Cummings School of Veterinary Medicine at Tufts University
Cynthia R. L. Webster

Associate Chair; Cholestatic Liver Disease, Small Animal Medicine

Dr.Cynthia Webster is an expert in canine and feline liver disease and a board-certified small animal medicine internist. At the Cummings School, she leads the veterinary Liver Study Group, an umbrella organization of the Comparative Gastroenterology Society. Her research interests include how the liver regulates its ability to survive after toxic insults, especially during times when bile flow is attenuated.

Dr.Webster grew up in a small town in western Massachusetts. She says she was drawn to comparative medicine so that she could one day not only care for dogs and cats, but also solve problems in human medicine. After attending Cornell University's veterinary school and doing post-graduate work in liver disease at Tufts University School of Medicine,Dr.Webster now has a joint appointment that allows her to do just that: she teaches gastrointestinal and liver pharmacology, pathology and medicine toDVMstudents at the Cummings School and lectures graduate students at Tufts Sackler School in Boston.

It is hard to not be a great doctor in this environment,Dr.Webster says of the Cummings School.At the Foster Hospital for Small Animals, you have so many brilliant minds to work with and experts in every discipline. I love being able to do biomedical research one day, work with owners and their pets the next, and through it all still have the ability to train the next generation of veterinarians.

Dr.Webster lives in Grafton with her husband and son. She is active in the Grafton public schools and organizes Tufts' outreach efforts—ranging from science lectures to career days. She admits to being a cat lady and has two cats at home she adores.

Education

  • DVM - Cornell University - 1985
  • BS - Simmons College - 1978

House Officer Training

  • ACVIM Small Animal Medicine - TCSVM

Board Certification

  • Diplomate, American College of Veterinary Internal Medicine (Small Animal)

Ultrasonographic evaluation of the thickness of the wall layers in the intestinal tract of dogs

Author(s):Gladwin, N.E. | Penninck, D.G. | Webster, C.R.L.
Publication year: 2014
Journal / Book title: American Journal of Veterinary Research

Thromboelastographic evaluation of dogs with congenital portosystemic shunts

Author(s):Kelley, D. | Lester, C. | Delaforcade, A. | Webster, C.R.L.
Publication year: 2013
Journal / Book title: Journal of Veterinary Internal Medicine

Taurolithocholate-induced MRP2 retrieval involves MARCKS phosphorylation by protein kinase Cε{lunate} in HUH-NTCP Cells

Author(s):Schonhoff, C.M. | Webster, C.R.L. | Anwer, M.S.
Publication year: 2013
Journal / Book title: Hepatology

Ultrasonographic measurement of the pancreas and pancreatic duct in clinically normal dogs

Author(s):Penninck, D.G. | Zeyen, U. | Taeymans, O.N. | Webster, C.R.
Publication year: 2013
Journal / Book title: American Journal of Veterinary Research

Ultrasonographic and clinicopathological features of feline gastrointestinal eosinophilic sclerosing fibroplasia in four cats

Author(s):Weissman, A. | Penninck, D. | Webster, C. | Hecht, S. | Keating, J. | Craig, L.E.
Publication year: 2013
Journal / Book title: Journal of Feline Medicine and Surgery

Protein kinase Cδ differentially regulates cAMP-dependent translocation of NTCP and MRP2 to the plasma membrane

Author(s):Park, S.W. | Schonhoff, C.M. | Webster, C.R.L. | Sawkat Anwer, M.
Publication year: 2012
Journal / Book title: American Journal of Physiology - Gastrointestinal and Liver Physiology

Hepatobiliary Cytoprotective Agents

Author(s):Webster, C.R.L.
Publication year: 2012
Journal / Book title: Canine and Feline Gastroenterology

Portal Vein Thrombosis in 33 Dogs: 1998-2011

Author(s):Respess, M. | O'Toole, T.E. | Taeymans, O. | Rogers, C.L. | Johnston, A. | Webster, C.R.L.
Publication year: 2012
Journal / Book title: Journal of Veterinary Internal Medicine

Coagulation in hepatobiliary disease

Author(s):Kavanagh, C. | Shaw, S. | Webster, C.R.
Publication year: 2011
Journal / Book title: Journal of Veterinary Emergency and Critical Care

cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-jun NH 2-terminal kinase

Author(s):Johnston, A. | Ponzetti, K. | Anwer, M.S. | Webster, C.R.L.
Publication year: 2011
Journal / Book title: American Journal of Physiology - Gastrointestinal and Liver Physiology

Ultrasonographic characterization of feline ileocecocolic abnormalities

Author(s):Taeymans, O. | Holt, N. | Penninck, D.G. | Webster, C.R.
Publication year: 2011
Journal / Book title: Veterinary Radiology and Ultrasound

Portal Hypertension: Pathophysiology, Diagnosis, and Treatment

Author(s):Buob, S. | Johnston, A.N. | Webster, C.R.L.
Publication year: 2011
Journal / Book title: Journal of Veterinary Internal Medicine

Sonographic assessment of gallbladder volume in normal cats

Author(s):Penninck, D.G. | Brisson, J.O. | Webster, C.R.L.
Publication year: 2010
Journal / Book title: Veterinary Radiology and Ultrasound

Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells

Author(s):Hohenester, S. | Gates, A. | Wimmer, R. | Beuers, U. | Anwer, M.S. | Rust, C. | Webster, C.R.L.
Publication year: 2010
Journal / Book title: Journal of Hepatology

Ultrasonographic assessment of long-term enterectomy sites in dogs

Author(s):Mareschal, A. | Penninck, D. | Webster, C.R.L.
Publication year: 2010
Journal / Book title: Veterinary Radiology and Ultrasound

The sonographic appearance of intestinal mucosal fibrosis in cats

Author(s):Penninck, D.G. | Webster, C.R.L. | Keating, J.H.
Publication year: 2010
Journal / Book title: Veterinary Radiology and Ultrasound

Cyclic AMP stimulates Mrp2 translocation by activating p38α MAPK in hepatic cells

Author(s):Schonhoff, C.M. | Webster, C.R.L. | Anwer, M.S.
Publication year: 2010
Journal / Book title: American Journal of Physiology - Gastrointestinal and Liver Physiology

PKCε-dependent and -independent effects of taurolithocholate on PI3K/PKB pathway and taurocholate uptake in HuH-NTCP cell line

Author(s):Schonhoff, C.M. | Yamazaki, A. | Hohenester, S. | Webster, C.R.L. | Bouscarel, B. | Anwer, M.S.
Publication year: 2009
Journal / Book title: American Journal of Physiology - Gastrointestinal and Liver Physiology

Hepatocyte Apoptosis

Author(s):Webster, C.R.L.
Publication year: 2009
Journal / Book title: The Liver: Biology and Pathobiology: Fifth Edition

Therapeutic Use of Cytoprotective Agents in Canine and Feline Hepatobiliary Disease

Author(s):Webster, C.R.L. | Cooper, J.
Publication year: 2009
Journal / Book title: Veterinary Clinics of North America - Small Animal Practice

General Research Interests

  • Cholestatic liver disease in dogs and cats, bile acid hepatotoxicity, hepatocyte apoptosis/survival signaling.

Selected Research Projects

  • Role of cAMP signaling through cAMP-GEF in hepatocyte survival.
  • Role of bile acid apoptosis in cholestatic liver disease.
  • Novel stem cell intervention in cholestatic liver disease in dogs and cats.
  • Coagulation and liver disease.

Teaching

  • Gastrointestinal/hepatic pathology/pharmacology
  • Small animal medicine, gastrointestinal/hepatic medicine
  • Clinical rotations, small animal medicine
  • Pathobiology: Cholestasis

Research Interests by Area

Hepatic Diseases
  • Mechanism of hepatocellular apoptosis; pathophysiology of feline and canine hepatic disorder
  • Pathophysiology of feline and canine hepatic disorders
  • Cholestatic liver disorders in dogs and cats; Coagulation in liver disease in dogs and cats. Basic: Mechanisms of bile formation; bile acid signaling; hepatotoxicity
Regenerative Medicine
  • Clinical application of stem cells for liver disease.
Spontaneous Animal Disease Models
  • Chronic hepatitis in dogs including Labrador hepatopathy, chronic cholangiopathies in cats, gastrointestinal/hepatobiliary neoplasia, hepatic steatosis in cats, hepatic nodular hyperplasia, inflammatory bowel disease, pancreatitis, inflammatory bowel disease, hepatocutaneous syndrome, congenital vascular anomalies, fibropolycystic liver diseases

Major Specialized Equipment

  • Fully equipped cell biology laboratory.
  • Isolation and culture of primary hepatocytes.