Anesthesia, Pain Pharmacogenetics
Lois Wetmore, DVM, MS, ScD, DACVAA, Faculty member in the Anesthesia and Analgesia service at Cummings School of Veterinary Medicine and is a diplomate in the American College of Veterinary Anesthesia and Analgesia. She graduated from Colorado State University Veterinary School in 1982 and did her residency training at Michigan State University where she also earned a MS degree in Veterinary Sciences. Dr Wetmore continued her research training at Harvard’s T.H. Chan School of Public Health where she received a doctoral degree in 1993. Dr. Wetmore has been a member of the Cummings faculty for the last 25 years where she focuses on teaching DVM students in didactic courses and clinical rotations, providing anesthesia service to the large and small animal hospitals, and doing research studying genetic-related differences in how companion animals respond to analgesia drugs.
- SD - Harvard T.H. Chan School of Public Health - 1993
- MS - Michigan State University - 1987
- DVM - Colorado State University - 1982
- BS - Utah State University - 1977
- American College of Veterinary Anesthesia and Analgesia (ACVAA)
- Wetmore, L.A., Pascoe, P.J., Shilo-Benjamini, Y., Lindsey, J.C. 2016. Effects of fentanyl administration on locomotor response in horses with the G57C µ-opioid receptor polymorphism. American Journal of Veterinary Research.
- Krein, S.R., Lindsey, J.C., Blaze, C.A., Wetmore, L.A. 2014. Evaluation of risk factors, including fluconazole administration, for prolonged anesthetic recovery times in horses undergoing general anesthesia for ocular surgery: 81 cases (2006-2013). Journal of the American Veterinary Medical Association.
- Carvalho, K.N., Rush, J.E., Wetmore, L.A. 2014. ECG of the month. Journal of the American Veterinary Medical Association.
- Abelson, A.L., Armitage-Chan, E., Lindsey, J.C., Wetmore, L.A. 2011. A comparison of epidural morphine with low dose bupivacaine versus epidural morphine alone on motor and respiratory function in dogs following splenectomy. Veterinary Anaesthesia and Analgesia.
- Hawley, A.T., Wetmore, L.A. 2010. Identification of single nucleotide polymorphisms within exon 1 of the canine mu-opioid receptor gene. Veterinary Anaesthesia and Analgesia.
- Abelson, A.L., McCobb, E.C., Shaw, S., Armitage-Chan, E., Wetmore, L.A., Karas, A.Z., Blaze, C. 2009. Use of wound soaker catheters for the administration of local anesthetic for post-operative analgesia: 56 cases. Veterinary Anaesthesia and Analgesia.
- Armitage-Chan, E.A., Wetmore, L.A., Chan, D.L. 2007. Anesthetic management of the head trauma patient: State of the art review. Journal of Veterinary Emergency and Critical Care.
- Armitage, E.A., Wetmore, L.A., Chan, D.L., Lindsey, J.C. 2005. Evaluation of compliance among nursing staff in administration of prescribed analgesic drugs to critically ill dogs and cats. Journal of the American Veterinary Medical Association.
- Levensaler, A.R., Wetmore, L.A. 2004. The ins and outs of anesthesia machines. Veterinary Technician.
- Wetmore, L.A., Glowaski, M.M. 2000. Epidural analgesia in veterinary critical care. Clinical techniques in small animal practice.
- Garrod, L.A., Wetmore, L. 1999. Anesthetic Agents in Trauma Patients. Compendium on Continuing Education for the Practicing Veterinarian.
- Glowaski, M.M., Wetmore, L.A. 1999. Propofol: application in veterinary sedation and anesthesia.. Clinical techniques in small animal practice.
- Gray, P.R., Lowrie, C.T., Wetmore, L.A. 1987. Effect of intravenous administration of dextrose or lactated Ringer's solution on seizure development in dogs after cervical myelography with metrizamide. American Journal of Veterinary Research.
- Wetmore, L.A., Derksen, F.J., Blaze, C.A., Eyster, G.E. 1987. Mixed venous oxygen tension as an estimate of cardiac output in anesthetized horses.. American Journal of Veterinary Research.
General Research Interests
- Molecular characterization of receptors involved in the transmission and treatment of pain. Unique species specific aspects of opioid receptors.
Research and Clinical Interests
- Effects of anesthetic drugs on the incidence of perioperative gastroesophageal reflux (GER) and regurgitation
- Polymorphisms in opioid receptors
- MDR1 mutations and their effects on oral morphine absorption from GI tract
- Cytochrome P450 polymorphisms and metabolism of NSAIDs in dogs
Research Interests by Area
Pain Management and Alternatives
- Molecular characterization of receptors involved in the transmission and treatment of pain, unique species aspects of opioid receptors. Clinical anesthesiology; genetic basis of anesthetic responses