Cummings School of Veterinary Medicine at Tufts University
Melissa Mazan

Internal Medicine, Equine Respiratory System, Lung Function

Director of Equine Sports Medicine Program

Dr. Melissa Mazan is an Associate Professor and Director of the Equine Sports Medicine program at the Cummings School of Veterinary Medicine's Hospital for Large Animals. Lung function, she notes, is essential to the success of equine athletes, and optimizing performance for competing horses is a particular thrill for her. Dr. Mazan is proudest of the collaboration she has undertaken with Dr.Andrew Hoffman in the area of equine inflammatory airway disease, which affects as many as 80 percent of stabled horses and has provided pathways to better understanding similar human diseases, such as emphysema.

Dr. Mazan also teaches courses on medicine, toxicology, parasitology, and exercise physiology at the Cummings School, where she was drawn by the opportunity to combine research, clinical work, and teaching.

Dr. Mazan enjoys hiking, playing the piano, and spending time with family and friends. She is married to Edward Deveney, a physicist who teaches at Bridgewater State College. They have two daughters, Chloe and Rae. They also share their house with two cats and a dog. Dr. Mazan and her family reside in North Grafton, Massachusetts.

Education

  • DVM - Tufts University School of Veterinary Medicine - 1993
  • BA - Yale University - 1983

Board Certification

  • American College of Veterinary Internal Medicine

Age effects on blood gas, spirometry, airway reactivity, and bronchoalveolar lavage fluid cytology in clinically healthy horses

Author(s):Pacheco, A.P. | Paradis, M.R. | Hoffman, A.M. | Hermida, P. | Sanchez, A. | Nadeau, J.A. | Tufts, M. | Mazan, M.R.
Publication year: 2014
Journal / Book title: Journal of Veterinary Internal Medicine

Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol

Author(s):Mazan, M.R. | Lascola, K. | Bruns, S.J. | Hoffman, A.M.
Publication year: 2014
Journal / Book title: Canadian Journal of Veterinary Research

Endogenous distal airway progenitor cells, lung mechanics, and disproportionate lobar growth following long-term postpneumonectomy in mice

Author(s):Eisenhauer, P. | Earle, B. | Loi, R. | Sueblinvong, V. | Goodwin, M. | Allen, G.B. | Lundblad, L. | Mazan, M.R. | Hoffman, A.M. | Weiss, D.J.
Publication year: 2013
Journal / Book title: Stem Cells

Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema

Author(s):Ingenito, E.P. | Tsai, L. | Murthy, S. | Tyagi, S. | Mazan, M. | Hoffman, A.
Publication year: 2012
Journal / Book title: Cell Transplantation

Respiratory mechanics and results of cytologic examination of bronchoalveolar lavage fluid in healthy adult alpacas

Author(s):Pacheco, A.P. | Bedenice, D. | Mazan, M.R. | Hoffman, A.M.
Publication year: 2012
Journal / Book title: American Journal of Veterinary Research

Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung

Author(s):Hoffman, A.M. | Paxson, J.A. | Mazan, M.R. | Davis, A.M. | Tyagi, S. | Murthy, S. | Ingenito, E.P.
Publication year: 2011
Journal / Book title: Stem Cells and Development

Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myofibroblastic differentiation

Author(s):Paxson, J.A. | Gruntman, A. | Parkin, C.D. | Mazan, M.R. | Davis, A. | Ingenito, E.P. | Hoffman, A.M.
Publication year: 2011
Journal / Book title: PLoS ONE

Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice

Author(s):Hoffman, A.M. | Shifren, A. | Mazan, M.R. | Gruntman, A.M. | Lascola, K.M. | Nolen-Walston, R.D. | Kim, C.F. | Tsai, L. | Pierce, R.A. | Mecham, R.P. | Ingenito, E.P.
Publication year: 2010
Journal / Book title: American Journal of Physiology - Lung Cellular and Molecular Physiology

Global gene expression patterns in the post-pneumonectomy lung of adult mice

Author(s):Paxson, J.A. | Parkin, C.D. | Iyer, L.K. | Mazan, M.R. | Ingenito, E.P. | Hoffman, A.M.
Publication year: 2009
Journal / Book title: Respiratory Research

Perspectives in professional education a description of the tufts cummings school of veterinary medicine-Massachusetts equine clinic combined equine medicine internship program

Author(s):Mazan, M.R. | Merriam, J.
Publication year: 2009
Journal / Book title: Journal of the American Veterinary Medical Association

A description of the Tufts Cummings School of Veterinary Medicine-Massachusetts Equine Clinic combined equine medicine internship program.

Author(s):Mazan, M.R. | Merriam, J.
Publication year: 2009
Journal / Book title: Journal of the American Veterinary Medical Association

Questionnaire assessment of airway disease symptoms in equine barn personnel

Author(s):Mazan, M.R. | Svatek, J. | Maranda, L. | Christiani, D. | Ghio, A. | Nadeau, J. | Hoffman, A.M.
Publication year: 2009
Journal / Book title: Occupational Medicine

Reproducibility of airway responsiveness in horses using flowmetric plethysmography and histamine bronchoprovocation

Author(s):Nolen-Walston, R.D. | Kuehn, H. | Boston, R.C. | Mazan, M.R. | Wilkins, P.A. | Bruns, S. | Hoffman, A.M.
Publication year: 2009
Journal / Book title: Journal of Veterinary Internal Medicine

Association between cough and cytology of bronchoalveolar lavage fluid and pulmonary function in horses diagnosed with inflammatory airway disease

Author(s):Bedenice, D. | Mazan, M.R. | Hoffman, A.M.
Publication year: 2008
Journal / Book title: Journal of Veterinary Internal Medicine

Cellular kinetics and modeling of bronchioalveolar stem cell response during lung regeneration

Author(s):Nolen-Walston, R.D. | Kim, C.F. | Mazan, M.R. | Ingenito, E.P. | Gruntman, A.M. | Tsai, L. | Boston, R. | Woolfenden, A.E. | Jacks, T. | Hoffman, A.M.
Publication year: 2008
Journal / Book title: American Journal of Physiology - Lung Cellular and Molecular Physiology

Bronchoscopic measurement of collateral ventilation in a sheep model of emphysema

Author(s):Tsai, L.W. | Hoffman, A.M. | Mazan, M.R. | Ingenito, E.P.
Publication year: 2007
Journal / Book title: Respiration

Respiratory mechanics in sedated and nonsedated adult llamas

Author(s):Lascola, K.M. | Hoffman, A.M. | Mazan, M.R. | Bedenice, D.
Publication year: 2007
Journal / Book title: American Journal of Veterinary Research

Plethysmographic comparison of breathing pattern in heaves (recurrent airway obstruction) versus experimental bronchoconstriction or hyperpnea in horses

Author(s):Hoffman, A.M. | Oura, T.J. | Riedelberger, K.J. | Mazan, M.R.
Publication year: 2007
Journal / Book title: Journal of Veterinary Internal Medicine

Noninfectious Respiratory Problems

Author(s):Mazan, M.R. | Paradis, M.R.
Publication year: 2006
Journal / Book title: Equine Neonatal Medicine

Restrained whole body plethysmography for measure of strain-specific and allergen-induced airway responsiveness in conscious mice

Author(s):Lofgren, J.L.S. | Mazan, M.R. | Ingenito, E.P. | Lascola, K. | Seavey, M. | Walsh, A. | Hoffman, A.M.
Publication year: 2006
Journal / Book title: Journal of Applied Physiology

General Research Interests

  • The equine respiratory system: Pathophysiology of small airway inflammatory disease - airway smooth muscle
  • Effects of particulate matter air pollution on equine respiratory disease
  • Resting energy in horses with recurrent airway obstruction
  • Non-invasive lung function testing
  • Stem cell applications in equine internal medicine
  • Role of the trophic macrophage in lung regeneration

Teaching

  • Director of TCSVM/Massachusetts Equine Clinic Large Animal Medicine Internship
  • Equine sports medicine, equine exercise physiology, respiratory pathophysiology

Research Interests by Area

Regenerative Medicine
  • Stem cell applications for respiratory disease and systemic inflammation.
Spontaneous Animal Disease Models
  • Airway disease in horses, COPD, regenerative medicine

Research Interests by Organ System and Disease

Respiratory Diseases
  • Dynamics of bronchioalveolar stem cell response to sublethal hyperoxia and recovery in mice. Respiratory: Role of the macrophage; environmental respiratory disease (animal models); stem cell applications