Cummings School of Veterinary Medicine at Tufts University
Daniela Bedenice

Respiratory Physiology, Large Animal Medicine

A leading expert on llamas, alpacas and other camelid species, Dr.Daniela Bedenice brings a wonderful range of expertise to the Hospital for Large Animals. In addition to her camelid care, Dr. Bedenice takes great pride in her work with foals and adult horses.

Dr. Bedenice grew up in rural Germany, where she trained and cared for many horses, and even accompanied her local veterinarian on nearly two years' worth of farm calls. I guess I was hooked, she says. After earning her veterinary degree from the Free University of Berlin,Dr. Bedenice undertook a residency with a private practice. Soon after, she moved to the United States, earned her board certification in both veterinary internal medicine and emergency and critical care, and joined the faculty at the Cummings School.

Dr. Bedenice was drawn to The Hospital for Large Animals because it offered a unique environment of collegiality, mentorship, intellectual wealth and professional challenge, all of which presented the opportunity to make a significant contribution to the veterinary profession.

As an Assistant Professor in the Department of Clinical Sciences at the Cummings School of Veterinary Medicine,Dr. Bedenice leads and contributes to a variety of courses and clinics, including large animal internal medicine, gastro-intestinal disease and neurology, camelid medicine, gastro-intestinal pathophysiology, neuro-pathophysiology, toxicology, clinical pharmacology. She also serves as a facilitator for the Problem-Based Learning course. The greatest honor is to observe the professional growth and enthusiasm of those you had the pleasure of teaching, she says.

Education

  • Dr. med. vet. - Free University of Berlin, Germany - 1997

Board Certification

  • Diplomate ACVIM (Large Animal) - 2002
  • Diplomate ACVECC (Equine) - 2005
  1. Mukherjee J, Tremblay JM, Leysath CE, Ofori K, Baldwin K, Feng X, Bedenice D, Webb RP, Wright PM, Smith LA, Tzipori S, Shoemaker CB. A novel strategy for development of recombinant antitoxin therapeutics tested in a mouse botulism model. PLoS One 2012; 7(1): eEpub 2012 Jan 6.
  2. Borchers A, Wilkins PA, Marsh PM, Axon JE, Read J, Castagnetti C, Pantaleon L, Clark C, Qura'n L, Belgrave R, Trachsel D, Levy M, Bedenice D, Saulez MN, Boston RC. Association of admission L-lactate concentration in hospitalised equine neonates with presenting complaint, periparturient events, clinical diagnosis and outcome: a prospective multicentre study. Equine Vet J Suppl 2012; 41:57-63.
  3. Holmes K, Bedenice D, Papich MG. Florfenicol pharmacokinetics in healthy adult alpacas after subcutaneous and intramuscular injection. J Vet Pharmacol Ther 2011; Epub ahead of print.
  4. Pacheco A, Bedenice D, Mazan M, Hoffman AM. Respiratory mechanics and bronchoalveolar lavage in healthy adult alpacas. Am J Vet Res 2011; 73(1):146-52.
  5. Welihozkiy A, Bedenice D, Price LL, Pizzirani S, Pirie CG. Measurement of cornea sensitivity in 20 ophthalmologically normal alpacas. Vet. Ophthalmology 2011; 14(5):333-6.
  6. Clore E, Freeman LM, Bedenice D, Buffington T, Anderson DE. Retrospective evaluation of total parenteral nutrition in alpacas: 22 cases (2002-2008). J Vet Intern Med 2011; 25(3):598-604.
  7. Bedenice D, Dubovi E, Kelling CL, Henningson JN, Topliff CL, Parry N.. Long-term clinico-pathological characteristics of alpacas naturally infected with Bovine Viral Diarrhea Virus type Ib. J Vet Intern Med 2011; 25(3):605-12.
  8. Rozanski EA, Bedenice D, Lofgren J, Abrams J, Bach J, Hoffman AM. The effect of body position, sedation, and thoracic bandaging on functional residual capacity in healthy deep-chested dogs. Can J Vet Res 2010; 74(1):34-9.
  9. Vincent CJ, Hawley AT, Rozanski EA, Lascola KM, Bedenice D. Cardiopulmonary effects of dobutamine and norepinephrine infusion in healthy anesthetized alpacas. Am J Vet Res 2009; 70(10):1236-42.
  10. Bedenice D. Approach to the critically ill camelid. Vet Clin North Am Food Anim Pract 2009;25(2):407-21.
  11. Whitehead CE, Bedenice D. Neurologic diseases in llamas and alpacas. Vet Clin North Am Food Anim Pract 2009; 25(2):385-405.
  12. Bedenice D, Bright A, Pedersen DD, Dibb J. Humoral response to an equine encephalitis vaccine in healthy alpacas. J Am Vet Med Assoc 2009; 234(4):530-4.
  13. Topliff CL, Smith DR, Clowser SL, Steffen DJ, Henningson JN, Brodersen BW, Bedenice D, Callan RJ, Reggiardo C, Kurth KL, Kelling CL. Prevalence of bovine viral diarrhea virus infections in alpacas in the United States. J Am Vet Med Assoc 2009; 234(4):519-29.
  14. Lascola K, Vandis M, Bain P, Bedenice D. Concurrent Infection with Anaplasma phagocytophilum and Mycoplasma haemolamae in a young alpaca. J Vet Intern Med 2009; 23(2):379-82.
  15. Kim SG, Anderson RR, Yu JZ, Zylich NC, Kinde H, Carman S, Bedenice D, Dubovi EJ. Genotyping and phylogenetic analysis of bovine viral diarrhea virus isolates from BVDV infected alpacas in North America. Vet Microbiol 2009; 136(3-4):209-16.
  16. Paxson JA, Cunningham S, Rush J, Bedenice D. The association of lung function and plasma volume expansion in neonatal alpaca crias following plasma transfusion for failure of passive transfer. J Vet Emerg Crit Care 2008; 18(6):601-607.
  17. Bedenice D, Mazan MR, Hoffman AM. Association between cough and cytology of bronchoalveolar lavage fluid and pulmonary function in horses diagnosed with inflammatory airway disease. J Vet Intern Med 2008; 22(4):1022-8.
  18. Nolen-Walston R, Bedenice D, Rodriguez C, Rushton S, Bright A, Fecteau ME, et al. Eastern equine encephalitis in 9 South American camelids. J Vet Intern Med 2007; 21(4):846-52.
  19. Bedenice D. Evidence-based medicine in equine critical care. Vet Clin North Am Equine Pract 2007; 23(2):293-316.
  20. Wilkins PA, Otto CM, Baumgardner JE, Dunkel B, Bedenice D, Paradis MR, Staffieri F, Syring RS, Slack J, Grasso S, Pranzo G. Acute lung injury and acute respiratory distress syndromes in veterinary medicine: consensus definitions: The Dorothy Russell Havemeyer Working Group on ALI and ARDS in Veterinary Medicine, J Vet Emerg Crit Care 2007: 17(4) 333-339.
  21. Lascola KM, Hoffman AM, Mazan MR, Bedenice D. Respiratory mechanics in sedated and nonsedated adult llamas. Am J Vet Res 2007; 68(6):676-84.
  22. Bach JF, Rozanski EA, Bedenice D, Chan DL, Freeman LM, Lofgren JL, et al. Association of expiratory airway dysfunction with marked obesity in healthy adult dogs. Am J Vet Res 2007; 68(6):670-5.

General Research Interests

Comparative respiratory physiology and non-invasive pulmonary function testing (equine, canine, camelid). Large animal neonatal and adult critical care. Emerging infectious diseases in camelids.

Selected Research Projects

  • Characterization of immune responses in juvenile alpacas persistently infected with BVDV. Alpaca Research Foundation (ARF).
  • The cardiovascular effects of dobutamine infusion in healthy, adult, anesthetized alpacas. Empire Alpaca Association.
  • The humoral response to EEE vaccination in healthy alpacas. (ARF).
  • Non-invasive measurement of respiratory resistance (Rrs) using two different oscillatory methods in the horse: Comparative study of impulse oscillometry (IOS) and Monofrequency Forced Oscillatory Mechanics (FOM) in the adult horse, pre and post bronchodilation.
  • Non-invasive measurement of airway resistance (Raw) and functional residual capacity (FRC) in conscious sheep and dogs.
  • Respiratory mechanics in awake adult llamas.

Research Interests by Area

Other Areas of Research
  • Humoral response to vaccination
Regenerative Medicine
  • Regenerative medicine in camelids.
Spontaneous Animal Disease Models
  • Respiratory disease in large animals, COPD, parasitic lung disease

Research Interests by Organ System and Disease

Respiratory Diseases
  • Comparative respiratory physiology and non-invasive pulmonary function testing (equine,canine,camelid). Respiratory disease in horses and alpacas, clinical pharmacology

Major Specialized Equipment

Pulmonary Mechanics Data Acquisition System - XA BioSystem ; Whole Body Plethysmograph ; Canine (Head-Out) Plethysmograph; small Canine Whole Body (unrestrained) Plethysmograph (measurement of PENH); inductance plethysmography (Respitrace ) for measurements of abdominal and rib cage ventilation and thoracoabdominal synchrony; Helium and Carbon Monoxide Monitor (Morgan Scientific - measurement of diffusion capacity of CO and helium dilution using rebreathing, steady state, or single breath method); ventilators; Indirect Calorimeter (Vmax, ViaSys) - resting and exercise energy (VO2, VCO2, RQ), Sato High Speed Treadmill for exercise studies in horses, sheep, dogs, etc.; patient monitoring system (Passport II ), Arterial Blood Gas Analyzer; Computed Tomography (Pickard 5000 Spiral CT and densitometry software); video endoscopy/gastroscopy etc. Clinical pathology, pathology, ultrasound and radiology facilities complement the environment.