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Amanda Jezek Martinot - DVM, MPH, PhD, DACVP

Amanda Martinot is an Assistant Professor in the Department of Infectious Diseases and Global Health.  She is a veterinarian-scientist and board-certified veterinary pathologist (anatomic) that specializes in animal models of infectious diseases of global health importance such as Tuberculosis (TB), HIV, and Zika virus. Dr. Martinot received her veterinary degree from the University of Florida College of Veterinary Medicine in 2003. She went on to study the epidemiology of infectious diseases and global health at the University of North Carolina at Chapel Hill where she completed her MPH in 2006. She specialized in comparative pathology and infectious diseases by completing her pathology residency training at the Harvard Medical School, New England Primate Research Center and her PhD at the Harvard School of Public Health where she studied the microbiology and immunopathology of Mycobacterium tuberculosis infectionWith over 10 years’ experience in TB biology, her independent research focuses on pre-clinical animal models for TB vaccine development and the basic immunology and virulence determinants underlying the TB host-pathogen interaction.  As a veterinary pathologist, Dr. Martinot has expertise in the non-human primate models of infectious disease pathogenesis, including SIV, Zika virus, and Hepacivirus infections.

Education

  • PhD  - Harvard School of Public Health - 2014
  • MPH - University of North Carolina at Chapel Hill - 2006
  • DVM - University of Florida - 2003
  • BS – University of Florida - 1999

Board Certification

  • Diplomate American College of Veterinary Pathologists
  1. Larocca, R.A., Mendes, E.A., Abbink, P., Peterson, R.L., Martinot, A.J., Iampietro, M.J., Kang, Z.H., Aid, M., Kirilova, M., Jacob-Dolan, C., Tostanoski, L., Borducchi, E.N., De La Barrera, R.A., Barouch, D.H. 2019. Adenovirus Vector-Based Vaccines Confer Maternal-Fetal Protection against Zika Virus Challenge in Pregnant IFN-αβR−/− Mice. Cell Host and Microbe.
  2. Blanc, L., Daudelin, I.B., Podell, B.K., Chen, P.-Y., Zimmerman, M., Martinot, A.J., Savic, R.M., Prideaux, B., Dartois, V. 2018. High-resolution mapping of fluoroquinolones in TB rabbit lesions reveals specific distribution in immune cell types. eLife.
  3. Chaudhuri, S., Li, L., Zimmerman, M., Chen, Y., Chen, Y.-X., Toosky, M.N., Gardner, M., Pan, M., Li, Y.-Y., Kawaji, Q., Zhu, J.-H., Su, H.-W., Martinot, A.J., Rubin, E.J., Dartois, V., Javid, B. 2018. Kasugamycin potentiates rifampicin and limits emergence of resistance in Mycobacterium tuberculosis by specifically decreasing mycobacterial mistranslation. eLife.
  4. Blass, E., Aid, M., Martinot, A.J., Larocca, R.A., Kang, Z.H., Badamchi-Zadeh, A., Penaloza-MacMaster, P., Reeves, R.K., Barouch, D.H. 2018. Adenovirus vector vaccination impacts NK cell Rrheostat function following lymphocytic choriomeningitis virus infection. Journal of Virology.
  5. Martinot, A.J., Abbink, P., Afacan, O., Prohl, A.K., Bronson, R., Hecht, J.L., Borducchi, E.N., Larocca, R.A., Peterson, R.L., Rinaldi, W., Ferguson, M., Didier, P.J., Weiss, D., Lewis, M.G., De La Barrera, R.A., Yang, E., Warfield, S.K., Barouch, D.H. 2018. Fetal Neuropathology in Zika Virus-Infected Pregnant Female Rhesus Monkeys. Cell.
  6. Martinot, A.J. 2018. Microbial Offense vs Host Defense: Who Controls the TB Granuloma?. Veterinary Pathology.
  7. Manickam, C., Martinot, A.J., Jones, R.A., Varner, V., Reeves, R.K. 2017. Hepatic immunopathology during occult hepacivirus re-infection. Virology.
  8. Bhattacharyya, M., Madden, P., Henning, N., Gregory, S., Aid, M., Martinot, A.J., Barouch, D.H., Penaloza-MacMaster, P. 2017. Regulation of CD4 T cells and their effects on immunopathological inflammation following viral infection. Immunology.
  9. Aid, M., Abbink, P., Larocca, R.A., Boyd, M., Nityanandam, R., Nanayakkara, O., Martinot, A.J., Moseley, E.T., Blass, E., Borducchi, E.N., Chandrashekar, A., Brinkman, A.L., Molloy, K., Jetton, D., Tartaglia, L.J., Liu, J., Best, K., Perelson, A.S., De La Barrera, R.A., Lewis, M.G., Barouch, D.H. 2017. Zika Virus Persistence in the Central Nervous System and Lymph Nodes of Rhesus Monkeys. Cell.
  10. Manickam, C., Wachtman, L., Martinot, A.J., Giavedoni, L.D., Reeves, R.K. 2017. Metabolic dysregulation in hepacivirus infection of common marmosets (Callithrix jacchus). PLoS ONE.
  11. Manickam, C., Rajakumar, P., Wachtman, L., Kramer, J.A., Martinot, A.J., Varner, V., Giavedoni, L.D., Reeves, R.K. 2016. Acute liver damage associated with innate immune activation in a small nonhuman primate model of hepacivirus infection. Journal of Virology.
  12. Martinot, A.J., Farrow, M., Bai, L., Layre, E., Cheng, T.-Y., Tsai, J.H., Iqbal, J., Annand, J.W., Sullivan, Z.A., Hussain, M.M., Sacchettini, J., Moody, D.B., Seeliger, J.C., Rubin, E.J. 2016. Mycobacterial Metabolic Syndrome: LprG and Rv1410 Regulate Triacylglyceride Levels, Growth Rate and Virulence in Mycobacterium tuberculosis. PLoS Pathogens.
  13. Madigan, C.A., Martinot, A.J., Wei, J.-R., Madduri, A., Cheng, T.-Y., Young, D.C., Layre, E., Murry, J.P., Rubin, E.J., Moody, D.B. 2015. Lipidomic Analysis Links Mycobactin Synthase K to Iron Uptake and Virulence in M. tuberculosis. PLoS Pathogens.
  14. Martinot, A.J., Miller, A., Kramer, J. 2015. Contributions of veterinary medicine to health research. Journal of the American Veterinary Medical Association.
  15. Layre, E., Lee, H.J., Young, D.C., Martinot, A.J., Buter, J., Minnaard, A.J., Annand, J.W., Fortune, S.M., Snider, B.B., Matsunaga, I., Rubin, E.J., Alber, T., Moody, D.B. 2014. Molecular profiling of Mycobacterium tuberculosis identifies tuberculosinyl nucleoside products of the virulence-associated enzyme Rv3378c. Proceedings of the National Academy of Sciences of the United States of America.
  16. Martinot, A.J., Meythaler, M., Pozzi, L.-A., Dalecki Boisvert, K., Knight, H., Walsh, D., Westmoreland, S., Anderson, D.C., Kaur, A., O'Neil, S.P. 2013. Acute SIV Infection in Sooty Mangabey Monkeys Is Characterized by Rapid Virus Clearance from Lymph Nodes and Absence of Productive Infection in Germinal Centers. PLoS ONE.
  17. Mishra, B.B., Rathinam, V.A.K., Martens, G.W., Martinot, A.J., Kornfeld, H., Fitzgerald, K.A., Sassetti, C.M. 2013. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β. Nature Immunology.
  18. Meythaler, M., Wang, Z., Martinot, A., Pryputniewicz, S., Kasheta, M., McClure, H.M., O'Neil, S.P., Kaur, A. 2011. Early induction of polyfunctional simian immunodeficiency virus (SIV)-specific T lymphocytes and rapid disappearance of SIV from lymph nodes of sooty mangabeys during primary infection. Journal of Immunology.
  19. Miller, A.D., Kramer, J.A., Lin, K.C., Knight, H., Martinot, A., Mansfield, K.G. 2010. Small intestinal adenocarcinoma in common marmosets (callithrix jacchus). Veterinary Pathology.
  20. Meythaler, M., Martinot, A., Wang, Z., Pryputniewicz, S., Kasheta, M., Ling, B., Marx, P.A., O'Neil, S., Kaur, A. 2009. Differential CD4+ T-lymphocyte apoptosis and bystander T-cell activation in rhesus macaques and sooty mangabeys during acute simian immunodeficiency virus infection. Journal of Virology.

General Research Interests

  • Mycobacterial genetics
  • Mycobacterial virulence factors
  • TB host-pathogen interaction
  • Development of novel TB vaccines
  • Murine and non-human primate models of human disease
  • Comparative pathology

Selected Research Projects

  • Development of Novel Whole Cell Vaccines for Tuberculosis

Research and Clinical Interests

  • Comparative pathology
  • Animal models for infectious disease research
  • Non-human primate pathology

Teaching

  • TB vaccine immunology
  • Animal Models of Human Diseases
  • Mentoring DVM students interested in careers in biomedical science
  • Mentoring women interested in STEM careers