Cummings School of Veterinary Medicine at Tufts University
Elizabeth McNiel

Oncology

Affiliations

Specialties

Education

  • PhD (Radiation Biology) - Colorado State University - 2000
  • DVM - Texas A&M University - 1992
  • BS - University of Texas - Austin - 1988

Board Certification

  • ACVIM - Oncology
  • ACVR - Radiation Oncology

NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells

Author(s):Kottakis, F. | Foltopoulou, P. | Sanidas, I. | Keller, P. | Wronski, A. | Dake, B.T. | Ezell, S.A. | Shen, Z. | Naber, S.P. | Hinds, P.W. | McNiel, E. | Kuperwasser, C. | Tsichlis, P.N.
Publication year: 2014
Journal / Book title: Cancer Research

Abdominal ultrasonographic findings at diagnosis of osteosarcoma in dogs and association with treatment outcome

Author(s):Sacornrattana, O. | Dervisis, N.G. | Mcniel, E.A.
Publication year: 2013
Journal / Book title: Veterinary and Comparative Oncology

Evaluation of hypoxia in a feline model of head and neck cancer using 64Cu-ATSM positron emission tomography/computed tomography

Author(s):Ballegeer, E.A. | Madrill, N.J. | Berger, K.L. | Agnew, D.W. | McNiel, E.A.
Publication year: 2013
Journal / Book title: BMC Cancer

Conservation of avian germplasm by xenogeneic transplantation of spermatogonia from sexually mature donors

Author(s):Pereira, R.J.G. | Napolitano, A. | Garcia-Pereira, F.L. | Baldo, C.F. | Suhr, S.T. | King, L.E. | Cibelli, J.B. | Karcher, D.M. | McNiel, E.A. | Perez, G.I.
Publication year: 2013
Journal / Book title: Stem Cells and Development

Use of propofol for induction of anesthesia in dogs undergoing definitive radiation therapy: 31 cases (2006-2009)

Author(s):Erfourth, T.M. | McNiel, E.A. | Scott, M.A. | Wilson, D.V.
Publication year: 2012
Journal / Book title: Journal of the American Veterinary Medical Association

Use of three-dimensional conformal radiation therapy for treatment of a heart base chemodectoma in a dog

Author(s):Rancilio, N.J. | Higuchi Dr., T. | Gagnon Dr., J. | McNiel, E.A.
Publication year: 2012
Journal / Book title: Journal of the American Veterinary Medical Association

A Randomized Trial Investigating the Efficacy and Safety of Water Soluble Micellar Paclitaxel (Paccal Vet) for Treatment of Nonresectable Grade 2 or 3 Mast Cell Tumors in Dogs

Author(s):Vail, D.M. | von Euler, H. | Rusk, A.W. | Barber, L. | Clifford, C. | Elmslie, R. | Fulton, L. | Hirschberger, J. | Klein, M. | London, C. | Martano, M. | McNiel, E.A. | Morris, J.S. | Northrup, N. | Phillips, B. | Polton, G. | Post, G. | Rosenberg, M. | Ruslander, D. | Sahora, A. | Siegel, S. | Thamm, D. | Westberg, S. | Winter, J. | Khanna, C.
Publication year: 2012
Journal / Book title: Journal of Veterinary Internal Medicine

Initial evaluation of safety of wide-field irradiation in the treatment of hematopoietic neoplasia in the cat

Author(s):Husbands, B.D. | Mcniel, E.A. | Modiano, J.F.
Publication year: 2010
Journal / Book title: Veterinary Radiology and Ultrasound

Evaluation of Microsatellite Instability in Urine for the Diagnosis of Transitional Cell Carcinoma of the Lower Urinary Tract in Dogs

Author(s):Sotirakopoulos, A.J. | Armstrong, P.J. | Heath, L. | Madrill, N.J. | McNiel, E.A.
Publication year: 2010
Journal / Book title: Journal of Veterinary Internal Medicine

Treatment of an amelanotic melanoma using radiation therapy in a lesser madagascar hedgehog tenrec (Echinops telfairi)

Author(s):Harrison, T.M. | Dominguez, P. | Hanzlik, K. | Sikarskie, J.G. | Agnew, D. | Bergin, I. | Fitzgerald, S.D. | Kitchell, B.E. | McNiel, E.
Publication year: 2010
Journal / Book title: Journal of Zoo and Wildlife Medicine

NOD/SCID mouse model of canine T-cell lymphoma with humoral hypercalcaemia of malignancy: Cytokine gene expression profiling and in vivo bioluminescent imaging

Author(s):Nadella, M.V.P. | Kisseberth, W.C. | Nadella, K.S. | Thudi, N.K. | Thamm, D.H. | Mcniel, E.A. | Yilmaz, A. | Boris-Lawrie, K. | Rosol, T.J.
Publication year: 2008
Journal / Book title: Veterinary and Comparative Oncology

Pericardial disorders and cardiac tumors

Author(s):Tobias, A.H. | McNiel, E.A.
Publication year: 2008
Journal / Book title: Manual of Canine and Feline Cardiology

Intracranial glioblastoma models in preclinical neuro-oncology: Neuropathological characterization and tumor progression

Author(s):Candolfi, M. | Curtin, J.F. | Nichols, W.S. | Muhammad, A.K.M.G. | King, G.D. | Pluhar, G.E. | McNiel, E.A. | Ohlfest, J.R. | Freese, A.B. | Moore, P.F. | Lerner, J. | Lowenstein, P.R. | Castro, M.G.
Publication year: 2007
Journal / Book title: Journal of Neuro-Oncology

Microsatellite instability in canine mammary gland tumors

Author(s):McNiel, E.A. | Griffin, K.L. | Mellett, A.M. | Madrill, N.J. | Mickelson, J.R.
Publication year: 2007
Journal / Book title: Journal of Veterinary Internal Medicine

Scheduling of radiation with angiogenesis inhibitors anginex and avastin improves therapeutic outcome via vessel normalization

Author(s):Dings, R.P.M. | Loren, M. | Heun, H. | McNiel, E. | Griffioen, A.W. | Mayo, K.H. | Griffin, R.J.
Publication year: 2007
Journal / Book title: Clinical Cancer Research

Urinary biomarkers to assess exposure of cats to environmental tobacco smoke

Author(s):McNiel, E.A. | Carmella, S.G. | Health, L.A. | Bliss, R.L. | Le, K.-A. | Hecht, S.S.
Publication year: 2007
Journal / Book title: American Journal of Veterinary Research

Adenoviral-mediated gene transferinto the canine brain in vivo

Author(s):Candolfi, M. | Kroeger, K.M. | Pluhar, G.E. | Bergeron, J. | Puntel, M. | Curtin, J.F. | McNiel, E.A. | Freese, A.B. | Ohlfest, J.R. | Moore, P. | Lowenstein, P.R. | Castro, M.G.
Publication year: 2007
Journal / Book title: Neurosurgery

Comparison of cytogenetics and polymerase chain reaction based detection of the amelogenin gene polymorphism for the diagnosis of freemartinism in cattle

Author(s):McNiel, E.A. | Madrill, N.J. | Treeful, A.E. | Buoen, L.C. | Weber, A.F.
Publication year: 2006
Journal / Book title: Journal of Veterinary Diagnostic Investigation

Evaluation of factors associated with survival in dogs with untreated nasal carcinomas: 139 Cases (1993-2003)

Author(s):Rassnick, K.M. | Goldkamp, C.E. | Erb, H.N. | Scrivani, P.V. | Njaa, B.L. | Gieger, T.L. | Turek, M.M. | McNiel, E.A. | Proulx, D.R. | Chun, R. | Mauldin, G.E. | Phillips, B.S. | Kristal, O.
Publication year: 2006
Journal / Book title: Journal of the American Veterinary Medical Association

Establishment of an immortalized cell line and transplantable xenograft from a bronchioloalveolar lung carcinoma of a cat

Author(s):Grossman, D.A. | McNiel, E.A. | Hackett, T.B. | Barsky, S.H.
Publication year: 2002
Journal / Book title: American Journal of Veterinary Research

General Research Interests

Cancers occurring in pet animals are common and share morphology, biologic behavior and many molecular features with human cancers. Therefore cancers in pet animals provide a potentially useful means to understand cancers in all species. My roles as a both veterinary clinician and scientist facilitate the combination of molecular and cellular biologic techniques with veterinary clinical investigations. The overarching goals of this research are 1) to improve the ability to prevent, detect, and treat cancer and 2) to develop new animal models for translational cancer research. 

Selected Research Projects

  • Effects of anti-angiogenic therapy in feline oral squamous cell carcinoma.
  • Investigating canine hereditary Gastric carcinoma susceptibility.
  • DNA Mismatch repair in the biology of  bladder cancer.
  • Role of aluminum in feline vaccine-associated carcinogenesis.

Research Interests by Area

Spontaneous Animal Disease Models
  • Lymphoma, osteosarcoma, transitional cell carcinoma, prostatic cancer, hemangiosarcoma, mammary (breast) cancer, squamous cell carcinoma in cats

Research Interests by Organ System and Disease

Oncology and Cancer Research and Clinical Trials
  • Companion animals in translational cancer research, Chromatin Modification in Canine Cancer. Biological mechanisms of cancer; spontaneous animal disease models; radiation oncology.