Cummings School of Veterinary Medicine at Tufts University
Daniela Bedenice

Respiratory Physiology, Large Animal Medicine

A leading expert on llamas, alpacas and other camelid species, Dr.Daniela Bedenice brings a wonderful range of expertise to the Hospital for Large Animals. In addition to her camelid care, Dr. Bedenice takes great pride in her work with foals and adult horses.

Dr. Bedenice grew up in rural Germany, where she trained and cared for many horses, and even accompanied her local veterinarian on nearly two years' worth of farm calls. I guess I was hooked, she says. After earning her veterinary degree from the Free University of Berlin,Dr. Bedenice undertook a residency with a private practice. Soon after, she moved to the United States, earned her board certification in both veterinary internal medicine and emergency and critical care, and joined the faculty at the Cummings School.

Dr. Bedenice was drawn to The Hospital for Large Animals because it offered a unique environment of collegiality, mentorship, intellectual wealth and professional challenge, all of which presented the opportunity to make a significant contribution to the veterinary profession.

As an Assistant Professor in the Department of Clinical Sciences at the Cummings School of Veterinary Medicine,Dr. Bedenice leads and contributes to a variety of courses and clinics, including large animal internal medicine, gastro-intestinal disease and neurology, camelid medicine, gastro-intestinal pathophysiology, neuro-pathophysiology, toxicology, clinical pharmacology. She also serves as a facilitator for the Problem-Based Learning course. The greatest honor is to observe the professional growth and enthusiasm of those you had the pleasure of teaching, she says.

Education

  • Dr. med. vet. - Free University of Berlin, Germany - 1997

Board Certification

  • Diplomate ACVIM (Large Animal) - 2002
  • Diplomate ACVECC (Equine) - 2005

A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2.

Author(s):Tremblay, J.M. | Mukherjee, J. | Leysath, C.E. | Debatis, M. | Ofori, K. | Baldwin, K. | Boucher, C. | Peters, R. | Beamer, G. | Sheoran, A. | Bedenice, D. | Tzipori, S. | Shoemaker, C.B.
Publication year: 2013
Journal / Book title: Infection and immunity

Sequential L-lactate concentration in hospitalised equine neonates: A prospective multicentre study

Author(s):Borchers, A. | Wilkins, P.A. | Marsh, P.M. | Axon, J.E. | Read, J. | Castagnetti, C. | Pantaleon, L. | Clark, C. | Qura'n, L. | Belgrave, R. | Schwarzwald, C. | Levy, M. | Bedenice, D. | Saulez, M.N. | Boston, R.C.
Publication year: 2013
Journal / Book title: Equine Veterinary Journal

Prevalence of mycobacterium avium subsp. paratuberculosis fecal shedding in alpacas presented to veterinary hospitals in the United States

Author(s):Fecteau, M.-E. | Bedenice, D. | Cebra, C.K. | Pinn, T.L. | Mcadams, S.C. | Fyock, T.L. | Whitlock, R.H. | Sweeney, R.W.
Publication year: 2013
Journal / Book title: Journal of Veterinary Internal Medicine

Systemic Distribution of Viral Antigen in Alpacas Persistently Infected With Bovine Pestivirus

Author(s):Henningson, J.N. | Steffen, D.J. | Topliff, C.L. | Kurth, K.L. | Dubielzig, R.R. | Brodersen, B.W. | Bedenice, D. | Eskridge, K.M. | Callan, R.J. | Reggiardo, C. | Rupp, G.P. | Kelling, C.L.
Publication year: 2013
Journal / Book title: Veterinary Pathology

Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection

Author(s):Holmes, K. | Bedenice, D. | Papich, M.G.
Publication year: 2012
Journal / Book title: Journal of Veterinary Pharmacology and Therapeutics

Low tidal volume ventilation in healthy dogs

Author(s):Oura, T. | Rozanski, E.A. | Buckley, G. | Bedenice, D.
Publication year: 2012
Journal / Book title: Journal of Veterinary Emergency and Critical Care

Association of admission L-lactate concentration in hospitalised equine neonates with presenting complaint, periparturient events, clinical diagnosis and outcome: a prospective multicentre study.

Author(s):Borchers, A. | Wilkins, P.A. | Marsh, P.M. | Axon, J.E. | Read, J. | Castagnetti, C. | Pantaleon, L. | Clark, C. | Qura'n, L. | Belgrave, R. | Trachsel, D. | Levy, M. | Bedenice, D. | Saulez, M.N. | Boston, R.C.
Publication year: 2012
Journal / Book title: Equine veterinary journal. Supplement

Association of admission L-lactate concentration in hospitalised equine neonates with presenting complaint, periparturient events, clinical diagnosis and outcome: A prospective multicentre study

Author(s):Borchers, A. | Wilkins, P.A. | Marsh, P.M. | Axon, J.E. | Read, J. | Castagnetti, C. | Pantaleon, L. | Clark, C. | Qura'n, L. | Belgrave, R. | Trachsel, D. | Levy, M. | Bedenice, D. | Saulez, M.N. | Boston, R.C.
Publication year: 2012
Journal / Book title: Equine Veterinary Journal

A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model

Author(s):Mukherjee, J. | Tremblay, J.M. | Leysath, C.E. | Ofori, K. | Baldwin, K. | Feng, X. | Bedenice, D. | Webb, R.P. | Wright, P.M. | Smith, L.A. | Tzipori, S. | Shoemaker, C.B.
Publication year: 2012
Journal / Book title: PLoS ONE

Respiratory mechanics and results of cytologic examination of bronchoalveolar lavage fluid in healthy adult alpacas

Author(s):Pacheco, A.P. | Bedenice, D. | Mazan, M.R. | Hoffman, A.M.
Publication year: 2012
Journal / Book title: American Journal of Veterinary Research

Measurement of corneal sensitivity in 20 ophthalmologically normal alpacas

Author(s):Welihozkiy, A. | Bedenice, D. | Price, L.L. | Pizzirani, S. | Pirie, C.G.
Publication year: 2011
Journal / Book title: Veterinary Ophthalmology

Retrospective evaluation of parenteral nutrition in alpacas: 22 cases (2002-2008)

Author(s):Clore, E.R.S. | Freeman, L.M. | Bedenice, D. | Tony Buffington, C.A. | Anderson, D.E.
Publication year: 2011
Journal / Book title: Journal of Veterinary Internal Medicine

Long-term clinicopathological characteristics of alpacas naturally infected with bovine viral diarrhea virus type Ib

Author(s):Bedenice, D. | Dubovi, E. | Kelling, C.L. | Henningson, J.N. | Topliff, C.L. | Parry, N.
Publication year: 2011
Journal / Book title: Journal of Veterinary Internal Medicine

The effect of body position, sedation, and thoracic bandaging on functional residual capacity in healthy deep-chested dogs

Author(s):Rozanski, E.A. | Bedenice, D. | Lofgren, J. | Abrams, J. | Bach, J. | Hoffman, A.M.
Publication year: 2010
Journal / Book title: Canadian Journal of Veterinary Research

Cardiopulmonary effects of dobutamine and norepinephrine infusion in healthy anesthetized alpacas

Author(s):Vincent, C.J. | Hawley, A.T. | Rozanski, E.A. | Lascola, K.M. | Bedenice, D.
Publication year: 2009
Journal / Book title: American Journal of Veterinary Research

Neurologic Diseases in Llamas and Alpacas

Author(s):Whitehead, C.E. | Bedenice, D.
Publication year: 2009
Journal / Book title: Veterinary Clinics of North America - Food Animal Practice

Approach to the Critically Ill Camelid

Author(s):Bedenice, D.
Publication year: 2009
Journal / Book title: Veterinary Clinics of North America - Food Animal Practice

Genotyping and phylogenetic analysis of bovine viral diarrhea virus isolates from BVDV infected alpacas in North America

Author(s):Kim, S.G. | Anderson, R.R. | Yu, J.Z. | Zylich, N.C. | Kinde, H. | Carman, S. | Bedenice, D. | Dubovi, E.J.
Publication year: 2009
Journal / Book title: Veterinary Microbiology

Concurrent Infection with Anaplasma phagocytophilum and Mycoplasma haemolamae in a young alpaca

Author(s):Lascola, K. | Vandis, M. | Bain, P. | Bedenice, D.
Publication year: 2009
Journal / Book title: Journal of Veterinary Internal Medicine

Humoral response to an equine encephalitis vaccine in healthy alpacas

Author(s):Bedenice, D. | Bright, A. | Pedersen, D.D. | Dibb, J.
Publication year: 2009
Journal / Book title: Journal of the American Veterinary Medical Association

General Research Interests

Comparative respiratory physiology and non-invasive pulmonary function testing (equine, canine, camelid). Large animal neonatal and adult critical care. Emerging infectious diseases in camelids.

Selected Research Projects

  • Characterization of immune responses in juvenile alpacas persistently infected with BVDV. Alpaca Research Foundation (ARF).
  • The cardiovascular effects of dobutamine infusion in healthy, adult, anesthetized alpacas. Empire Alpaca Association.
  • The humoral response to EEE vaccination in healthy alpacas. (ARF).
  • Non-invasive measurement of respiratory resistance (Rrs) using two different oscillatory methods in the horse: Comparative study of impulse oscillometry (IOS) and Monofrequency Forced Oscillatory Mechanics (FOM) in the adult horse, pre and post bronchodilation.
  • Non-invasive measurement of airway resistance (Raw) and functional residual capacity (FRC) in conscious sheep and dogs.
  • Respiratory mechanics in awake adult llamas.

Research Interests by Area

Other Areas of Research
  • Humoral response to vaccination
Regenerative Medicine
  • Regenerative medicine in camelids.
Spontaneous Animal Disease Models
  • Respiratory disease in large animals, COPD, parasitic lung disease

Research Interests by Organ System and Disease

Respiratory Diseases
  • Comparative respiratory physiology and non-invasive pulmonary function testing (equine,canine,camelid). Respiratory disease in horses and alpacas, clinical pharmacology

Major Specialized Equipment

Pulmonary Mechanics Data Acquisition System - XA BioSystem ; Whole Body Plethysmograph ; Canine (Head-Out) Plethysmograph; small Canine Whole Body (unrestrained) Plethysmograph (measurement of PENH); inductance plethysmography (Respitrace ) for measurements of abdominal and rib cage ventilation and thoracoabdominal synchrony; Helium and Carbon Monoxide Monitor (Morgan Scientific - measurement of diffusion capacity of CO and helium dilution using rebreathing, steady state, or single breath method); ventilators; Indirect Calorimeter (Vmax, ViaSys) - resting and exercise energy (VO2, VCO2, RQ), Sato High Speed Treadmill for exercise studies in horses, sheep, dogs, etc.; patient monitoring system (Passport II ), Arterial Blood Gas Analyzer; Computed Tomography (Pickard 5000 Spiral CT and densitometry software); video endoscopy/gastroscopy etc. Clinical pathology, pathology, ultrasound and radiology facilities complement the environment.