Emergency Medicine & Critical Care, Coagulation
Dr. Armelle de Laforcade serves on the Emergency and Critical Care team at one of the nation's busiest teaching animal ERs, in the Foster Hospital for Small Animals. As a criticalist certified by the American College of Veterinary Emergency and Critical Care, she cares for the very sick and injured animals that require 24-hour care and advanced monitoring. In addition to her clinical duties, she teaches courses on subjects ranging from sepsis to coagulation, as well as the business of veterinary medicine.
A first-generation American, Dr. de Laforcade grew up on the north shore of Boston, with the exception of a few years spent in the south of France. She began riding horses while living in France and after returning to the United States cared for a horse of her own. Her love of horses led her to study veterinary medicine at Tufts. Although determined to practice equine medicine, she spent time in the small animal emergency room as a second-year student and felt right at home. After earning her DVM from the Cummings School in 1997, she completed a residency in the ECC section, then stayed on as a faculty member, drawn by the opportunity to combine cutting-edge medicine with teaching students, interns and residents.
To this day, I am very grateful to those teachers along the way who gave me opportunities that helped me find my way, she says.
I hope to have the same effect on students discovering veterinary medicine at Tufts.
Among her favorite patients is a dog named
Norton who ate a tennis ball that was surgically removed by a referring veterinarian. Following the surgery, however, Norton's health began to decline and he was rushed to the Foster Hospital for intensive care. While being treated with intravenous fluids, Dr. de Laforcade and her care team determined that Norton had an underlying endocrine problem known as
hypoadrenocorticism. Once treated, Norton recovered just fine and, with lifelong treatment, he lived a long life.
She lives with her husband, Lee, and her twin boys, Nicholas and Tristan, as well as a Golden Retriever named Mayday and 2 Peking ducks they adopted from Tufts. She grew up sailing, and she and Lee enjoy racing their J24 with her family in regattas from Annapolis to Maine, as well as traveling to Europe to visit her family.
- DVM - Tufts University - 1997
- BS - Cornell University - 1993
- Majoy SB, deLaforcade AM, Barnard MR, et al. Platelet activation in a hospitalized population of critically ill dogs as measured by whole blood flow cytometry and thromboelastography. Am J Vet Res 2015; 76(4): 328-337.
- Kelley D, Lester C, Shaw S, de Laforcade A, Webster C. Thromboelastographic evaluation of dogs with acute liver disease. J Vet Intern Med 2015; 29:1053-1062.
- Fletcher D, Rozanski EA, Brainard B, deLaforcade AM, Brooks M. Assessment of the relationships among coagulopathy, hyperfibrinolysis, plasma lactate, and protein C in dog with spontaneous hemoperitoneum. J Vet Emerg Crit Care 2015; 26(1): 41-51.
- Morris B, deLaforcade AM, Lee J, et al. Effects of in vitro hemodilution with crystalloids, colloids, and plasma on canine whole blood coagulation as determined by kaolin-activated thromboelastography. J Vet Emerg Crit Care 2016; 26(1):28-63.
- Yang VK, Cunningham SM, Rush JE, de Laforcade A. The use of rivaroxaban for the treatment of thrombotic complications in four dogs. J Vet Emerg Crit Care 2016; 26(5):729-36.
- Lynch AM, deLaforcade AM, Meola D, et al. Assessment of hemostatic changes in a model of acute hemorrhage in dogs. J Vet Emerg Crit Care 2016; 26(3):333-343.
- Da'dara AA, deLaforcade AM, Skelly PJ. The impact of schistosomes and schistosomiasis on murine blood coagulation and fibrinolysis as determined by thromboelastography (TEG). J Thromb Thrombolysis. 2016; 41(4): 671-677.
- Crane C, Rozanski EA, Abelson AL, deLaforcade A. Severe brachycephalic obstructive airway syndrome is associated with hypercoagulability in dogs. J Vet Diag Invest 2017; 29(4):570-573.
- Lynch AM, Respess M, Boll AE, Bozych M, McMichael M, Fletcher DJ, deLaforcade AM, Rozanski EA. Hospital-acquired anemia in critically ill dgos and cats: a multi-institutional study. J Vet Intern Med 2016; 30(1):141-146.
- Fry W, Lester C, Etedali NM, Shaw S, deLaforcade A, Webster CR. Thromboelastography in dogs with chronic hepatopathies. J Vet Intern Med 2017; 31(2):419-426.
- Buckley F, Mahony O, deLaforcade A, Webster C. Adrenal function in cats with cholestatic hepatobiliary disease. In press, J Vet DIag Inv
- Frydman GH, Metcalf Pate KA, Marini RP, deLaforcade AM, et al. Adult-onset, chronic, cyclic thrombocytopenia in a rhesus macaque (Macaca mulatta) after dengue virus vaccination and viral challenge. Vet Clin Pathol 2017; 46(2): 238-247.
- Dorsey TI, Monaghan KN, Respess M, Labato MA, Babyak JM, Sharp CR, Rozanski EA, deLaforcade AM. Influence of urinary bladder flushing on duration of catheterization, hospitalization and recurrence in cats with urethral obstruction. J Am Vet Med Assoc 2017; in press.
- Goggs R, Borrelli A, Brainard B, Chan D, deLaforcade A, et al. Multicenter in vitro TEG-ROTEM standardization. J Vet Emerg Crit Care 2018; doi: 10.1111/vec.12710 (Epub ahead of print).
- Dorsey TI, Rozanski EA, Sharp CR, deLaforcade AM. Evaluation of thromboelastography in bitches with pyometra. J Vet Diag Invest 2017;30(1): 165-168.
- Vaught ME, Rozanski EA, deLaforcade AM. Effect of transoral tracheal wash on respiratory mechanics in dogs with respiratory disease. Can J Vet Res 2018; 82(1):75-79.
- Elzoheiry M, Da’Dara AA, deLaforcade AM, El Beshbishi SN, Skelly PJ. The essential ectoenzyme SmNPP5 from the human intravascular parasite shcistosoma mansoni is an ADPase and a potent inhibitor of platelet aggregation. Thromb Haemost 2018; doi: 10.1055/s-0038-1641715 (Epub ahead of print).
- Marschner CB, Kristensen AT, Rozanski EA, McEvoy FJ, Kuhnel L, Taeymans O, de Laforcade A, Sato AF, WIinberg B. Diagnosis of canine pulmonary thromboembolism by computed tomography and mathematical modelling using haemostatic and inflammatory variables. Vet J 2017; 229:6-12.
General Research Interests
Coagulation changes in critical illness and in severe trauma; development of protocols for anticoagulant use in the veterinary setting; monitoring anticoagulation therapy; diagnosis and management of severe sepsis and septic shock; alterations in microvascular perfusion in trauma and in critical illness.
Selected Research Projects
- Evaluation of thromboelastography as a sensitive marker of coagulation abnormalities in sepsis.
- Evaluation of thromboelastography in dogs following severe trauma.
- Evaluating abdominal fluid cytology, biochemistry, and culture in dogs post-operatively following source control for abdominal sepsis.
Research Interests by Area
Spontaneous Animal Disease Models
- Coagulopathies associated with sepsis, liver disease, renal disease, rodenticide, DIC, and trauma. Immune-mediated hemolytic anemia and thrombocytopenia
Research Interests by Organ System and Disease
Emergency and Critical Care
- Evaluation of thrombo-elastography as a sensitive marker of coagulation abnormalities in sepsis and in dogs following severe trauma. Coagulopathies, clinical critical care research, hypercoagulability and thormbosis, anticoagulation monitoring
Major Specialized Equipment
- ACL Elite hemostasis analyzer
- Multiplate aggregometer
- Microscan video microscope