An expert in equine lung function, Dr. Andrew Hoffman is a Professor, researcher, and clinician at the Cummings School of Veterinary Medicine's Hospital for Large Animals. Working on a farm as a young man drew Dr. Hoffman to pursue veterinary medicine, and he holds both a Doctor of Veterinary Medicine degree as well as a Doctorate of Veterinary Science in microbiology and pathology.
Prior to joining the faculty at the Cummings School, Dr. Hoffman undertook post-doctoral fellowships at Israel's Koret School of Veterinary Medicine and the University of Guelph in Ontario, Canada. He was drawn to join the Cummings School faculty by his desire to pursue both clinical medicine and research, the school's proximity to the biomedical research stronghold of Boston, and a longing to return to New England, where he had previously practiced as an equine and dairy veterinarian.
Currently, Dr. Andrew Hoffman teaches Systems Pathophysiology and Biomedical Engineering. His proudest moments, he says, are when residents or post-doctoral fellows he has overseen attain their first faculty position. His laboratory has been fortunate to see seven trainees awarded competitive faculty positions at veterinary schools, including two at Tufts (Dr. Daniela Bedenice and Dr. Melissa Mazan).
His current research focuses on new approaches to cell-based therapy for chronic lung diseases such as emphysema and pulmonary fibrosis and has led to an important therapy for emphysema that has completed Phase I and II clinical trials in humans. His latest research centers around which cells in the lung have potential to repair damaged tissue, including stem cells derived from lung tissue.
In his spare time, Andrew Hoffman enjoys activities such as boating, scuba diving, mountain climbing, and renovating old houses.
Pacheco A, Bedenice D, Mazan M, and Hoffman AM. (2011) Respiratory mechanics and bronchoalveolar lavage in healthy adult alpacas. Am J Vet Res, in press, Jan 2012. doi: 10.2460/ajvr.73.1.146
Paxson J, Gruntman A, Parkin C, Mazan M, Davis A, Ingenito E, andHoffman AM (2011). Age dependent decline in lung regeneration with loss of clonogenicity and myofibroblast differentiation of lung fibroblasts.PlosOne, Published August 30, 2011 10.1371/journal.pone.0023232.
Pritchard S, Hoffman AM, Johnson KL, Bianchi DW (2011). Pregnancy-associated progenitor cells: An under-recognized potential source of stem cells in maternal lung. Placenta [Epub ahead of print], PMID: 21546085. Published On-Line April 7, 2011.
Hoffman AM, Paxson J, Mazan M, Davis A, Tyagi S, Murthy S, and Ingenito EP (2011). Lung mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase injured lung.Â Stem Cells Develop, DOI: 10.1089/scd.2011.0105; PMID 21585237. Published Sept 28, 2011.
Ingenito EP, Tsai L, Murthy S, Mazan MR, and Hoffman AM (2011). Autologous lung mesenchymal stem cell transplantation in an emphysema model. Cell Transplant, Feb 3, ePub ahead of print;PMID 21294955.
Hoffman AM, Shifren A, Mazan MR, Gruntman AM, Lascola K, Nolen-Walston R, Kim CF, Tsai L, Pierce RA, Mecham R, and Ingenito EP (2010). Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice. Am J Physiol: Lung Cell Mol Physiol 298:L158-68; PMID 19915155.
Ingenito EP, Sen E, Tsai L, Murthy S, Hoffman AM (2010). Design and testing of biological scaffolds for delivery reparative cells to target sites in the lung. J Tiss Eng Reg Med 4:259-272; PMID: 20020503.