Cummings School of Veterinary Medicine at Tufts University
Andrew M. Hoffman

Internal Medicine, Respiratory Physiology, Regenerative Medicine

Professor, Large Animal Internal Medicine

Dr. Andrew Hoffman is a Professor of Large Animal Internal Medicine with three decades of experience teaching, clinical service, and research. Dr. Hoffman’s major areas of expertise include pulmonary physiology, tissue engineering, and stem cell-based therapies. Dr. Hoffman developed the first outpatient pulmonary function testing unit for veterinary patients in North America which currently operates in the Hospital for Large Animals. He directs the Regenerative Medicine Laboratory (RML) that serves as a research and laboratory core for Clinical Science faculty engaged in research related to stem cells and regenerative medicine. Dr. Hoffman’s laboratory has continuously received funding from the National Institute of Health (NIH) since 1999, in addition to numerous industry and foundation awards.

At present, the main focus of Dr. Hoffman’s clinical research is mesenchymal stem cell (MSC) safety, potency, and biological activity, in veterinary and by extension human patients with a variety of persistent diseases. Mechanisms by which MSCs convey immunoregulatory and anti-inflammatory signals to recipient cells that are under investigation include, the release of soluble mediators and extracellular vesicles (nanoparticles). In addition to these more basic science questions, the RML directed by Dr. Hoffman facilitates clinical trials in veterinary patients, including the training and supervision of clinical trial technicians and coordinators, laboratory support including measurement of biomarkers and cells (flow cytometry), study design, quality control, and biostatistics. Examples of veterinary clinical trials facilitated by the RML include the effects of MSCs on autoimmune disease (perianal fistulas, granulomatous meningoencephalomyelitis, immune complex glomerulonephritis, and hepatitis), sepsis, osteoarthritis, and inter-vertebral disc disease progression in dogs. Additionally Dr. Hoffman is currently a Principal Investigator on a translational project funded by NIH entitled ‘Autologous mesenchymal stem cell therapy for emphysema’ (R01 HL112987-01A1) which aims to understand how stem cells enhanced by biological scaffolds can activate the repair of the emphysema lung.

The RML also offers Post-Doctoral training opportunities for veterinarians who have completed their Veterinary Residency programs, which are supported by NIH and Foundation funding. Finally, the RML is responsible for maintaining the animal stem cell bank, comprised of a variety of stem cell lines from veterinary patients with naturally occurring diseases for studies of disease mechanisms, and cell lines from normal animals (dogs, cats, horses) intended for use in clinical trials.. Dr. Andrew Hoffman received an Exceptional Service Award at Tufts University Cummings School of Veterinary Medicine in 2013 for activities as Director of the RML. He resides with his family in Sutton, MA.

Education

  • D.V.Sc. - University of Guelph, Ontario Veterinary College - 1990
  • D.V.M. - Cornell University - 1985

Board Certification

  • ACVIM (Large Animal Medicine)
  1. Dino Sokocevic, Nicholas Bonenfant,, Zachary D. Borg, Darcy Wagner, Melissa Lathrop, Ying Wai Lam, Ph.D., Bin Deng, Michael DeSarno, Taka Ashikaga, Roberto Loi, Andrew M. Hoffman, Daniel J. Weiss (2013). The Effect of Age and Emphysematous and Fibrotic Injury on the Re-Cellularization of De-Cellularized Lungs, Biomaterials. 34(13):3256-69.
  2. Philip Eisenhauer, Benjamin Earle, Roberto Loi, Viranuj Sueblinvong, Meagan Goodwin, Gilman B. Allen, Lennart Lundblad, Melissa R. Mazan, Andrew M. Hoffman, Daniel J. Weiss (2013). Endogenous Distal Airway Progenitor Cells, Lung Mechanics, and Disproportionate Lobar Growth following Long-Term Post-Pneumonectomy in Mice. Stem Cells 31(7):1330-9.
  3. Michael A. Matthay, Piero Anversa, Jahar Bhattacharya, Bruce K. Burnett, Harold A. Chapman, Joshua M. Hare, Derek J. Hei, Andrew M. Hoffman, Stella Kourembanas, David H. McKenna, Luis A. Ortiz, Harald Ott, William Tente, Bernard Thébaud, Bruce C. Trapnell, Daniel J. Weiss, Jason X.-J. Yuan, Carol J. Blaisdell (2013). Cell Therapy for Lung Disease. Report from an NIH-NHLBI Workshop November 13-14 2012. Am J Respir Crit Care Med. 1;188(3):370-5.
  4. Darcy E. Wagner, Ryan Bonvillain, Todd Jensen, Eric D. Girard, Bruce A. Bunnell, Christine M. Finck, Andrew M. Hoffman, Daniel J. Weiss (2013). Invited Review: Can Stem Cells be Used to Generate New Lungs? Ex Vivo Lung Bioengineering with Decellularized Whole Lung Scaffolds. Respirology. 18(6):895-911
  5. Paxson J, Gruntman AM, Davis AM, Parkin CM, Ingenito EP, and Hoffman AM (2013). Age Dependence of Lung Mesenchymal Stromal Cell Dynamics Following Pneumonectomy, Stem Cells Dev. 15;22(24):3214-25
  6. Thane K, Ingenito EP, and Hoffman AM. Invited Review (2013): Lung regeneration and translational implications of the post-pneumonectomy model. Transl Res. S1931-5244(13)00427-1.
  7. Hoffman AM, Ingenito EP. (2012) Invited Review. Alveolar epithelial stem and progenitor cells: emerging evidence for their role in lung regeneration. Curr Med Chem. 2012;19(35):6003-8.
  8. Ingenito EP, Tsai L, Murthy S, Mazan MR, and Hoffman AM (2012). Autologous lung mesenchymal stem cell transplantation in an emphysema model. Cell Transplant, Feb 3, ePub ahead of print;PMID 21294955.
  9. Pacheco A, Bedenice D, Mazan M, and Hoffman AM. (2011) Respiratory mechanics and bronchoalveolar lavage in healthy adult alpacas. Am J Vet Res, in press, Jan 2012. doi: 10.2460/ajvr.73.1.146
  10. Paxson J, Gruntman A, Parkin C, Mazan M, Davis A, Ingenito E, and Hoffman AM (2011). Age dependent decline in lung regeneration with loss of clonogenicity and myofibroblast differentiation of lung fibroblasts.PlosOne, Published August 30, 2011 10.1371/journal.pone.0023232.
  11. Pritchard S, Hoffman AM, Johnson KL, Bianchi DW (2011). Pregnancy-associated progenitor cells: An under-recognized potential source of stem cells in maternal lung. Placenta [Epub ahead of print], PMID: 21546085. Published On-Line April 7, 2011.
  12. Hoffman AM, Paxson J, Mazan M, Davis A, Tyagi S, Murthy S, and Ingenito EP (2011). Lung mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase injured lung.  Stem Cells Develop, DOI: 10.1089/scd.2011.0105; PMID 21585237. Published Sept 28, 2011.
  13. Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola K, Nolen-Walston R, Kim CF, Tsai L, Pierce RA, Mecham R, and Ingenito EP (2010). Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice. Am J Physiol: Lung Cell Mol Physiol 298:L158-68; PMID 19915155.
  14. Ingenito EP, Sen E, Tsai L, Murthy S, Hoffman AM (2010). Design and testing of biological scaffolds for delivery reparative cells to target sites in the lung. J Tiss Eng Reg Med 4:259-272; PMID: 20020503.

View Dr. Hoffman's publications on PubMed.

Research Interests by Area

Regenerative Medicine
  • Stem cell biology. Tissue regeneration. Clinical applications of stem cell therapies
Spontaneous Animal Disease Models
  • Regenerative medicine applications for spontaneous animal diseases

Research Interests by Organ System and Disease

Respiratory Diseases
  • Comparative respiratory physiology,lung mechanics, device development, asthma, emphysema. Use of stem cells to regenerate lung tissue. Tissue engineering approaches to lung disease