Cummings School of Veterinary Medicine at Tufts University
Andrew M. Hoffman

Internal Medicine, Respiratory Physiology, Regenerative Medicine

Professor, Large Animal Internal Medicine

Dr. Andrew Hoffman is a Professor of Large Animal Internal Medicine with three decades of experience teaching, clinical service, and research. Dr. Hoffman’s major areas of expertise include pulmonary physiology, tissue engineering, and stem cell-based therapies. Dr. Hoffman developed the first outpatient pulmonary function testing unit for veterinary patients in North America which currently operates in the Hospital for Large Animals. He directs the Regenerative Medicine Laboratory (RML) that serves as a research and laboratory core for Clinical Science faculty engaged in research related to stem cells and regenerative medicine. Dr. Hoffman’s laboratory has continuously received funding from the National Institute of Health (NIH) since 1999, in addition to numerous industry and foundation awards.

At present, the main focus of Dr. Hoffman’s clinical research is mesenchymal stem cell (MSC) safety, potency, and biological activity, in veterinary and by extension human patients with a variety of persistent diseases. Mechanisms by which MSCs convey immunoregulatory and anti-inflammatory signals to recipient cells that are under investigation include, the release of soluble mediators and extracellular vesicles (nanoparticles). In addition to these more basic science questions, the RML directed by Dr. Hoffman facilitates clinical trials in veterinary patients, including the training and supervision of clinical trial technicians and coordinators, laboratory support including measurement of biomarkers and cells (flow cytometry), study design, quality control, and biostatistics. Examples of veterinary clinical trials facilitated by the RML include the effects of MSCs on autoimmune disease (perianal fistulas, granulomatous meningoencephalomyelitis, immune complex glomerulonephritis, and hepatitis), sepsis, osteoarthritis, and inter-vertebral disc disease progression in dogs. Additionally Dr. Hoffman is currently a Principal Investigator on a translational project funded by NIH entitled ‘Autologous mesenchymal stem cell therapy for emphysema’ (R01 HL112987-01A1) which aims to understand how stem cells enhanced by biological scaffolds can activate the repair of the emphysema lung.

The RML also offers Post-Doctoral training opportunities for veterinarians who have completed their Veterinary Residency programs, which are supported by NIH and Foundation funding. Finally, the RML is responsible for maintaining the animal stem cell bank, comprised of a variety of stem cell lines from veterinary patients with naturally occurring diseases for studies of disease mechanisms, and cell lines from normal animals (dogs, cats, horses) intended for use in clinical trials.. Dr. Andrew Hoffman received an Exceptional Service Award at Tufts University Cummings School of Veterinary Medicine in 2013 for activities as Director of the RML. He resides with his family in Sutton, MA.

Education

  • D.V.Sc. - University of Guelph, Ontario Veterinary College - 1990
  • D.V.M. - Cornell University - 1985

Board Certification

  • ACVIM (Large Animal Medicine)

Owner-reported coughing and nasal discharge are associated with clinical findings, arterial oxygen tension, mucus score and bronchoprovocation in horses with recurrent airway obstruction in a field setting

Author(s):Rettmer, H. | Hoffman, A.M. | Lanz, S. | Oertly, M. | Gerber, V.
Publication year: 2014
Journal / Book title: Equine Veterinary Journal

Age effects on blood gas, spirometry, airway reactivity, and bronchoalveolar lavage fluid cytology in clinically healthy horses

Author(s):Pacheco, A.P. | Paradis, M.R. | Hoffman, A.M. | Hermida, P. | Sanchez, A. | Nadeau, J.A. | Tufts, M. | Mazan, M.R.
Publication year: 2014
Journal / Book title: Journal of Veterinary Internal Medicine

Use of a novel one-nostril mask-spacer device to evaluate airway hyperresponsiveness (AHR) in horses after chronic administration of albuterol

Author(s):Mazan, M.R. | Lascola, K. | Bruns, S.J. | Hoffman, A.M.
Publication year: 2014
Journal / Book title: Canadian Journal of Veterinary Research

Lung regeneration and translational implications of the postpneumonectomy model

Author(s):Thane, K. | Ingenito, E.P. | Hoffman, A.M.
Publication year: 2014
Journal / Book title: Translational Research

Age dependence of lung mesenchymal stromal cell dynamics following pneumonectomy

Author(s):Paxson, J.A. | Gruntman, A.M. | Davis, A.M. | Parkin, C.M. | Ingenito, E.P. | Hoffman, A.M.
Publication year: 2013
Journal / Book title: Stem Cells and Development

Can stem cells be used to generate new lungs? Ex vivo lung bioengineering with decellularized whole lung scaffolds

Author(s):Wagner, D.E. | Bonvillain, R.W. | Jensen, T. | Girard, E.D. | Bunnell, B.A. | Finck, C.M. | Hoffman, A.M. | Weiss, D.J.
Publication year: 2013
Journal / Book title: Respirology

Cell therapy for lung diseases report from an NIH-NHLBI workshop, november 13-14, 2012

Author(s):Matthay, M.A. | Anversa, P. | Bhattacharya, J. | Burnett, B.K. | Chapman, H.A. | Hare, J.M. | Hei, D.J. | Hoffman, A.M. | Kourembanas, S. | McKenna, D.H. | Ortiz, L.A. | Ott, H.C. | Tente, W. | Thebaud, B. | Trapnell, B.C. | Weiss, D.J. | Yuan, J.X.-J. | Blaisdell, C.J.
Publication year: 2013
Journal / Book title: American Journal of Respiratory and Critical Care Medicine

Endogenous distal airway progenitor cells, lung mechanics, and disproportionate lobar growth following long-term postpneumonectomy in mice

Author(s):Eisenhauer, P. | Earle, B. | Loi, R. | Sueblinvong, V. | Goodwin, M. | Allen, G.B. | Lundblad, L. | Mazan, M.R. | Hoffman, A.M. | Weiss, D.J.
Publication year: 2013
Journal / Book title: Stem Cells

The effect of age and emphysematous and fibrotic injury on the re-cellularization of de-cellularized lungs

Author(s):Sokocevic, D. | Bonenfant, N.R. | Wagner, D.E. | Borg, Z.D. | Lathrop, M.J. | Lam, Y.W. | Deng, B. | DeSarno, M.J. | Ashikaga, T. | Loi, R. | Hoffman, A.M. | Weiss, D.J.
Publication year: 2013
Journal / Book title: Biomaterials

Alveolar epithelial stem and progenitor cells: Emerging evidence for their role in lung regeneration

Author(s):Hoffman, A.M. | Ingenito, E.P.
Publication year: 2012
Journal / Book title: Current Medicinal Chemistry

Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema

Author(s):Ingenito, E.P. | Tsai, L. | Murthy, S. | Tyagi, S. | Mazan, M. | Hoffman, A.
Publication year: 2012
Journal / Book title: Cell Transplantation

Respiratory mechanics and results of cytologic examination of bronchoalveolar lavage fluid in healthy adult alpacas

Author(s):Pacheco, A.P. | Bedenice, D. | Mazan, M.R. | Hoffman, A.M.
Publication year: 2012
Journal / Book title: American Journal of Veterinary Research

Lung-derived mesenchymal stromal cell post-transplantation survival, persistence, paracrine expression, and repair of elastase-injured lung

Author(s):Hoffman, A.M. | Paxson, J.A. | Mazan, M.R. | Davis, A.M. | Tyagi, S. | Murthy, S. | Ingenito, E.P.
Publication year: 2011
Journal / Book title: Stem Cells and Development

Pregnancy-associated progenitor cells: An under-recognized potential source of stem cells in maternal lung

Author(s):Pritchard, S. | Hoffman, A.M. | Johnson, K.L. | Bianchi, D.W.
Publication year: 2011
Journal / Book title: Placenta

Age-dependent decline in mouse lung regeneration with loss of lung fibroblast clonogenicity and increased myofibroblastic differentiation

Author(s):Paxson, J.A. | Gruntman, A. | Parkin, C.D. | Mazan, M.R. | Davis, A. | Ingenito, E.P. | Hoffman, A.M.
Publication year: 2011
Journal / Book title: PLoS ONE

Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung

Author(s):Ingenito, E.P. | Sen, E. | Tsai, L.W. | Murthy, S. | Hoffman, A.
Publication year: 2010
Journal / Book title: Journal of Tissue Engineering and Regenerative Medicine

Matrix modulation of compensatory lung regrowth and progenitor cell proliferation in mice

Author(s):Hoffman, A.M. | Shifren, A. | Mazan, M.R. | Gruntman, A.M. | Lascola, K.M. | Nolen-Walston, R.D. | Kim, C.F. | Tsai, L. | Pierce, R.A. | Mecham, R.P. | Ingenito, E.P.
Publication year: 2010
Journal / Book title: American Journal of Physiology - Lung Cellular and Molecular Physiology

The effect of body position, sedation, and thoracic bandaging on functional residual capacity in healthy deep-chested dogs

Author(s):Rozanski, E.A. | Bedenice, D. | Lofgren, J. | Abrams, J. | Bach, J. | Hoffman, A.M.
Publication year: 2010
Journal / Book title: Canadian Journal of Veterinary Research

Global gene expression patterns in the post-pneumonectomy lung of adult mice

Author(s):Paxson, J.A. | Parkin, C.D. | Iyer, L.K. | Mazan, M.R. | Ingenito, E.P. | Hoffman, A.M.
Publication year: 2009
Journal / Book title: Respiratory Research

Questionnaire assessment of airway disease symptoms in equine barn personnel

Author(s):Mazan, M.R. | Svatek, J. | Maranda, L. | Christiani, D. | Ghio, A. | Nadeau, J. | Hoffman, A.M.
Publication year: 2009
Journal / Book title: Occupational Medicine

Research Interests by Area

Regenerative Medicine
  • Stem cell biology. Tissue regeneration. Clinical applications of stem cell therapies
Spontaneous Animal Disease Models
  • Regenerative medicine applications for spontaneous animal diseases

Research Interests by Organ System and Disease

Respiratory Diseases
  • Comparative respiratory physiology,lung mechanics, device development, asthma, emphysema. Use of stem cells to regenerate lung tissue. Tissue engineering approaches to lung disease