Cynthia R. L. Webster - DVM, DACVIM

Cynthia R. L. Webster
Associate Chair; Small Animal Medicine

Dr.Cynthia Webster is an expert in canine and feline liver disease and a board-certified small animal medicine internist. At the Cummings School, she leads the veterinary Liver Study Group, an umbrella organization of the Comparative Gastroenterology Society. Her research interests include how the liver regulates its ability to survive after toxic insults, especially during times when bile flow is attenuated.

Dr.Webster grew up in a small town in western Massachusetts. She says she was drawn to comparative medicine so that she could one day not only care for dogs and cats, but also solve problems in human medicine. After attending Cornell University's veterinary school and doing post-graduate work in liver disease at Tufts University School of Medicine,Dr.Webster now has a joint appointment that allows her to do just that: she teaches gastrointestinal and liver pharmacology, pathology and medicine toDVMstudents at the Cummings School and lectures graduate students at Tufts Sackler School in Boston.

It is hard to not be a great doctor in this environment,Dr.Webster says of the Cummings School.At the Foster Hospital for Small Animals, you have so many brilliant minds to work with and experts in every discipline. I love being able to do biomedical research one day, work with owners and their pets the next, and through it all still have the ability to train the next generation of veterinarians.

Dr.Webster lives in Grafton with her husband and son. She is active in the Grafton public schools and organizes Tufts' outreach efforts—ranging from science lectures to career days. She admits to being a cat lady and has two cats at home she adores.

Education

  • DVM - Cornell University - 1985
  • BS - Simmons College - 1978

House Officer Training

  • ACVIM Small Animal Medicine - TCSVM

Board Certification

  • Diplomate, American College of Veterinary Internal Medicine (Small Animal)
  1. Webster, C.R.L. 2017. Hemostatic Disorders Associated with Hepatobiliary Disease. Veterinary Clinics of North America - Small Animal Practice.
  2. Fry, W., Lester, C., Etedali, N.M., Shaw, S., DeLaforcade, A., Webster, C.R.L. 2017. Thromboelastography in Dogs with Chronic Hepatopathies. Journal of Veterinary Internal Medicine.
  3. Daure, E., Ross, L., Webster, C.R.L. 2017. Gastroduodenal ulceration in small animals: Part 1. Pathophysiology and epidemiology. Journal of the American Animal Hospital Association.
  4. Daure, E., Ross, L., Webster, C.R.L. 2017. Gastroduodenal ulceration in small animals: Part 2. Proton pump inhibitors and histamine-2 receptor antagonists. Journal of the American Animal Hospital Association.
  5. Buckley, F.I., Mahony, O., Webster, C.R.L. 2017. Adrenal function in cats with cholestatic liver disease. Journal of Veterinary Diagnostic Investigation.
  6. Lester, C., Cooper, J., Peters, R.M., Webster, C.R. 2016. Retrospective evaluation of acute liver failure in dogs (1995-2012): 49 cases. Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
  7. Schonhoff, C.M., Park, S.W., Webster, C.R.L., Anwer, M.S. 2016. p38 MAPK α and β isoforms differentially regulate plasma membrane localization of MRP2. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  8. Webster, C.R.L., Anwer, M.S. 2016. Hydrophobic bile acid apoptosis is regulated by sphingosine-1-phosphate receptor 2 in rat hepatocytes and human hepatocellular carcinoma cells. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  9. Kelley, D., Lester, C., Shaw, S., de Laforcade, A., Webster, C.R.L. 2015. Thromboelastographic evaluation of dogs with acute liver disease. Journal of Veterinary Internal Medicine.
  10. Webster, C.R.L., Johnston, A.N., Sawkat Anwer, M. 2014. Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  11. Tucker, S., Penninck, D.G., Keating, J.H., Webster, C.R. 2014. Clinicopathological and ultrasonographic features of cats with eosinophilic enteritis. Journal of Feline Medicine and Surgery.
  12. Gladwin, N.E., Penninck, D.G., Webster, C.R.L. 2014. Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs. American Journal of Veterinary Research.
  13. Won Park, S., Schonhoff, C.M., Anwer, M.S., Webster, C.R.L. 2014. Rab11, but not Rab4, facilitates cyclic AMP- and tauroursodeoxycholate-induced MRP2 translocation to the plasma membrane. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  14. Kelley, D., Lester, C., Delaforcade, A., Webster, C.R.L. 2013. Thromboelastographic evaluation of dogs with congenital portosystemic shunts. Journal of Veterinary Internal Medicine.
  15. Schonhoff, C.M., Webster, C.R.L., Anwer, M.S. 2013. Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cε{lunate} in HUH-NTCP Cells. Hepatology.
  16. Penninck, D.G., Zeyen, U., Taeymans, O.N., Webster, C.R. 2013. Ultrasonographic measurement of the pancreas and pancreatic duct in clinically normal dogs. American Journal of Veterinary Research.
  17. Weissman, A., Penninck, D., Webster, C., Hecht, S., Keating, J., Craig, L.E. 2013. Ultrasonographic and clinicopathological features of feline gastrointestinal eosinophilic sclerosing fibroplasia in four cats. Journal of Feline Medicine and Surgery.
  18. Park, S.W., Schonhoff, C.M., Webster, C.R.L., Sawkat Anwer, M. 2012. Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane. American Journal of Physiology - Gastrointestinal and Liver Physiology.
  19. Webster, C.R.L. 2012. Hepatobiliary Cytoprotective Agents. Canine and Feline Gastroenterology.
  20. Respess, M., O'Toole, T.E., Taeymans, O., Rogers, C.L., Johnston, A., Webster, C.R.L. 2012. Portal Vein Thrombosis in 33 Dogs: 1998-2011. Journal of Veterinary Internal Medicine.

General Research Interests

  • Cholestatic liver disease in dogs and cats, bile acid hepatotoxicity, hepatocyte apoptosis/survival signaling.

Selected Research Projects

  • Role of cAMP signaling through cAMP-GEF in hepatocyte survival.
  • Role of bile acid apoptosis in cholestatic liver disease.
  • Novel stem cell intervention in cholestatic liver disease in dogs and cats.
  • Coagulation and liver disease.

Research and Clinical Interests

  • Signal transduction in hepatocyte apoptosis.
  • Molecular mechanisms of pathogenesis in cholestatic liver disease.
  • Hormonal control of hepatocyte survival.
  • Diagnosis and therapeutic intervention in canine and feline cholestatic liver disease.

Teaching

  • Gastrointestinal/hepatic pathology/pharmacology
  • Small animal medicine, gastrointestinal/hepatic medicine
  • Clinical rotations, small animal medicine
  • Pathobiology: Cholestasis

Research Interests by Area

Hepatic Diseases
  • Mechanism of hepatocellular apoptosis; pathophysiology of feline and canine hepatic disorder
  • Pathophysiology of feline and canine hepatic disorders
  • Cholestatic liver disorders in dogs and cats; Coagulation in liver disease in dogs and cats. Basic: Mechanisms of bile formation; bile acid signaling; hepatotoxicity
Regenerative Medicine
  • Clinical application of stem cells for liver disease.
Spontaneous Animal Disease Models
  • Chronic hepatitis in dogs including Labrador hepatopathy, chronic cholangiopathies in cats, gastrointestinal/hepatobiliary neoplasia, hepatic steatosis in cats, hepatic nodular hyperplasia, inflammatory bowel disease, pancreatitis, inflammatory bowel disease, hepatocutaneous syndrome, congenital vascular anomalies, fibropolycystic liver diseases

Major Specialized Equipment

  • Fully equipped cell biology laboratory.
  • Isolation and culture of primary hepatocytes.