.  Vet Immunol Immunopathol 2009; 129:151-154.
  13. Frank N, Buchanan BR, Elliott SB.  Effects of long-term oral administration of levothyroxine sodium on serum thyroid hormone concentrations, routine blood test results, and echocardiographic measurements in healthy adult mares.  Am J Vet Res 2008; 69: 68-75.
  14. Frank N, Elliott SB, Boston RC.  Effects of long-term oral administration of levothyroxine sodium on glucose dynamics in healthy adult mares.  Am J Vet Res 2008; 69: 76-81.
  15. TĚth F, Frank N, Elliott SB, Geor RJ, Boston RC. Effects of an intravenous endotoxin challenge on glucose and insulin dynamics in mares.  Am J Vet Res 2008; 82-88.

General Research Interests

  • Internal medicine
  • Comparative endocrinology
  • Metabolism
  • Nutrition
  • Gastroenterology

Selected Research Projects

  • Endotoxemia as a predisposing factor for laminitis
  • Effects of clinical endotoxemia on glucose metabolism in horses
  • Levothyroxine as a treatment for insulin resistance
  • Effects of resting insulin sensitivity on the acute response to endotoxin in horses
  • Effects of combining endotoxemia and alimentary carbohydrate overload on glucose and insulin dynamics in horses
  • Improved diagnosis and monitoring of equine endocrine disorders
  • Development of an optimal protocol for evaluating insulin secretion and sensitivity in horses
  • A study of the alterations in glucose and lipid metabolism that accompany the development of laminitis in horses
  • Evaluating the effects of endotoxin on glucose dynamics in horses using intravenous glucose tolerance test and euglycemic hyperinsulinemic clamp techniques

Research Interests by Area

Spontaneous Animal Disease Models
  • Animal models of obesity, metabolic syndrome, equine Cushing's, and aging

Research Interests by Organ System and Disease

Nutritional Basis of Diseases
  • Obesity, insulin resistance, and beta cell function and lipid metabolism.
Endocrinology
  • Insulin resistance, diabetes mellitis, hyperadrenocorticism. Laminitis in horses. Obesity.

Professional organizations

  • American Veterinary Medical Association
  • American College of Veterinary Internal Medicine

Research Sponsor Interest

  • American College of Veterinary Internal Medicine Foundation
  • American Quarter Horse Foundation
  • Grayson Jockey Club Foundation
  • United States Equestrian Federation