Cummings School of Veterinary Medicine at Tufts University
Nicholas Frank

Department Chair; Internal Medicine, Endocrinology, Obesity, and Laminitis

Large Animal Internal Medicine

Education

  • BSc. Hons. Biology University of North Carolina 1989
  • DVM Purdue University 1993
  • PhD Purdue University 2002

Board Certification

  • Diplomate ACVIM

Current best practice in clinical management of equine endocrine patients

Author(s):Frank, N. | Geor, R.
Publication year: 2014
Journal / Book title: Equine Veterinary Education

Assessment of insulin and glucose dynamics by using an oral sugar test in horses

Author(s):Schuver, A. | Frank, N. | Chameroy, K.A. | Elliott, S.B.
Publication year: 2014
Journal / Book title: Journal of Equine Veterinary Science

Insulin dysregulation

Author(s):Frank, N. | Tadros, E.M.
Publication year: 2014
Journal / Book title: Equine Veterinary Journal

Inflammatory cytokine gene expression in blood during the development of oligofructose-induced laminitis in horses

Author(s):Tadros, E.M. | Frank, N. | Horohov, D.W.
Publication year: 2013
Journal / Book title: Journal of Equine Veterinary Science

Effects of intravenous lipopolysaccharide infusion on glucose and insulin dynamics in horses with equine metabolic syndrome

Author(s):Tadros, E.M. | Frank, N. | De Witte, F.G. | Boston, R.C.
Publication year: 2013
Journal / Book title: American Journal of Veterinary Research

Effects of equine metabolic syndrome on inflammatory responses of horses to intravenous lipopolysaccharide infusion

Author(s):Tadros, E.M. | Frank, N. | Donnell, R.L.
Publication year: 2013
Journal / Book title: American Journal of Veterinary Research

Characterization of blood lipoproteins and validation of cholesterol and triacylglycerol assays for free-ranging polar bears (Ursus maritimus)

Author(s):Whiteman, J.P. | Frank, N. | Greller, K.A. | Harlow, H.J. | Ben-David, M.
Publication year: 2013
Journal / Book title: Journal of Veterinary Diagnostic Investigation

Endocrine disorders and laminitis

Author(s):Tadros, E.M. | Frank, N.
Publication year: 2013
Journal / Book title: Equine Veterinary Education

Effects of a "two-hit" model of organ damage on the systemic inflammatory response and development of laminitis in horses

Author(s):Tadros, E.M. | Frank, N. | Newkirk, K.M. | Donnell, R.L. | Horohov, D.W.
Publication year: 2012
Journal / Book title: Veterinary Immunology and Immunopathology

Effects of continuous or intermittent lipopolysaccharide administration for 48 hours on the systemic inflammatory response in horses

Author(s):Tadros, E.M. | Frank, N.
Publication year: 2012
Journal / Book title: American Journal of Veterinary Research

Association of Asinine Herpesvirus-5 with Pyogranulomatous Pneumonia in a Mare

Author(s):De Witte, F.G. | Frank, N. | Wilkes, R.P. | Novak, J.M.
Publication year: 2012
Journal / Book title: Journal of Veterinary Internal Medicine

Effects of a supplement containing chromium and magnesium on morphometric measurements, resting glucose, insulin concentrations and insulin sensitivity in laminitic obese horses

Author(s):Chameroy, K.A. | Frank, N. | Elliott, S.B. | Boston, R.C.
Publication year: 2011
Journal / Book title: Equine Veterinary Journal

Equine Metabolic Syndrome

Author(s):Frank, N.
Publication year: 2011
Journal / Book title: Veterinary Clinics of North America - Equine Practice

Association of season and pasture grazing with blood hormone and metabolite concentrations in horses with presumed pituitary pars intermedia dysfunction

Author(s):Frank, N. | Elliott, S.B. | Chameroy, K.A. | Tóth, F. | Chumbler, N.S. | McClamroch, R.
Publication year: 2010
Journal / Book title: Journal of Veterinary Internal Medicine

Equine metabolic syndrome

Author(s):Frank, N. | Geor, R.J. | Bailey, S.R. | Durham, A.E. | Johnson, P.J.
Publication year: 2010
Journal / Book title: Journal of Veterinary Internal Medicine

Measurement of C-peptide concentrations and responses to somatostatin, glucose infusion, and insulin resistance in horses

Author(s):Tóth, F. | Frank, N. | Martin-Jiménez, T. | Elliott, S.B. | Geor, R.J. | Boston, R.C.
Publication year: 2010
Journal / Book title: Equine Veterinary Journal

Use of a constant rate infusion of insulin for the treatment of hyperglycemic, hypernatremic, hyperosmolar syndrome in an alpaca cria

Author(s):Buchheit, T.M. | Sommardahl, C.S. | Frank, N. | Roberson, J.R.
Publication year: 2010
Journal / Book title: Journal of the American Veterinary Medical Association

Effects of pretreatment with dexamethasone or levothyroxine sodium on endotoxin-induced alterations in glucose and insulin dynamics in horses

Author(s):Tóth, F. | Frank, N. | Geor, R.J. | Boston, R.C.
Publication year: 2010
Journal / Book title: American Journal of Veterinary Research

Effects of endotoxaemia and carbohydrate overload on glucose and insulin dynamics and the development of laminitis in horses

Author(s):Tóth, F. | Frank, N. | Chameroy, K.A. | Boston, R.C.
Publication year: 2009
Journal / Book title: Equine Veterinary Journal

Optimisation of the frequently sampled intravenous glucose tolerance test to reduce urinary glucose spilling in horses

Author(s):Tóth, F. | Frank, N. | Elliott, S.B. | Perdue, K. | Geor, R.J. | Boston, R.C.
Publication year: 2009
Journal / Book title: Equine Veterinary Journal

General Research Interests

  • Internal medicine
  • Comparative endocrinology
  • Metabolism
  • Nutrition
  • Gastroenterology

Selected Research Projects

  • Endotoxemia as a predisposing factor for laminitis
  • Effects of clinical endotoxemia on glucose metabolism in horses
  • Levothyroxine as a treatment for insulin resistance
  • Effects of resting insulin sensitivity on the acute response to endotoxin in horses
  • Effects of combining endotoxemia and alimentary carbohydrate overload on glucose and insulin dynamics in horses
  • Improved diagnosis and monitoring of equine endocrine disorders
  • Development of an optimal protocol for evaluating insulin secretion and sensitivity in horses
  • A study of the alterations in glucose and lipid metabolism that accompany the development of laminitis in horses
  • Evaluating the effects of endotoxin on glucose dynamics in horses using intravenous glucose tolerance test and euglycemic hyperinsulinemic clamp techniques

Research Interests by Area

Spontaneous Animal Disease Models
  • Animal models of obesity, metabolic syndrome, equine Cushing's, and aging

Research Interests by Organ System and Disease

Nutritional Basis of Diseases
  • Obesity, insulin resistance, and beta cell function and lipid metabolism.
Endocrinology
  • Insulin resistance, diabetes mellitis, hyperadrenocorticism. Laminitis in horses. Obesity.

Professional organizations

  • American Veterinary Medical Association
  • American College of Veterinary Internal Medicine

Research Sponsor Interest

  • American College of Veterinary Internal Medicine Foundation
  • American Quarter Horse Foundation
  • Grayson Jockey Club Foundation
  • United States Equestrian Federation