Dr. Melissa Mazan is an Associate Professor and Director of the Equine Sports Medicine program at the Cummings School of Veterinary Medicine's Hospital for Large Animals. Lung function, she notes, is essential to the success of equine athletes, and optimizing performance for competing horses is a particular thrill for her. Dr. Mazan is proudest of the collaboration she has undertaken with Dr.Andrew Hoffman in the area of equine inflammatory airway disease, which affects as many as 80 percent of stabled horses and has provided pathways to better understanding similar human diseases, such as emphysema.
Dr. Mazan also teaches courses on medicine, toxicology, parasitology, and exercise physiology at the Cummings School, where she was drawn by the opportunity to combine research, clinical work, and teaching.
Dr. Mazan enjoys hiking, playing the piano, and spending time with family and friends. She is married to Edward Deveney, a physicist who teaches at Bridgewater State College. They have two daughters, Chloe and Rae. They also share their house with two cats and a dog. Dr. Mazan and her family reside in North Grafton, Massachusetts.
- DVM - Tufts University School of Veterinary Medicine - 1993
- BA - Yale University - 1983
- American College of Veterinary Internal Medicine
- Pacheco A, Bedenice D, Mazan M, Hoffman AM. Respiratory mechanics and results of cytologic examination of bronchoalveolar lavage fluid in healthy adult alpacas. Am J Vet Res 2012; Jan;73:146-152.
- Ingenito EP, Tsai L, Murthy S, Tyagi S, Mazan M, Hoffman A. Autologious lung-derived mesenchymal stem cell transplantation in experimental emphysema. Cell Transplant. 2012:21(1):175-189.
- Paxson JA, Gruntman A, Parkin CD, Mazan MR, Davis A, Ingenito EP, Hoffman AM. Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myfibroblastic differentiation. PLoS One 2011:6(8):e23232.
- Hoffman AM, Paxson JA, Mazan MR, Davis AM, Tyagi S, Murthy S, Ingenito EP. Lung derived mesenchymal stromal cell post-transplantaion survival, persistence, paracrine expression, and repair of elastase injured lung. Stem Cells Dev 2011;Oct:20(10)1779-1792.
- Hoffman AM, Shifren A, Mazan MR, Gruntman AM, LAscola K, Nolen-Walston R, Kim CF, Tsai L, Pierce RA, Mecham R, and Ingenito EP. Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice. Am J Physiol: Lung Cell Mol Physiol 2010;298:L158-168. PMID 19915155.
- Paxson J, Parkin C, Iyer L, Mazan MR, Ingenito EP, and Hoffman AM. Global gene expression patterns during post-pneumonectomy lung regeneration in adult mice. Resp Res 2009:10:92. PMID 19804646.
- Nolen-Walston RD, Kuehn H, Boston RC, Mazan MR, Wilkins PA, Bruns S, Hoffman AM. Reproducibility of airway responsiveness in horses using flowmetric plethysmography and histamine bronchoprovocation. J Vet Intern Med 2009;23:631-635.
- Mazan MR, Merriam JG. Perspectives in Professional Education "A Description of the Tufts Cummings School of Veterinary Medicine" Massachusetts Equine Clinic Combined Equine Medicine Internship Program. JAVMA 2009, 235: 38-40.
- Mazan MR, Svatek J, Maranda L, Christiani D, Ghio A, Nadeau J, Hoffman AM. Questionnaire assessment of airway disease symptoms in equine barn personnel. Occup Med 2009;59(4):220-225.
- Ceresia ML, Fasser CE, Rush JE, Scheife RT, Orcutt CJ, Michalski DL,Mazan MR, Dorsey MT, Bernardi SP. The role and education of the veterinary pharmacist. Am J Pharm Educ. 2009;19:73:16.
- Nolen-Walston RD, Boston RC, Wilkins PA, Mazan MR, Kuehn H, Hoffman AM. Reproducibility of airway responsiveness using flowmetric plethysmography and histamine bronchoprovocation in horses. J Vet Int Med 2009:23;631-635.
General Research Interests
- The equine respiratory system: Pathophysiology of small airway inflammatory disease - airway smooth muscle
- Effects of particulate matter air pollution on equine respiratory disease
- Resting energy in horses with recurrent airway obstruction
- Non-invasive lung function testing
- Stem cell applications in equine internal medicine
- Role of the trophic macrophage in lung regeneration
- Director of TCSVM/Massachusetts Equine Clinic Large Animal Medicine Internship
- Equine sports medicine, equine exercise physiology, respiratory pathophysiology
Research Interests by Area
- Stem cell applications for respiratory disease and systemic inflammation.
Spontaneous Animal Disease Models
- Airway disease in horses, COPD, regenerative medicine
Research Interests by Organ System and Disease
- Dynamics of bronchioalveolar stem cell response to sublethal hyperoxia and recovery in mice. Respiratory: Role of the macrophage; environmental respiratory disease (animal models); stem cell applications